Combination therapy with peptide epoxyketones
First Claim
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1. A method for treating cancer, comprising administering to a patient, in combination, (1) a peptide epoxyketone proteasome inhibitor, or a pharmaceutically acceptable salt thereof;
- and (2) a therapeutic agent;
wherein the peptide epoxyketone proteasome inhibitor has the following structure;
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Abstract
ABSTRACT The invention provides combination therapy, wherein one or more other therapeutic agents are administered agents are administered with peptide epoxyketones or a pharmaceutically acceptable salt thereof. Another aspect of the invention relates to treating cancer with a peptide epoxyketone administered in combination with another therapeutic agent.
126 Citations
17 Claims
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1. A method for treating cancer, comprising administering to a patient, in combination, (1) a peptide epoxyketone proteasome inhibitor, or a pharmaceutically acceptable salt thereof;
- and (2) a therapeutic agent;
wherein the peptide epoxyketone proteasome inhibitor has the following structure; - View Dependent Claims (2, 6, 8, 10, 11, 14, 15)
- and (2) a therapeutic agent;
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3. A method for treating cancer, consisting essentially of administering to a patient, in combination, (1) a peptide epoxyketone proteasome inhibitor, or a pharmaceutically acceptable salt thereof;
- (2) lenalidomide in an amount of at least 10 mg, and (3) dexamethasone;
wherein the peptide epoxyketone proteasome inhibitor has the following structure; - View Dependent Claims (4, 5, 7, 9, 12, 13, 16, 17)
- (2) lenalidomide in an amount of at least 10 mg, and (3) dexamethasone;
Specification