Anti-myostatin antibodies, polypeptides containing variant Fc regions, and methods of use

  • US 10,000,560 B2
  • Filed: 12/18/2015
  • Issued: 06/19/2018
  • Est. Priority Date: 12/19/2014
  • Status: Active Grant
First Claim
Patent Images

1. An isolated antibody that binds to latent myostatin, wherein the antibody comprises:

  • (a) a HVR-H1 comprising the amino acid sequence X1X2DIS (SEQ ID NO;

         126), wherein X1 is S or H, X2 is Y, T, D or E;

    (b) a HVR-H2 comprising the amino acid sequence IISX1AGX2X3YX4X5X6W AKX7 (SEQ ID NO;

         127), wherein X1 is Y or H, X2 is S or K, X3 is T, M or K, X4 is Y or K, X5 is A, M or E, X6 is S or E, X7 is G or K;

    (c) a HVR-H3 comprising the amino acid sequence GVPAX1SX2GGDX3 (SEQ ID NO;

         128), wherein X1 is Y or H, X2 is T or H, X3 is L or K;

    (d) a HVR-L1 comprising the amino acid sequence X1X2SQX3VX4X5X6NWLS (SEQ ID NO;

         129), wherein X1 is Q or T, X2 is S or T, X3 is S or E, X4 is Y or F, X5 is D or H, X6 is N, D, A or E;

    (e) a HVR-L2 comprising the amino acid sequence WAX1TLAX2 (SEQ ID NO;

         130), wherein X1 is S or E, X2 is S, Y, F or W (SEQ ID NO;

         130); and

    (f) a HVR-L3 comprising the amino acid sequence AGGYGGGX1YA (SEQ ID NO;

         131), wherein X1 is L or R.

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