System and method for generating a 2D image from a tomosynthesis data set

• US 10,010,302 B2
• Filed: 11/02/2017
• Issued: 07/03/2018
• Est. Priority Date: 11/27/2002
• Status: Active Grant

• Current Assignee: Hologic Incorporated
• Original Assignee: Hologic Incorporated
• Inventors: Ruth, Christopher, Smith, Andrew P., Stein, Jay
• Primary Examiner(s): Bayat, Ali
• Application Number:
  US15/802,225
• Publication Number:
  US 20180055470A1
• Time in Patent Office: 243 Days
• CPC Class Codes: A61B 6/025 Tomosynthesis
• CPC Class Codes: A61B 6/461 Displaying means of special interest
• CPC Class Codes: A61B 6/463 characterised by displaying multiple images or images and diagnostic data on one display
• CPC Class Codes: A61B 6/502 for diagnosis of breast, i.e. mammography
• CPC Class Codes: G06T 11/003 Reconstruction from projections, e.g. tomography
• CPC Class Codes: G06T 11/006 Inverse problem, transformation from projection-space into object-space, e.g. transform methods, back-projection, algebraic methods
• CPC Class Codes: G06T 11/008 Specific post-processing after tomographic reconstruction, e.g. voxelisation, metal artifact correction
• CPC Class Codes: G06T 11/60 Editing figures and text; Combining figures or text
• CPC Class Codes: G06T 19/00 Manipulating 3D models or images for computer graphics
• CPC Class Codes: G06T 19/20 Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts
• CPC Class Codes: G06T 2207/10081 Computed x-ray tomography [CT]
• CPC Class Codes: G06T 2207/10112 Digital tomosynthesis [DTS]
• CPC Class Codes: G06T 2207/20221 Image fusion; Image merging
• CPC Class Codes: G06T 2207/30068 Mammography; Breast
• CPC Class Codes: G06T 2207/30204 Marker
• CPC Class Codes: G06T 2210/41 Medical
• CPC Class Codes: G06T 2219/2008 Assembling, disassembling

Abstract

A 2D mammogram image is synthesized from at least one of tomosynthesis projection images and/or the tomosynthesis reconstructed image data. In a simplest form, the mammogram may be synthesized by selecting one of the tomosynthesis projection images for display as a synthesized mammogram. Other methods of synthesizing a mammogram include re-projecting and filtering projection data and/or reconstructed data. The synthesized mammogram is advantageously displayed together with at least a portion of the reconstructed data to aid in review of the reconstructed data. The present invention thus provides a familiar image which may be used to facilitate review of a tomosynthesis data set.

Claims

1. A system for evaluating breast tissue, comprising:

a processor configured to

process a plurality of tomosynthesis projection images of a patient'"'"'s breast tissue to generate a plurality of tomosynthesis reconstructed images;

generate a tomosynthesis data set comprising one or more of the plurality of tomosynthesis projection images and/or one or more of the plurality of tomosynthesis reconstructed images;

analyze the tomosynthesis data set using computer aided detection (CAD); and

generate a two-dimensional synthesized mammogram from the tomosynthesis data set, wherein the synthesized mammogram comprises a synthesized two-dimensional image that simulates a conventional mammography image.

2. The system of claim 1, wherein the two-dimensional synthesized mammogram is generated only from the plurality of tomosynthesis reconstructed images.

3. The system of claim 1, wherein the two-dimensional synthesized mammogram is generated only from the plurality of tomosynthesis projection images.

4. The system of claim 1, wherein the processor is configured to generate a CAD mark to be displayed on the synthesized mammogram by analyzing the tomosynthesis data.

5. The system of claim 1, further comprising a display device operatively coupled with the processor, wherein processor is configured to cause the synthesized mammogram on the display device.

6. The system of claim 5, wherein the processor is configured to generate a CAD mark by analyzing the tomosynthesis data set, and to cause the generated CAD mark to be displayed on the synthesized mammogram on the display device.

7. The system of claim 5, wherein the processor is configured to generate a CAD mark by analyzing the tomosynthesis data set, and to cause the generated CAD mark to be displayed on a tomosynthesis reconstructed image from the plurality of tomosynthesis reconstructed images on the display device.

8. The system of claim 5, wherein the processor is configured to generate a CAD mark by analyzing the tomosynthesis data set, and to cause the generated CAD mark to be displayed on a tomosynthesis projection image from the plurality of tomosynthesis projection images on the display device.

9. The system of claim 5, wherein the processor is configured to cause one of a tomosynthesis reconstructed image from the plurality of tomosynthesis reconstructed images and a tomosynthesis projection image from the plurality of tomosynthesis projection images to be displayed along with the synthesized mammogram on the display device.

10. The system of claim 5, wherein the display device is a radiologist workstation.

11. A system for generating and displaying a synthesized mammogram of a patient'"'"'s breast tissue, the system comprising a specially configured computer system, the computer system comprising

a reconstruction engine configured to receive a tomosynthesis data set comprising one or more of a plurality of tomosynthesis projection images and/or a plurality of tomosynthesis reconstructed slices, and

a synthesizer configured to generate a two-dimensional synthesized mammogram solely from the tomosynthesis data set using computer aided detection (CAD), wherein the synthesized mammogram comprises a synthesized two-dimensional image that simulates a conventional mammography image.

12. The system of claim 11, wherein the synthesizer is further configured to analyze the tomosynthesis data set using CAD to generate a CAD mark to be displayed on the synthesized mammogram.

13. A system for evaluating a patient'"'"'s breast tissue, comprising:

an image acquisition system configured to acquire tomosynthesis projection images of a patient'"'"'s breast; and

an image processing system operatively coupled with the image acquisition system, the image processing system configured to

generate an x-ray tomosynthesis data set of the patient'"'"'s breast, the x-ray tomosynthesis data set comprising one or more acquired tomosynthesis projection images and one or more tomosynthesis reconstructed images generated therefrom, and

synthesize a two-dimensional mammogram solely from the x-ray tomosynthesis data set, wherein the synthesized mammogram comprises a synthesized two-dimensional image that simulates a conventional mammography image.

14. The system of claim 13, wherein the image processing system is configured to perform filtering of at least one of the tomosynthesis projection images prior to synthesizing the two-dimensional mammogram.

15. The system of claim 13, further comprising a display device operatively coupled with the image processing system and configured to display the synthesized mammogram on the display device.

16. The system of claim 15, wherein the image processing system is further configured to process the x-ray tomosynthesis data set to obtain a CAD mark, and

cause the CAD mark to be displayed on the synthesized mammogram.

17. The system of claim 16, wherein the displayed CAD mark is overlaid on the synthesized mammogram.

18. The system of claim 15, wherein the image processing system is further configured to

reconstruct the tomosynthesis projection images into a three-dimensional reconstructed image comprising a plurality of image slices, and

cause the plurality of image slices to be sequentially or concurrently displayed with the synthesized mammogram on the display device.

19. The system of claim 18, wherein the image processing system is configured to reconstruct the tomosynthesis projection images onto a three-dimensional first coordinate system to provide an initial reconstruction.

20. The system of claim 13, wherein image processing system is configured to synthesize the two-dimensional mammogram by projecting at least one tomosynthesis slice image having a pixel spacing that differs from a pixel spacing of a mammogram onto a mammogram coordinate system.