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Solid pharmaceutical compositions containing pregabalin

DC
  • US 10,022,447 B2
  • Filed: 08/25/2017
  • Issued: 07/17/2018
  • Est. Priority Date: 11/02/2005
  • Status: Active Grant
First Claim
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1. A method of treating a condition or disorder in a subject which is responsive to pregabalin, the method comprising administering to the subject a pharmaceutical composition comprising an active pharmaceutical ingredient and excipients, the active pharmaceutical ingredient comprising pregabalin, or a pharmaceutically acceptable complex, salt, solvate or hydrate thereof, and the excipients comprising a matrix forming agent and a swelling agent, the matrix forming agent comprising polyvinyl acetate and polyvinylpyrrolidone, and the swelling agent comprising crosslinked polyvinylpyrrolidone, wherein the pharmaceutical composition is adapted for once-daily oral dosing;

  • wherein the pregabalin comprises from about 5% to about 60% of the pharmaceutical composition by weight;

    the matrix forming agent comprises from about 5% to about 45% of the pharmaceutical composition by weight, and the swelling agent comprises from about 15% to about 70% of the pharmaceutical composition by weight, wherein the composition is administered once daily.

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