Method and apparatus for sorting particles

  • US 10,029,263 B2
  • Filed: 03/22/2013
  • Issued: 07/24/2018
  • Est. Priority Date: 04/17/2002
  • Status: Active Grant
First Claim
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1. A microfluidic system for sorting particles, the microfluidic system comprising:

  • a first microfluidic flow channel formed in a particle processing component substrate having an upstream inlet configured to introduce a fluidic stream having a plurality of particles into the first microfluidic flow channel and downstream outlets configured to output portions of the fluidic stream of particles;

    a detection region located downstream of the inlet, the detection region configured to allow a particle having a predetermined characteristic to be sensed, the sensed particle being one of the plurality of particles in the fluidic stream; and

    a switching device located downstream of the detection region, the switching device operatively coupled to the first microfluidic flow channel to deliver a transient pressure pulse in a direction substantially perpendicular to a flow direction of the fluidic stream of particles,wherein the transient pressure pulse displaces and separates a selected single sensed particle from the fluidic stream of particles,wherein the selected particle is displaced and separated from the fluidic stream of particles in a switching region,wherein the fluidic stream of unselected particles flows into a first downstream outlet configured to output a first portion of the fluidic stream of particles,wherein the selected particle flows into a second downstream outlet configured to output a second portion of the fluidic stream of particles,wherein the transient pressure pulse is not generated downstream of the switching region,wherein the switching device, when activated, does not block or partially block flow of the fluidic stream of particles, andwherein the particle processing component substrate includes a reservoir adapted for dampening or absorbing the transient pressure pulse propagated across the microfluidic channel.

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