Electrophysiological signal processing and utilization

• US 10,039,502 B2
• Filed: 04/12/2011
• Issued: 08/07/2018
• Est. Priority Date: 04/12/2011
• Status: Active Grant

• Current Assignee: Medtronic Ablation Frontiers LLC (Medtronic Plc)
• Original Assignee: Medtronic Ablation Frontiers LLC (Medtronic Plc)
• Inventors: Stewart, Mark T., Davie, Scott W., Desrochers, Giles
• Primary Examiner(s): D ABREU, MICHAEL JOSEPH
• Application Number:
  US13/084,853
• Publication Number:
  US 20120265084A1
• Time in Patent Office: 2,674 Days
• Field of Search: 600424, 600523
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/33 specially adapted for cooperation with other devices
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 5/743 Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 6/503 for diagnosis of the heart
• CPC Class Codes: A61B 8/0841 for locating instruments
• CPC Class Codes: A61B 8/0883 for diagnosis of the heart

Abstract

A method of mapping electrophysiological information, including receiving imaging information for a tissue region; receiving a monophasic action potential signal from the tissue region; assigning a value corresponding to a depolarization segment of the monophasic action potential signal; receiving location information associated with the monophasic action potential signal; and generating an image based on the imaging information, the assigned value, and the location information.

Claims

1. A method of displaying electrophysiological information;

comprising;

obtaining a three-dimensional rendering of an anatomical region;

obtaining a monophasic action potential signal with a medical device from at least a portion of the anatomical region;

obtaining an electrocardiogram signal from at least a portion of the anatomical region;

calculating a value associated with a depolarization segment of the monophasic action potential signal;

displaying a graphical indicator of the value on the rendering of the anatomical region;

comparing at least a portion of the monophasic action potential signal to at least a portion of the electrocardiogram signal and assessing the contact between the medical device and the anatomical region based at least in part on the comparison; and

generating an alert based at least in part on the comparison.

2. The method of claim 1, wherein the three-dimensional rendering is generated using electric potential-based navigation.

3. The method of claim 1, wherein the electric potential-based navigation includes tracking one or more electrodes in three-dimensional space in proximity to the anatomical region.

4. The method of claim 1, wherein calculating the value associated with the depolarization segment includes calculating a time duration.

5. The method of claim 1, wherein calculating the value associated with the depolarization segment includes calculating an upstroke velocity.

6. The method of claim 1, wherein calculating the value associated with the depolarization segment includes:

calculating a maximum amplitude value; and

calculating a time duration for the monophasic action potential signal to recede to a predetermined percentage of the maximum amplitude value.

7. The method of claim 1, further comprising identifying a tissue structure based at least in part on the calculated value.

8. The method of claim 1, wherein obtaining the monophasic action potential signal includes contacting the anatomical region with a medical device, and the generating an alert comprises generating a contact status indication.

9. The method of claim 1, wherein comparing at least a portion of the monophasic action potential signal to the electrocardiogram signal includes comparing a portion of the monophasic action potential signal to a T-wave portion of the electrocardiogram signal.

10. The method of claim 1, wherein the graphical indicator includes a color assigned to the value.

11. The method of claim 1, wherein the anatomical region includes at least a portion of a heart.

12. The method of claim 1, further comprising generating a graphical treatment indicator on the rendering based at least in part on the calculated value, the graphical treatment indicator providing a recommended treatment location.

13. A method of mapping electrophysiological information, comprising:

receiving imaging information for a tissue region;

receiving a monophasic action potential signal from the tissue region using a medical device with one or more mapping electrodes;

receiving an electrocardiogram signal from the tissue region using the medical device;

assigning a value corresponding to a depolarization segment of the monophasic action potential signal;

receiving location information associated with the monophasic action potential signal;

generating an image based on the imaging information, the assigned value, and the location information; and

comparing at least a portion of the monophasic action potential signal and at least a portion of the electrocardiogram signal and assessing the quality of the monophasic action potential signal based at least in part on the comparison.

14. The method of claim 13, wherein receiving a monophasic action potential signal from the tissue region includes obtaining a monophasic action potential signal with a medical device proximate to the tissue region.

15. The method of claim 14, wherein receiving location information associated with the monophasic action potential signal includes obtaining location information of the medical device.

16. The method of claim 13, wherein generating an image includes displaying a three-dimensional rendering of the tissue region.

17. The method of claim 16, wherein the rendering includes a color variation indicating the assigned value at a location on the rendering corresponding to the received location information.

18. The method of claim 13, wherein receiving imaging information for a tissue region includes receiving three-dimensional electric potential information.

19. The method of claim 13, wherein the rendering includes a color variation indicating a suggested location for treatment.

20. A medical system, comprising:

a display;

a control unit in communication with the display, the control unit programmed to;

receive a monophasic action potential signal,

receive three-dimensional location information associated with the monophasic action potential signal,

receive an electrocardiogram signal;

calculate a value corresponding to a depolarization segment of the monophasic action potential signal;

generate an image based on the three-dimensional location information and the calculated value; and

compare at least one of a timing and a waveform of the monophasic action potential signal to at least one of a P-wave segment, a QRS complex, and a T-wave segment of the electrocardiogram signal and assess the quality of the monophasic action potential signal based at least in part on the comparison.

21. The system of claim 20, wherein the control unit is programmed to:

generate an alert based at least in part on the comparison between the at least a portion of the monophasic action potential signal and the at least a portion of the electrocardiogram signal.

22. The system of claim 20, further comprising a medical device in communication with the control unit, the medical device including a plurality of electrodes.

23. The system of claim 20, further comprising an image acquisition device in communication with the control unit.