Controlled electrochemical activation of carbon-based electrodes

• US 10,041,900 B2
• Filed: 02/27/2015
• Issued: 08/07/2018
• Est. Priority Date: 11/23/2009
• Status: Active Grant

• Current Assignee: Proxim Diagnostics, Proxim Diagnostics Corporation
• Original Assignee: Proxim Diagnostics Corporation
• Inventors: Briman, Mikhail
• Primary Examiner(s): NOGUEROLA, ALEXANDER STEPHAN
• Application Number:
  US14/633,145
• Publication Number:
  US 20150168331A1
• Time in Patent Office: 1,257 Days
• CPC Class Codes: G01N 27/26 by investigating electrochemical variables; by using electrolysis or electrophoresis
• CPC Class Codes: G01N 27/30 Electrodes, e.g. test electrodes; Half-cells G01N27/414 takes precedence
• CPC Class Codes: G01N 27/327 Biochemical electrodes , e.g. electrical or mechanical details for in vitro measurements
• CPC Class Codes: G01N 27/3276 being a hybridisation with immobilised receptors using a FET type sensor G01N27/4145; concerning the hybridisation C12Q1/68
• CPC Class Codes: G01N 27/38 Cleaning of electrodes

Abstract

Certain embodiments of the present application describe a process to perform activation of carbon based electrodes in a controlled manner, where the degree of activation is monitored and calculated simultaneously with the ongoing activation process. Such an approach is intended to improve the reproducibility of electrodes that may include, but are not limited to, the following parameters: electrochemical capacitance, electrochemical transfer coefficient, amperiometric response to enzymatic reactions.

Claims

1. An electrochemical sensor, comprising:

a reference electrode;

a first screen-printed carbon-based sensor electrode having a first electrochemical capacitance with respect to the reference electrode; and

a second screen-printed carbon-based sensor electrode having a second electrochemical capacitance with respect to the reference electrode;

wherein the first electrochemical capacitance and the second electrochemical capacitance have a CV % between 0.4% and 1%.

2. The electrochemical sensor of claim 1, wherein the first electrochemical capacitance and the second electrochemical capacitance have a value between 4 uF/cm^2 and 10 uF/cm^2.

3. The electrochemical sensor of claim 1, wherein the first screen-printed carbon-based sensor electrode and the second screen-printed carbon-based sensor electrode were both controllably activated.

4. The electrochemical sensor of claim 3, wherein the first screen-printed carbon-based sensor electrode and the second screen-printed carbon-based sensor electrode were both controllably activated by exposing the first screen-printed carbon-based sensor electrode and the second screen-printed carbon-based sensor electrode to an aqueous solution and cyclically applying a first electric potential to the first carbon-based sensor electrode and a second electric potential to the second carbon-based sensor electrode versus the reference electrode.