Ex vivo organ care system
First Claim
Patent Images
1. A perfusion circuit for perfusing a liver ex-vivo comprising:
- A pump for providing pulsatile fluid flow of a perfusion fluid through the circuit;
a gas exchanger;
a divider in fluid communication with the pump configured to divide the perfusion fluid flow into a first branch and a second branch;
wherein the first branch comprises a hepatic artery interface;
wherein the first branch is configured to provide a first portion of the perfusion fluid to a hepatic artery of the liver at a high pressure between 25-150 mmHg and low flow rate between 0.25-1 L/min via the hepatic artery interface;
wherein the first branch is in fluid pressure communication with the pump;
wherein the second branch comprises a portal vein interface;
wherein the second branch is configured to provide a second portion of the perfusion fluid to a portal vein of the liver at a low pressure between 1-25 mmHg and high flow rate between 0.75 to 2 L/min via the portal vein interface;
the second branch further comprising a clamp located between the divider and the portal vein interface for selectively controlling the flow rate of perfusion fluid to the portal vein;
the second branch further comprising a compliance chamber configured to reduce the pulsatile flow characteristics of the perfusion fluid from the pump to the portal vein;
wherein the pump is configured to provide a pulsatile flow of perfusion fluid through the first branch including the hepatic artery interface to provide the first portion of the perfusion fluid to the hepatic artery of the liver at the high pressure between 25-150 mmHg and low flow rate between 0.25-1 L/min and the second branch including the portal vein interface to provide a second portion of the perfusion fluid to the portal vein of the liver at the low pressure between 1-25 mmHg and high flow rate between 0.75 to 2 L/min;
a drain configured to receive perfusion fluid from an inferior vena cava of the liver; and
a reservoir positioned below the liver and located between drain and the pump, configured to receive the perfusion fluid from the drain and store a volume of fluid.
3 Assignments
0 Petitions
Accused Products
Abstract
The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.
249 Citations
20 Claims
-
1. A perfusion circuit for perfusing a liver ex-vivo comprising:
-
A pump for providing pulsatile fluid flow of a perfusion fluid through the circuit; a gas exchanger; a divider in fluid communication with the pump configured to divide the perfusion fluid flow into a first branch and a second branch; wherein the first branch comprises a hepatic artery interface; wherein the first branch is configured to provide a first portion of the perfusion fluid to a hepatic artery of the liver at a high pressure between 25-150 mmHg and low flow rate between 0.25-1 L/min via the hepatic artery interface; wherein the first branch is in fluid pressure communication with the pump; wherein the second branch comprises a portal vein interface; wherein the second branch is configured to provide a second portion of the perfusion fluid to a portal vein of the liver at a low pressure between 1-25 mmHg and high flow rate between 0.75 to 2 L/min via the portal vein interface; the second branch further comprising a clamp located between the divider and the portal vein interface for selectively controlling the flow rate of perfusion fluid to the portal vein; the second branch further comprising a compliance chamber configured to reduce the pulsatile flow characteristics of the perfusion fluid from the pump to the portal vein; wherein the pump is configured to provide a pulsatile flow of perfusion fluid through the first branch including the hepatic artery interface to provide the first portion of the perfusion fluid to the hepatic artery of the liver at the high pressure between 25-150 mmHg and low flow rate between 0.25-1 L/min and the second branch including the portal vein interface to provide a second portion of the perfusion fluid to the portal vein of the liver at the low pressure between 1-25 mmHg and high flow rate between 0.75 to 2 L/min; a drain configured to receive perfusion fluid from an inferior vena cava of the liver; and a reservoir positioned below the liver and located between drain and the pump, configured to receive the perfusion fluid from the drain and store a volume of fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7)
-
-
8. A system for perfusing an ex vivo liver at near physiologic conditions comprising:
a perfusion circuit comprising; a pump for pumping a pulsatile perfusion fluid flow through the circuit; a divider in fluid communication with the pump configured to divide the perfusion fluid into a hepatic artery interface and a portal vein interface; wherein the pump provides perfusion fluid to a hepatic artery of the liver at a high pressure between 25-150 mmHg and low flow rate between 0.25-1 L/min via the divider and the hepatic artery interface; and wherein the pump provides perfusion fluid to the portal vein of the liver at a low pressure between 1-25 mmHg and high flow rate between 0.75 to 2 L/min via the divider and the portal vein interface; a gas exchanger; a heating subsystem for maintaining the temperature of the perfusion fluid at a normothermic temperature; a drain configured to receive the perfusion fluid from an inferior vena cava of the liver; a reservoir configured to receive perfusion fluid from the drain and store a volume of fluid. - View Dependent Claims (9, 10, 11, 12)
-
13. A system for preserving a liver ex vivo at physiologic conditions comprising:
-
a multiple use module comprising a pulsatile pump; a single use module comprising; a perfusion circuit configured to provide pulsatile perfusion fluid flow to the liver; a pump interface assembly for translating pulsatile pumping from the pump to the perfusion fluid; a hepatic artery interface configured to deliver perfusion fluid to a hepatic artery of the liver; a portal vein interface configured to deliver perfusion fluid to a portal vein of the liver; a divider to supply the pulsatile perfusion fluid flow from the pump interface assembly to the hepatic artery interface at a high pressure between 25-150 mmHg and low flow rate between 0.25-1 L/min and to the portal vein interface at a low pressure between 1-25 mmHg and high flow rate between 0.75 to 2 L/min; an organ chamber assembly configured to hold an ex vivo organ, the organ chamber assembly including a housing; a flexible support surface suspended within the organ chamber assembly; and a bile container configured to collect bile produced by the liver. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
-
Specification