System and method for nested neurostimulation
First Claim
1. A method to deliver nested stimulation to nerve tissue of interest, the method comprising:
- setting first parameters that define a carrier waveform;
setting second parameters that define a high frequency waveform, wherein at least one of the carrier waveform and high frequency waveform are defined to correspond to physiologic neural oscillations associated with the nerve tissue of interest;
operating a pulse generator to generate a nested stimulation waveform that combines the carrier waveform and high frequency waveform, the nested stimulation waveform having a plurality of pulse bursts, wherein (1) each of the pulse bursts comprise a plurality of discrete pulses, (2) pulses within each pulse burst are repeated according to a frequency parameter of the high frequency waveform, and (3) an amplitude of each discrete pulse within respective pulse bursts is controlled according to nesting of the high frequency waveform with the carrier waveform such that amplitude peaks of the corresponding plurality of discrete pulses vary within each respective pulse burst; and
delivering the nested stimulation waveform through one or more electrodes to the nerve tissue of interest;
measuring intrinsic neural oscillations, determining whether the nested stimulation waveform is achieving entrainment of the intrinsic neural oscillations, and adjusting at least one of the first and second parameters to maintain entrainment of the intrinsic neural oscillations.
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Abstract
A method and system are provided to deliver nested stimulation to brain tissue of interest. The method and system set first parameters that define a carrier waveform. The method and system set second parameters that define a high frequency waveform, wherein at least one of the carrier waveform and high frequency waveform are defined to correspond to physiologic neural oscillations associated with the brain tissue of interest. The method and system operates a pulse generator to generate a nested stimulation waveform that combines the carrier waveform and high frequency waveform. The nested stimulation waveform has a plurality of pulse bursts. The method and system deliver the nested stimulation waveform through one or more electrodes to the brain tissue of interest.
11 Citations
13 Claims
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1. A method to deliver nested stimulation to nerve tissue of interest, the method comprising:
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setting first parameters that define a carrier waveform; setting second parameters that define a high frequency waveform, wherein at least one of the carrier waveform and high frequency waveform are defined to correspond to physiologic neural oscillations associated with the nerve tissue of interest; operating a pulse generator to generate a nested stimulation waveform that combines the carrier waveform and high frequency waveform, the nested stimulation waveform having a plurality of pulse bursts, wherein (1) each of the pulse bursts comprise a plurality of discrete pulses, (2) pulses within each pulse burst are repeated according to a frequency parameter of the high frequency waveform, and (3) an amplitude of each discrete pulse within respective pulse bursts is controlled according to nesting of the high frequency waveform with the carrier waveform such that amplitude peaks of the corresponding plurality of discrete pulses vary within each respective pulse burst; and delivering the nested stimulation waveform through one or more electrodes to the nerve tissue of interest; measuring intrinsic neural oscillations, determining whether the nested stimulation waveform is achieving entrainment of the intrinsic neural oscillations, and adjusting at least one of the first and second parameters to maintain entrainment of the intrinsic neural oscillations. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A system to deliver nested stimulation to nerve tissue of interest, the system comprising:
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a lead having a plurality of stimulation electrodes and sensing electrodes, the lead configured to be implanted at a target position proximate to nerve tissue of interest; and an implantable medical device (IMD) coupled to the lead, the IMD including a processor and memory storing programmable instructions, the processor executing the programmable instructions to; set first parameters that define a carrier waveform; set second parameters that define a high frequency waveform, wherein at least one of the carrier waveform and high frequency waveform are defined to correspond to physiologic neural oscillations associated with the nerve tissue of interest; operate a pulse generator to generate a nested stimulation waveform that combines the carrier waveform and high frequency waveform, the nested stimulation waveform having a plurality of pulse bursts, wherein (1) each of the pulse bursts comprise a plurality of discrete pulses, (2) pulses within each pulse burst are repeated according to a frequency parameter of the high frequency waveform, and (3) an amplitude of each discrete pulse within respective pulse bursts is controlled according to nesting of the high frequency waveform with the carrier waveform such that amplitude peaks of the corresponding plurality of discrete pulses vary within each respective pulse burst; and deliver the nested stimulation waveform through one or more electrodes to the nerve tissue of interest; measure intrinsic neural oscillations through the sensing electrodes, determine whether the nested stimulation waveform is achieving entrainment of the intrinsic neural oscillations; and
adjust at least one of the first and second parameters to maintain entrainment of the intrinsic neural oscillations. - View Dependent Claims (10, 11, 12, 13)
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Specification