High data rate integrated circuit with power management

• US 10,077,472 B2
• Filed: 12/10/2015
• Issued: 09/18/2018
• Est. Priority Date: 12/18/2014
• Status: Active Grant

• Current Assignee: Life Technologies Corporation (Thermo Fisher Scientific Incorporated)
• Original Assignee: Life Technologies Corporation (Thermo Fisher Scientific Incorporated)
• Inventors: Fife, Keith G., Yang, Jungwook
• Primary Examiner(s): Sines, Brian J
• Application Number:
  US14/965,568
• Publication Number:
  US 20160177385A1
• Time in Patent Office: 1,013 Days
• Field of Search: 422 681, 422 81, 422502, 422503, 436 43, 436 89, 436 94, 436 63, 436149, 436150, 436151
• CPC Class Codes: C12Q 1/6874 involving nucleic acid arrays, e.g. sequencing by hybridisation
• CPC Class Codes: G01N 2035/00881 network configurations
• CPC Class Codes: G01N 27/4145 specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
• CPC Class Codes: G01N 27/4148 Integrated circuits therefor, e.g. fabricated by CMOS processing CMOS processing per se H01L21/82
• CPC Class Codes: G01N 35/00712 Automatic status testing, e.g. at start-up or periodic
• CPC Class Codes: G01N 35/00871 Communications between instruments or with remote terminals

Abstract

A sensor device includes a sensor array and a flow cell in fluid communication with the sensor array. Bias circuitry apply bias arrangements to the sensor array to produce sensor data. Peripheral circuitry coupled to the bias circuitry produces streams of data from the sensor array, the peripheral circuitry having an active mode and an idle mode. Logic to switch the peripheral circuitry between the active mode and the idle mode to control power consumption is provided. A temperature sensor may be included, and the logic can operate with feedback to switch between the active mode and the idle mode to maintain the temperature within an operating range.

Claims

1. A sensor device, comprising:

a data source including an analog sensor array on a substrate;

peripheral circuitry coupled to the sensor array configured to produce a plurality of streams of digital data;

a plurality of transmitters on the substrate configured to receive corresponding streams of data from the data source in parallel;

a temperature sensor configured to sense a temperature that correlates with the temperature of the sensor array;

a sequencer configured to operate the data source, the peripheral circuitry and the plurality of transmitters to sample frames of data at a frame rate according an active mode and an idle mode, wherein the sequencer operates in the active mode for a first number of frames in a time interval overlapping with a flow of reactant solution and in the idle mode for a second number of frames in a time interval overlapping with an immediately following flow of wash solution; and

a controller coupled with the temperature sensor and the sequencer configured to adjust the first and second number of frames in response to the sensed temperature.

2. The sensor device of claim 1, wherein the analog sensor array comprises an array of chemically sensitive field effect transistors.

3. The sensor device of claim 1, wherein the plurality of transmitters includes at least 20 transmitters for transmitting at a data rate greater than 1 Gb per second, and is configured in at least 10 pairs.

4. The sensor device of claim 1, wherein the sequencer maintains transmission of data using the plurality of transmitters during the idle mode.

5. The sensor device of claim 1, wherein the sequencer includes logic to set operating power parameters for a circuit or circuits in the peripheral circuitry for sensing data in the active mode, and for lower power consumption during the idle mode.

6. The sensor device of claim 1, wherein the peripheral circuitry includes an analog-to-digital ADC converter, and the sequencer includes logic to set a first effective number of bits parameter for the analog-to-digital converter in the active mode, and a second effective number of bits parameter, lower than the first, for the analog-to-digital converter in the idle mode.

7. The sensor device of claim 1, wherein the peripheral circuitry includes a digital-to-analog DAC converter to produce a reference ramp signal, and the sequencer includes logic to set a DAC parking address parameter for the digital-to-analog converter in the idle mode.

8. The sensor device of claim 1, wherein the peripheral circuitry includes a gray code counter to produce a digital count value, and the sequencer includes logic to set a gray code counter parking address parameter in the idle mode.

9. The sensor device of claim 1, wherein the peripheral circuitry includes a comparator, and the sequencer includes logic to set a first comparator power level parameter in the active mode, and a second comparator power level parameter, lower than the first, in the idle mode.

10. The sensor device of claim 1, wherein the peripheral circuitry includes a latch for each column of the array, and the sequencer includes logic to set a latch state in the idle mode.