Topical tetracycline compositions

  • US 10,086,080 B2
  • Filed: 03/06/2018
  • Issued: 10/02/2018
  • Est. Priority Date: 10/02/2009
  • Status: Active Grant
First Claim
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1. A method of treating acne vulgaris, comprising administeringa waterless foam composition comprisinga minocycline and a foamable carrier, the carrier comprising:

  • a) at least one hydrophobic oil; and

    b) an agent comprising (i) at least one fatty alcohol and at least one wax;

    (ii) at least one fatty acid and at least one wax;

    (iii) at least one fatty alcohol, at least one fatty acid, and at least one wax;

    (iv) a wax comprising a hydrogenated oil;

    or (v) a combination of two or more waxes;

    wherein the composition does not contain one or more minocycline incompatible substance selected from the group consisting of dimethyl sulfoxide (DMSO), dimethylformamide (DMF), acetonitrile, acetone, methyl ethyl ketone, 1,4-dioxane, tetrahydrofuran (THF), N-methylpyrrolidone, pyridine, piperidine, N-methyl-2-pyrrolidone and 1-methyl-2-pyrrolidinone), azone (1-dodecylazacycloheptan-2-one), dimethyl isosorbide, glycerin, ethanol, propylene glycol, butylene glycol, PEG 200, hexylene glycol, PEG 400, diethylene glycol monoethyl ether, pomegranate seed oil, isostearic acid, and ethocel;

    wherein the composition does not contain a surfactant;

    and wherein the composition does not contain a polyol.

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