Methods and devices for inhibiting nerves when activating brown adipose tissue

• US 10,092,738 B2
• Filed: 12/29/2014
• Issued: 10/09/2018
• Est. Priority Date: 12/29/2014
• Status: Active Grant

• Current Assignee: Cilag Gmbh International (Johnson & Johnson)
• Original Assignee: Ethicon, LLC (Johnson & Johnson)
• Inventors: Harris, Jason L., Baynham, Tamara C.
• Primary Examiner(s): GRAY, PHILLIP A
• Application Number:
  US14/584,046
• Publication Number:
  US 20160184568A1
• Time in Patent Office: 1,380 Days
• Field of Search: 604 20
• CPC Class Codes: A61F 7/00 Heating or cooling appliances for medical or therapeutic treatment of the human body heating or cooling means in connection with bedsteads or mattresses A47C21/00 ; massage, therapeutic baths A61H; hyperthermia using electric or magnetic fields or ultrasound A61N; electric heating elements H05B
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61N 1/0456 Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/0492 Patch electrodes A61N1/0412, A61N1/0428 take precedence
• CPC Class Codes: A61N 1/36034 specified by the stimulation parameters
• CPC Class Codes: A61N 1/36171 Frequency
• CPC Class Codes: A61N 5/0622 Optical stimulation for exciting neural tissue

Abstract

Methods and devices are provided for inhibiting nerves when activating brown adipose tissue (BAT). In general, a first nerve type (e.g., sympathetic nerves) innervating BAT can be activated while at least one other nerve type (e.g., parasympathetic nerves and/or sensory nerves) innervating BAT is being suppressed. A first neuromodulator (e.g., an electrical signal, a chemical, a light, cooling, etc.) can be applied to activate the first nerve type, and a second neuromodulator can be applied to inhibit the at least one other nerve type. In this way, parasympathetic nerves and/or sensory nerves innervating BAT can be inhibited when activating sympathetic nerves innervating BAT.

Claims

1. A medical method, comprising:

applying a first neuromodulator to a depot of brown adipose tissue (BAT), the application of the first neuromodulator causing activation of a first nerve type in the BAT so as to increase energy expenditure of the BAT, wherein applying the first neuromodulator comprises at least one of applying an electrical signal to the depot of BAT, delivering a chemical to the depot of BAT, cooling the depot of BAT, and applying a light to the depot of BAT; and

applying a second neuromodulator to the depot of BAT simultaneously with the application of the first neuromodulator, the application of the second neuromodulator inhibiting a second nerve type in the BAT that is different from the first nerve type, wherein applying the second neuromodulator comprises at least one of applying a different electrical signal to the depot of BAT, delivering a different chemical to the depot of BAT, cooling the depot of BAT, and applying a different light to the depot of BAT;

wherein the application of the second neuromodulator starts before the application of the first neuromodulator begins so as to start inhibiting the second nerve type before the first nerve type is activated; and

wherein the application of the first neuromodulator is configured to cause activation of the second nerve type, and the application of the second neuromodulator starts before the application of the first neuromodulator begins so as to prevent the second nerve type from being activated by the application of the first neuromodulator.

2. The method of claim 1, wherein the first nerve type includes sympathetic nerves, and the second nerve type includes parasympathetic nerves.

3. The method of claim 1, wherein the first nerve type includes sympathetic nerves, and the second nerve type includes sensory nerves.

4. The method of claim 1, wherein applying the first neuromodulator comprises applying a first electrical signal to the depot of BAT, and applying the second neuromodulator comprises applying a second electrical signal to the depot of BAT that is different from the first electrical signal.

5. The method of claim 1, wherein applying one of the first and second neuromodulators comprises applying an electrical signal to the depot of BAT, and applying the other of the first and second neuromodulators comprises delivering a chemical to the depot of BAT.

6. The method of claim 1, wherein applying the first neuromodulator comprises delivering a first chemical to the depot of BAT, and applying the second neuromodulator comprises delivering a second chemical to the depot of BAT that is different from the first chemical.

11. The method of claim 4, further comprising selecting the first and second electrical signals based on a diameter of nerve fibers of the first nerve type and a diameter of nerve fibers of the second nerve type.

12. The method of claim 4, wherein the second electrical signal has less energy than the first electrical signal.

13. The method of claim 12, wherein the second electrical signal has less energy than the first electrical signal by having less current than the first electrical signal, by including a hyperpolarizing lower energy pulse as compared to the first electrical signal, or by including a depolarizing lower energy pulse as compared to the first electrical signal.

7. A medical method, comprising:

neuromodulating a sympathetic nervous system of a patient proximate to a depot of brown adipose tissue (BAT) of a patient so as to activate the BAT and increase energy expenditure of the BAT, wherein neuromodulating the sympathetic nervous system comprises applying a first electrical signal to the patient; and

simultaneously with the neuromodulating of the sympathetic nervous system, suppressing a parasympathetic nervous system of the patient proximate to the depot of brown adipose tissue, wherein suppressing the parasympathetic nervous system comprises applying a second electrical signal to the patient, the second electrical signal having less energy than the first electrical signal by as compared to the first electrical signal, or by including a depolarizing lower energy pulse as compared to the first electrical signal.

8. The method of claim 7, wherein neuromodulating the sympathetic nervous system activates sympathetic nerves innervating the BAT, and suppressing the parasympathetic nervous system suppresses parasympathetic nerves innervating the BAT, each of the parasympathetic nerves having a larger diameter than each of the sympathetic nerves.

9. The method of claim 7, wherein the suppression of the parasympathetic nervous system begins before the neuromodulation of the sympathetic nervous system so as to start suppressing the parasympathetic nervous system before the sympathetic nervous system is neuromodulated.

10. The method of claim 7, wherein the second electrical signal has less energy than the first electrical signal by having less current than the first electrical signal, and a current of the first electrical signal is in a range of ten to one hundred times greater than a current of the second electrical signal.

14. A medical method, comprising:

neuromodulating a sympathetic nervous system of a patient proximate to a depot of brown adipose tissue (BAT) of a patient by delivering a first stimulation to the BAT so as to activate the BAT and increase energy expenditure of the BAT; and

simultaneously with the neuromodulating of the sympathetic nervous system, suppressing a parasympathetic nervous system of the patient proximate to the depot of brown adipose tissue by delivering a second stimulation to the BAT;

wherein the delivery of the second stimulation starts before the delivery of the first stimulation such that suppression of the parasympathetic nervous system starts before the neuromodulation of the sympathetic nervous system, and

wherein the delivery of the first stimulation is configured to cause activation of the parasympathetic nervous system, and the delivery of the second stimulation starts before the delivery of the first stimulation so as to prevent the parasympathetic nervous system from being activated by the delivery of the first stimulation.

15. The method of claim 14, wherein neuromodulating the sympathetic nervous system activates sympathetic nerves innervating the BAT, and suppressing the parasympathetic nervous system suppresses parasympathetic nerves innervating the BAT, each of the parasympathetic nerves having a larger diameter than each of the sympathetic nerves.

16. The method of claim 14, wherein neuromodulating the sympathetic nervous system comprises delivering a first electrical signal to the patient, and suppressing the parasympathetic nervous system comprises delivering a second electrical signal to the patient that is different than the first electrical signal.

17. The method of claim 16, wherein a current of the first electrical signal is in a range of ten to one hundred times greater than a current of the second electrical signal.

18. The method of claim 16, wherein the second electrical signal comprises one of a hyperpolarizing lower energy pulse as compared to the first electrical signal, and a depolarizing lower energy pulse as compared to the first electrical signal.

19. The method of claim 14, wherein neuromodulating the sympathetic nervous system comprises delivering a first electrical signal to the patient, and suppressing the parasympathetic nervous system comprises delivering a chemical to the patient.

20. The method of claim 14, wherein neuromodulating the sympathetic nervous system comprises delivering a first chemical to the patient, and suppressing the parasympathetic nervous system comprises one of delivering a second chemical to the patient that is different than the first chemical and delivering an electrical signal to the patient.

21. The method of claim 14, wherein neuromodulating the sympathetic nervous system comprises at least one of delivering an electrical signal to the patient, delivering a chemical to the patient, cooling the patient, and delivering a light to the patient.