Porous microneedles through sacrificial sugar incorporation, analyte detection system, and method for intradermal optode nanosensor implantation
First Claim
1. A system comprising:
- (a) a skin-mountable device, comprising;
a plurality of micro-needles, each having a base end and a tip, wherein the micro-needles comprise a sacrificial agent, wherein the sacrificial agent is configured to dissolve in interstitial fluid to form channels in the micro-needles;
a substrate attached to the base ends of the micro-needles, wherein the substrate is configured for attachment to an external skin surface such that the micro-needles penetrate into the skin to contact interstitial fluid; and
nanosensors encapsulated in the micro-needles, the nanosensors comprising nanoparticles having a detectable label and configured to interact with a target analyte present in interstitial fluid; and
(b) a reader device, wherein the reader device is configured to detect the target analyte via interaction with the skin-mountable device.
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0 Petitions
Accused Products
Abstract
A device and system for measuring and/or monitoring an analyte present on the skin is provided. The system includes a skin-mountable device that may be attached to an external skin surface and a reader device. The skin-mountable device includes a substrate, a plurality of micro-needles, and nanosensors encapsulated in the micro-needles. The micro-needles are attached to the substrate such that attachment of the substrate to an external skin surface causes to the micro-needles to penetrate into the skin to contact interstitial fluid. The micro-needles can include a sacrificial agent and are configured to become porous on contact with a solvent, e.g., interstitial fluid, which dissolves at least a portion of the sacrificial agent. The nanosensors encapsulated in the micro-needles include a detectable label and are configured to interact with a target analyte present in the interstitial fluid. The reader device is configured to detect the analyte in interstitial fluid via interaction with the skin-mountable device.
36 Citations
12 Claims
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1. A system comprising:
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(a) a skin-mountable device, comprising; a plurality of micro-needles, each having a base end and a tip, wherein the micro-needles comprise a sacrificial agent, wherein the sacrificial agent is configured to dissolve in interstitial fluid to form channels in the micro-needles; a substrate attached to the base ends of the micro-needles, wherein the substrate is configured for attachment to an external skin surface such that the micro-needles penetrate into the skin to contact interstitial fluid; and nanosensors encapsulated in the micro-needles, the nanosensors comprising nanoparticles having a detectable label and configured to interact with a target analyte present in interstitial fluid; and (b) a reader device, wherein the reader device is configured to detect the target analyte via interaction with the skin-mountable device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification