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Porous microneedles through sacrificial sugar incorporation, analyte detection system, and method for intradermal optode nanosensor implantation

  • US 10,098,574 B1
  • Filed: 07/07/2015
  • Issued: 10/16/2018
  • Est. Priority Date: 07/07/2015
  • Status: Active Grant
First Claim
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1. A system comprising:

  • (a) a skin-mountable device, comprising;

    a plurality of micro-needles, each having a base end and a tip, wherein the micro-needles comprise a sacrificial agent, wherein the sacrificial agent is configured to dissolve in interstitial fluid to form channels in the micro-needles;

    a substrate attached to the base ends of the micro-needles, wherein the substrate is configured for attachment to an external skin surface such that the micro-needles penetrate into the skin to contact interstitial fluid; and

    nanosensors encapsulated in the micro-needles, the nanosensors comprising nanoparticles having a detectable label and configured to interact with a target analyte present in interstitial fluid; and

    (b) a reader device, wherein the reader device is configured to detect the target analyte via interaction with the skin-mountable device.

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