Single channel cartridge device for coagulation assays in fluid samples
First Claim
1. A sample analysis cartridge comprising:
- an inlet chamber configured to receive a biological sample;
a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber, the conduit comprising;
a sensor chip including a first micro-environment sensor and a second micro-environment sensor,a first reagent comprising a first enzyme substrate, the first reagent formed on and/or adjacent to the first micro-environment sensor,a second reagent comprising a second enzyme substrate, the second reagent formed on and/or adjacent to the second micro-environment sensor, anda fluidic lock valve; and
a pump configured to push the biological sample over the first micro-environment sensor and the second micro-environment sensor to the fluidic lock valve such that the biological sample is positioned over the first micro-environment sensor and the second micro-environment sensor,wherein each of the first micro-environment sensor and the second micro-environment sensor includes at least one transducer coated with a polymer layer, the first reagent is integrated within, coated over and/or positioned adjacent to the polymer layer of the first micro-environment sensor, and the second reagent is integrated within, coated over and/or positioned adjacent to the polymer layer of the second micro-environment sensor.
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Accused Products
Abstract
The present invention relates to analytical testing devices comprising a single channel with micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using a single channel with micro-environment sensors in a point of care test cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample and a conduit fluidically connected to the inlet chamber. The conduit includes a sensor chip including a first micro-environment sensor and a second microenvironment sensor, and a fluid lock valve. The sample analysis cartridge further includes a pump configured to push the biological sample over the first micro-environment sensor and the second microenvironment sensor to the fluidic lock valve such that the biological sample is positioned over the first micro-environment sensor and the second micro-environment sensor.
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Citations
7 Claims
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1. A sample analysis cartridge comprising:
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an inlet chamber configured to receive a biological sample; a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber, the conduit comprising; a sensor chip including a first micro-environment sensor and a second micro-environment sensor, a first reagent comprising a first enzyme substrate, the first reagent formed on and/or adjacent to the first micro-environment sensor, a second reagent comprising a second enzyme substrate, the second reagent formed on and/or adjacent to the second micro-environment sensor, and a fluidic lock valve; and a pump configured to push the biological sample over the first micro-environment sensor and the second micro-environment sensor to the fluidic lock valve such that the biological sample is positioned over the first micro-environment sensor and the second micro-environment sensor, wherein each of the first micro-environment sensor and the second micro-environment sensor includes at least one transducer coated with a polymer layer, the first reagent is integrated within, coated over and/or positioned adjacent to the polymer layer of the first micro-environment sensor, and the second reagent is integrated within, coated over and/or positioned adjacent to the polymer layer of the second micro-environment sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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Specification