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Combination of an insulin and a GLP-1 agonist

  • US 10,117,909 B2
  • Filed: 11/01/2016
  • Issued: 11/06/2018
  • Est. Priority Date: 10/17/2008
  • Status: Active Grant
First Claim
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1. A prefilled syringe comprising a pharmaceutical formulation, wherein the pharmaceutical formulation comprises a combination of:

  • (a) insulin glargine or a pharmaceutically acceptable salt thereof, and(b) desPro36exendin-4(1-39)-Lys6-NH2 (AVE0010) or a pharmaceutically acceptable salt thereof;

    wherein the pharmaceutical formulation has a concentration of insulin glargine that is about 100 units/mL and a concentration of AVE0010 that is about 33 μ

    g/mL; and

    wherein the prefilled syringe is configured to administer the pharmaceutical formulation at a dosage of insulin glargine between about 15 units and about 80 units and a dosage of AVE0010 between about 5 μ

    g and about 2 mg.

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