Capsule endoscope for photodynamic and sonodynamic therapy

• US 10,130,802 B2
• Filed: 10/31/2013
• Issued: 11/20/2018
• Est. Priority Date: 11/01/2012
• Status: Active Grant

• Current Assignee: Catholic University Industry Academic Cooperation Foundation
• Original Assignee: Catholic University Industry Academic Cooperation Foundation
• Inventors: Chae, Hiun Suk
• Primary Examiner(s): Leubecker, John P
• Application Number:
  US14/440,097
• Publication Number:
  US 20150283370A1
• Time in Patent Office: 1,846 Days
• CPC Class Codes: A61B 1/00087 Tools A61B17/00234 takes precedence
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 2007/0043 intra-cavitary
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/0603 for treatment of body cavities
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

A capsule endoscope for photodynamic and sonodynamic therapy is disclosed. The capsule includes: an endoscope body; a light and ultrasonic wave irradiation portion provided on the outer surface of the endoscope body and irradiating light of different wavelengths and ultrasonic waves; and a photodynamic and sonodynamic therapy portion connected to the outer surface of the endoscope body and comprising a material for photodynamic and sonodynamic therapy, wherein the photodynamic and sonodynamic therapy portion can be activated by the light and ultrasonic waves irradiated from the light and ultrasonic wave irradiation portion. The capsule endoscope can treat local bacterial infection, or diabetes, malignant diseases, chronic colitis and the like caused by a change in the number and type of intestinal floras while passing through the body in addition to carrying out diagnosis, which is the inherent function of a capsule endoscope, and thus there is no need for additional treatment and a patient can comfortably receive therapy.

Claims

1. A capsule endoscope for a photodynamic and sonodynamic therapy, comprising:

an endoscope body;

a plurality of light and ultrasonic wave radiators disposed in a form of bands surrounding a surface of the endoscope body, wherein each of the light and ultrasonic wave radiators radiate light and ultrasonic waves with different wavelengths; and

a plurality of photodynamic and sonodynamic treaters connected to the surface of the endoscope body and containing substances for a photodynamic and sonodynamic therapy,

wherein the substances are activated by light and ultrasonic waves from the light and ultrasonic wave radiators,

wherein the photodynamic and sonodynamic treaters are connected to the endoscope body by connecting fibers that are decomposed at a pH condition in an intestine.

2. The capsule endoscope of claim 1, wherein the endoscope body has the shape of a cylinder or a rugby ball.

3. The capsule endoscope of claim 1, wherein the photodynamic and sonodynamic treaters have the shape of multiple microcapsules and the substances for the photodynamic and sonodynamic therapy is at least one selected from a group consisting of a light or ultrasonic sensitizer, an antibiotic, a nano-substance, and probiotics.

4. The capsule endoscope of claim 1, wherein cameras are disposed at a front and a rear of the endoscope body.

5. A capsule endoscope for photodynamic and sonodynamic therapy, comprising:

a plurality of capsule endoscopes of claim 1; and

connectors that connect the plurality of capsule endoscopes.