Dosing regimen for missed doses for long-acting injectable paliperidone esters

  • US 10,143,693 B2
  • Filed: 04/05/2016
  • Issued: 12/04/2018
  • Est. Priority Date: 04/07/2015
  • Status: Active Grant
First Claim
Patent Images

1. A dosing regimen for administering an injectable paliperidone palmitate depot to a patient in need of treatment for psychosis, schizophrenia or bipolar disorder that has been treated with a 3-month injectable paliperidone palmitate depot (PP3M), wherein said patient had been last administered a PP3M injection more than 9 months ago, and the next scheduled maintenance dose of the PP3M should be administered to said patient, comprising:

  • (1) administering intramuscularly in the deltoid muscle of said patient a first reinitiation loading dose of 150 mg eq. of monthly injectable paliperidone palmitate depot (PP1M);

    (2) administering intramuscularly in the deltoid muscle of said patient a second reinitiation loading dose of 100 mg eq. of PP1M on about the 4th day to about the 12th day after administering said first reinitiation loading dose;

    (3) administering intramuscularly in the deltoid or gluteal muscle of said patient a first reinitiation maintenance dose of 50 mg eq. to about 150 mg eq. of PP1M on about the 23th day to about the 37th day after administering said second reinitiation loading dose;

    (4) administering intramuscularly in the deltoid or gluteal muscle of said patient a second reinitiation maintenance dose of from about 50 mg eq. to about 150 mg eq. of PP1M on about the 23rd day to about the 37th day after administering of the first reinitiation maintenance dose;

    (5) administering intramuscularly in the deltoid or gluteal muscle of said patient a third reinitiation maintenance dose of from about 50 mg eq. to about 150 mg eq. of PP1M on about the 23rd day to about the 37th day after administering of the second reinitiation maintenance dose; and

    (6) administering intramuscularly in the deltoid or gluteal muscle of said patient from about 175 mg eq. to about 525 mg eq. of PP3M on about the 23rd day to about the 37th day after administering of the last reinitiation maintenance dose of monthly injectable paliperidone palmitate.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×