Systems and methods for generating a treatment map

• US 10,152,529 B2
• Filed: 02/27/2014
• Issued: 12/11/2018
• Est. Priority Date: 08/23/2013
• Status: Active Grant

• Current Assignee: Elwha LLC (Intellectual Ventures LLC)
• Original Assignee: Elwha LLC (Intellectual Ventures LLC)
• Inventors: Hyde, Roderick A., McKnight, Gary L.
• Primary Examiner(s): Dieterle, Jennifer
• Assistant Examiner(s): Kinnard, Lisa
• Application Number:
  US14/192,680
• Publication Number:
  US 20150058368A1
• Time in Patent Office: 1,748 Days
• CPC Class Codes: A61B 5/441 Skin evaluation, e.g. for skin disorder diagnosis
• CPC Class Codes: A61B 5/443 Evaluating skin constituents, e.g. elastin, melanin, water
• CPC Class Codes: A61B 5/445 Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore
• CPC Class Codes: G06F 16/242 Query formulation
• CPC Class Codes: G06V 20/693 Acquisition
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 20/13 delivered from dispensers
• CPC Class Codes: G16H 30/20 for handling medical images, e.g. DICOM, HL7 or PACS
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Systems and methods are described for generating a treatment map based on a microbe profile, which include receiving a two-dimensional microbe profile of a skin surface of an individual, selecting one or more treatment agents from a database of treatment agents, generating the treatment map by mapping the selected one or more treatment agents to each of one or more corresponding locations on the two-dimensional microbe profile of the skin surface of the individual, and reporting the treatment map to a user.

Claims

1. A system for generating a treatment map, comprising:

a digital two-dimensional microbe profile of a skin surface of an individual'"'"'s face the digital two-dimensional microbe profile including a two-dimensional spatial distribution, relative abundance, and identity of one or more types of microbes at each of one or more locations on the skin surface of the individual'"'"'s face overlaid with a feature map of the skin surface of the individual'"'"'s face;

a database of treatment agents;

a computing device including a processor and circuitry, the circuitry including

circuitry configured to receive the digital two-dimensional microbe profile of the skin surface of the individual'"'"'s face;

circuitry configured to select one or more treatment agents from the database of treatment agents based on the two-dimensional spatial distribution, the relative abundance, and the identity of the one or more types of microbes at each of the one or more locations on the skin surface of the individual'"'"'s face;

circuitry configured to map the one or more treatment agents selected to treat at least one of the one or more types of microbes at each of the one or more locations on the skin surface of the individual'"'"'s face to each of one or more corresponding locations on the feature map associated with the digital two-dimensional microbe profile;

circuitry configured to generate a personalized treatment map including a two-dimensional spatial distribution of the one or more treatment agents selected for application at each of the one or more locations on the skin surface of the individual'"'"'s face overlaid with the feature map of the skin surface of the individual'"'"'s face; and

circuitry configured to report the generated personalized treatment map to a user.

2. The system of claim 1, wherein the circuitry configured to receive the digital two-dimensional microbe profile comprises circuitry configured to receive the digital two-dimensional microbe profile from a microbe profiling device.

3. The system of claim 1, wherein the feature map of the skin surface of the individual'"'"'s face includes at least one of an image map, a fiducial marker map, or a coordinate map of the skin surface of the individual'"'"'s face.

4. The system of claim 1, wherein the circuitry configured to select the one or more treatment agents from the database of treatment agents comprises circuitry configured to select at least one of one or more probiotics, one or more prebiotics, or one or more of an antimicrobial agent, a therapeutic agent, or a chemotherapeutic agent from the database of treatment agents based on the two-dimensional spatial distribution, the relative abundance, and the identity of the one or more types of microbes at each of the one or more locations on the skin surface of the individual'"'"'s face.

5. The system of claim 1, further comprising:

circuitry configured to compare the selected one or more treatment agents with a second database of treatment agents identified as compatible or non-compatible with the individual'"'"'s face to determine if the selected one or more treatment agents is compatible or non-compatible with the individual'"'"'s face.

6. The system of claim 1, further comprising:

circuitry configured to add a name, a dose, and a dosing schedule of each of the selected one or more treatment agents at each of the one or more corresponding locations on the feature map associated with the digital two-dimensional microbe profile.

7. The system of claim 1, further comprising:

circuitry configured to incorporate at least one of a spatial or a temporal delivery route into the personalized treatment map based upon a correlation between microbe profiles at each of one or more different locations and the selected one or more treatment agents for delivery at each of said one or more different locations.

8. The system of claim 1, wherein the circuitry configured to report the generated personalized treatment map to the user comprises circuitry configured to report the generated personalized treatment map to the user on at least one of a display, a printout, or a second computing device.

9. The system of claim 1, further comprising:

circuitry configured to transmit information associated with the generated personalized treatment map to at least one of a remote source, a second computing device, a skin-treatment delivery device, or a skin-treatment delivery system.

10. The system of claim 1, further comprising:

a skin treatment delivery device including

one or more location-capture components including circuitry configured to measure a feature of a location on the skin surface of the individual'"'"'s face;

a treatment unit including one or more treatment agent reservoirs, each of the one or more treatment agent reservoirs including a controllable valve;

wherein the computing device is operably coupled to the one or more location-capture components and the controllable valve of each of the one or more treatment agent reservoirs of the skin treatment delivery device, and

wherein the computing device includes

circuitry configured to receive information associated with the measured feature of the location on the skin surface of the individual'"'"'s face from the one or more location-capture components;

circuitry configured to map the received information associated with the measured feature of the location on the skin surface of the individual'"'"'s face to the feature map of the skin surface of the individual'"'"'s face associated with the personalized treatment map;

circuitry configured to identify at least one of the one or more treatment agents from the personalized treatment map for application at said location on the skin surface of the individual'"'"'s face based on the mapping of the measured feature to the feature map of the skin surface of the individual'"'"'s face; and

circuitry configured to actuate the controllable valve of at least one of the one or more treatment agent reservoirs to modulate release of the identified at least one of the one or more treatment agents for application at said location on the skin surface of the individual'"'"'s face.

11. A system for generating a treatment map, comprising:

a database of treatment agents for application to a skin surface to treat one or more types of microbes;

a computing device including a processor and memory; and

circuitry operably coupled to the computing device and configured to generate the treatment map, wherein the circuitry includes

circuitry configured to receive a digital two-dimensional microbe profile of a skin surface of an individual'"'"'s face, the digital two-dimensional microbe profile including a two-dimensional spatial distribution, relative abundance, and identity of one or more types of microbes at each of one or more locations on the skin surface of the individual'"'"'s face overlaid with a feature map of the skin surface of the individual'"'"'s face;

circuitry configured to select one or more treatment agents from the database of treatment agents based on the two-dimensional spatial distribution, the relative abundance, and the identity of the one or more types of microbes at each of the one or more locations on the skin surface of the individual'"'"'s face;

circuitry configured to map the one or more treatment agents selected to treat at least one of the one or more types of microbes at each of the one or more locations on the skin surface of the individual'"'"'s face to each of one or more corresponding locations on the feature map associated with the digital two-dimensional microbe profile;

circuitry configured to generate a personalized treatment map including a two-dimensional spatial distribution of the one or more treatment agents selected for application at each of the one or more locations on the skin surface of the individual'"'"'s face overlaid with the feature map of the skin surface of the individual'"'"'s face; and

circuitry configured to report the generated personalized treatment map to a user.

12. The system of claim 11, wherein the database of treatment agents for application to the skin surface to treat one or more types of microbes is incorporated into the computing device.

13. The system of claim 11, wherein the database of treatment agents for application to the skin surface to treat one or more types of microbes includes one or more probiotics, one or more prebiotics, or one or more of an antimicrobial agent, a therapeutic agent, or a chemotherapeutic agent for application to the skin surface to treat one or more types of microbes.

14. The system of claim 11, wherein the circuitry configured to receive the digital two-dimensional microbe profile comprises circuitry configured to receive the digital two-dimensional microbe profile from a microbe profiling device.

15. The system of claim 11, wherein the feature map of the skin surface of the individual'"'"'s face is an image map of the skin surface of the individual'"'"'s face.

16. The system of claim 11, wherein the feature map of the skin surface of the individual'"'"'s face is a fiducial marker map of the skin surface of the individual'"'"'s face.

17. The system of claim 11, wherein the feature map of the skin surface of the individual'"'"'s face is a coordinate map of the skin surface of the individual'"'"'s face.

18. The system of claim 11, wherein the circuitry configured to select the one or more treatment agents from the database of treatment agents comprises circuitry configured to select at least one of one or more probiotics, one or more prebiotics, or one or more of an antimicrobial agent, a therapeutic agent, or a chemotherapeutic agent from the database of treatment agents based on the two-dimensional spatial distribution, the relative abundance, and the identity of the one or more types of microbes at each of the one or more locations on the skin surface of the individual'"'"'s face.

19. The system of claim 11, further comprising:

a second database of treatment agents identified as compatible or non-compatible with the individual'"'"'s face; and

circuitry configured to determine if the selected one or more treatment agents are compatible or non-compatible with the individual'"'"'s face.

20. The system of claim 11, further comprising:

circuitry configured to add a name, a dose, and a dosing schedule of each of the selected one or more treatment agents at each of the one or more corresponding locations on the feature map associated with the digital two-dimensional microbe profile.

21. The system of claim 11, wherein the circuitry configured to report the generated personalized treatment map to the user comprises circuitry configured to report the generated personalized treatment map to the user on at least one of a display associated with the computing device, a printout, or a second computing device.

22. The system of claim 11, wherein the circuitry configured to report the generated personalized treatment map to the user comprises circuitry configured to report the generated personalized treatment map to the user on a personal communication device.

23. The system of claim 11, further comprising:

circuitry configured to transmit information associated with the generated personalized treatment map to a skin-treatment delivery system.

24. The system of claim 11, further comprising:

a skin treatment delivery device including

one or more location-capture components including circuitry configured to measure a feature of a location on the skin surface of the individual'"'"'s face;

a treatment unit including one or more treatment agent reservoirs, each of the one or more treatment agent reservoirs including a controllable valve;

wherein the computing device is operably coupled to the one or more location-capture components and the controllable valve of each of the one or more treatment agent reservoirs of the skin treatment delivery device, and

wherein the computing device includes

circuitry configured to receive information associated with the measured feature of the location on the skin surface of the individual'"'"'s face from the one or more location-capture components;

circuitry configured to map the received information associated with the measured feature of the location on the skin surface of the individual'"'"'s face to the feature map of the skin surface of the individual'"'"'s face associated with the personalized treatment map;

circuitry configured to identify at least one of the one or more treatment agents from the personalized treatment map for application at said location on the skin surface of the individual'"'"'s face based on the mapping of the measured feature to the feature map of the skin surface of the individual'"'"'s face; and

circuitry configured to actuate the controllable valve of at least one of the one or more treatment agent reservoirs to modulate release of the identified at least one of the one or more treatment agents for application at said location on the skin surface of the individual'"'"'s face.