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Immunotherapeutic methods using irreversible electroporation

  • US 10,154,874 B2
  • Filed: 01/26/2018
  • Issued: 12/18/2018
  • Est. Priority Date: 04/29/2008
  • Status: Active Grant
First Claim
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1. A method for treating tissue comprising:

  • placing a probe in tissue within a human body, wherein the probe has at least a first electrode;

    applying a plurality of electrical pulses through the first electrode and a second electrode, wherein the electrical pulses have a pulse length of 10 microseconds or less and there is a delay between two adjacent pulses;

    causing irreversible electroporation (IRE) of the tissue within a target ablation zone; and

    administering one or more exogenous or endogenous agents into the tissue within the target ablation zone;

    thereby stimulating or otherwise modulating an immune system response within the body.

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