Immunotherapeutic methods using irreversible electroporation
First Claim
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1. A method for treating tissue comprising:
- placing a probe in tissue within a human body, wherein the probe has at least a first electrode;
applying a plurality of electrical pulses through the first electrode and a second electrode, wherein the electrical pulses have a pulse length of 10 microseconds or less and there is a delay between two adjacent pulses;
causing irreversible electroporation (IRE) of the tissue within a target ablation zone; and
administering one or more exogenous or endogenous agents into the tissue within the target ablation zone;
thereby stimulating or otherwise modulating an immune system response within the body.
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Abstract
Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.
797 Citations
30 Claims
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1. A method for treating tissue comprising:
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placing a probe in tissue within a human body, wherein the probe has at least a first electrode; applying a plurality of electrical pulses through the first electrode and a second electrode, wherein the electrical pulses have a pulse length of 10 microseconds or less and there is a delay between two adjacent pulses; causing irreversible electroporation (IRE) of the tissue within a target ablation zone; and administering one or more exogenous or endogenous agents into the tissue within the target ablation zone; thereby stimulating or otherwise modulating an immune system response within the body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for treating tissue within a human comprising:
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placing a probe in tissue within a human, wherein the probe has at least a first electrode; applying a plurality of electrical pulses through the first electrode and a second electrode; causing irreversible electroporation (IRE) of the tissue within a target ablation zone in an amount sufficient to promote an immune response; and administering one or more exogenous or endogenous agents to the human to further stimulate the immune system. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method for treating tissue comprising:
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placing a probe in tissue within a human body, wherein the probe has at least a first electrode; applying a plurality of electrical pulses through the first electrode and a second electrode, wherein the electrical pulses have a pulse length of 10 microseconds or less and there is a delay between two adjacent pulses; and causing irreversible electroporation (IRE) of the tissue within a target ablation zone in an amount sufficient to promote an immune response by way of immune cells that respond to tissue injury resulting from the IRE. - View Dependent Claims (30)
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Specification