Methods of administering amantadine

  • US 10,154,971 B2
  • Filed: 06/17/2014
  • Issued: 12/18/2018
  • Est. Priority Date: 06/17/2013
  • Status: Active Grant
First Claim
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1. A method of reducing OFF time in a patient with Parkinson'"'"'s disease (PD), wherein the patient is being treated with a Parkinson'"'"'s medication, the method comprising:

  • (1) orally administering to said patient once daily for at least one week a first composition comprising 85 mg to 170 mg amantadine, or a pharmaceutically acceptable salt thereof, and at least one excipient that modifies the release of at least a portion of the amantadine or pharmaceutically acceptable salt thereof to provide an extended release form; and

    thereafter(2) orally administering to said patient once daily a second composition comprising 260 mg to 380 mg amantadine, or a pharmaceutically acceptable salt thereof, and at least one excipient that modifies the release of at least a portion of the amantadine or pharmaceutically acceptable salt thereof to provide an extended release form;

    wherein OFF time in the patient is reduced after at least 7 weeks of administering the second composition once daily to the patient; and

    wherein the plasma concentration of amantadine in the patient is increased less than 10% at 1 hour after administration of the first or second composition.

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