Obtaining cardiovascular parameters using arterioles related transient time

• US 10,165,955 B2
• Filed: 02/03/2015
• Issued: 01/01/2019
• Est. Priority Date: 02/06/2014
• Status: Active Grant

• Current Assignee: Eilon Rahman, Reuven Gladshtein
• Original Assignee: Eilon Rahman, Reuven Gladshtein
• Inventors: Gladshtein, Reuven, Rahman, Eilon
• Primary Examiner(s): Flory, Christopher A
• Application Number:
  US14/612,695
• Publication Number:
  US 20160367154A1
• Time in Patent Office: 1,428 Days
• Field of Search: 600479
• CPC Class Codes: A61B 2560/0431 Portable apparatus, e.g. comprising a handle or case
• CPC Class Codes: A61B 3/1233 for measuring blood flow, e.g. at the retina
• CPC Class Codes: A61B 3/1241 specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/02438 with portable devices, e.g. worn by the patient
• CPC Class Codes: A61B 5/0245 by using sensing means generating electric signals, i.e. ECG signals
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14555 specially adapted for the eye fundus
• CPC Class Codes: A61B 5/14556 by fluorescence A61B5/14555 takes precedence
• CPC Class Codes: A61B 5/4238 stomach
• CPC Class Codes: A61B 5/4255 Intestines, colon or appendix
• CPC Class Codes: A61B 5/6821 Eye
• CPC Class Codes: A61B 5/6823 : Trunk, e.g., chest, back, abdomen, hip
• CPC Class Codes: A61B 5/6824 : Arm or wrist
• CPC Class Codes: A61B 5/6871 : Stomach
• CPC Class Codes: A61B 5/6873 : Intestine
• CPC Class Codes: F16L 33/30 : comprising parts inside the hoses only F16L33/24 takes precedence

Abstract

Methods for monitoring equivalent inner diameter of arterioles by measuring blood pressure wave transient time from small arteries to arterioles and calculating, from the transient time and concurrently measured heart rate values, an equivalent inner diameter of arterioles.

Claims

1. A method for estimation of inner diameter of arterioles in measured body part, the method comprising:

obtaining a first pressure wave signal from a first tissue volume beneath the surface of a part of a subject'"'"'s body, containing blood vessels;

wherein contribution in the first signal from artery-like blood vessels predominates over contribution from arteriole-like blood vessels;

obtaining a second pressure wave signal from a second tissue volume beneath the surface of the part of the subject'"'"'s body, containing blood vessels;

wherein contribution in the second signal from arteriole-like blood vessels predominates over contribution from artery-like blood vessels;

obtaining at least one concurrent heart rate value;

finding time delay values between the first signal and the second signal; and

using said at least one value of the time delay values and said at least one heart rate value to calculate an equivalent inner diameter of said arterioles.

2. The method of claim 1, wherein said first tissue volume is from a characteristic depth of arteries beneath the surface of said part of subject'"'"'s body.

3. The method according to claim 2, wherein said characteristic depth of said first tissue volume is between 7 and 9 mm under the skin of the subject'"'"'s body.

4. The method according to claim 1, wherein the time delay between said first signal and said second signal is within a range from 9.23 to 93.94 milliseconds.

5. The method according to claim 1, wherein the time delay between said first signal and said second signal is in range from 19.47 to 91.11 milliseconds.

6. The method according to claim 1, wherein said first signal is obtained by a light of infrared color.

7. The method according to claim 1, wherein said first and second volumes are related to the same peripheral body part.

8. The method according to claim 1, wherein estimation of an equivalent inner diameter of said arterioles also uses blood viscosity value of measured subject.

9. The method according to claim 1, further comprising:

obtaining information about at least one parameter having a physiological influence on the subject over time;

finding correlation between changes over time of said at least one parameter and changes over time in said estimated equivalent inner diameter value of arterioles.

10. The method according to claim 9, wherein said parameter represents a substance entering to subject body.

11. The method according to claim 9, wherein said parameter is a behavioral parameter of the subject.

12. The method according to claim 1, wherein estimation equivalent inner diameter value of arterioles is done, after all said first and second signals are collected.

13. The method of claim 1, wherein said second tissue volume is from characteristic depth of arterioles beneath the surface of said part of subject'"'"'s body.

14. The method according to claim 13, wherein said characteristic depth of said second tissue volume is between 3 and 4 mm under the skin of the subject'"'"'s body.

15. The method according to claim 1, wherein said second signal is obtained by a light of green color.