Formulations and methods of manufacturing formulations for use in colonic evacuation
First Claim
Patent Images
1. A coated tablet, comprising:
- an intra-granular fraction combined with an extra-granular fraction, and a coating layer,wherein the intra-granular fraction includes granules comprising micronized sodium picosulfate, microcrystalline cellulose, magnesium oxide, and crospovidone, and wherein the intra-granular fractions excludes sodium starch glycolate,wherein the extra-granular fraction includes one or more organic acids, microcrystalline cellulose, and crospovidone, and wherein the extra-granular fraction excludes sodium starch glycolate and magnesium stearate,wherein the organic acid is one of ascorbic acid, citric acid, tartaric acid, or combinations thereof, andwherein the coating layer delays dissolution beyond the mouth of a patient.
2 Assignments
0 Petitions
Accused Products
Abstract
Formulations and methods of manufacturing formulations for use in colonic evacuation are disclosed herein, in an embodiment, a solid dosage formulation includes an intra-granular fraction intermingled with an extra-granular fraction, wherein the intra-granular fraction includes granules comprising at least one osmotic evacuant agent, at least one antacid, and a first pharmaceutically acceptable excipient component, and wherein the extra-granular fraction includes one or more organic acids, a non-metallic lubricating element, and a second pharmaceutically acceptable excipient component.
86 Citations
5 Claims
-
1. A coated tablet, comprising:
- an intra-granular fraction combined with an extra-granular fraction, and a coating layer,
wherein the intra-granular fraction includes granules comprising micronized sodium picosulfate, microcrystalline cellulose, magnesium oxide, and crospovidone, and wherein the intra-granular fractions excludes sodium starch glycolate, wherein the extra-granular fraction includes one or more organic acids, microcrystalline cellulose, and crospovidone, and wherein the extra-granular fraction excludes sodium starch glycolate and magnesium stearate, wherein the organic acid is one of ascorbic acid, citric acid, tartaric acid, or combinations thereof, and wherein the coating layer delays dissolution beyond the mouth of a patient. - View Dependent Claims (2, 3, 4, 5)
- an intra-granular fraction combined with an extra-granular fraction, and a coating layer,
Specification