Apparatus and method for optimized stimulation of a neurological target

• US 10,166,392 B2
• Filed: 06/04/2015
• Issued: 01/01/2019
• Est. Priority Date: 07/30/2008
• Status: Active Grant

• Current Assignee: Ecole polytechnique fãdãrale de lausanne epfl (Schweizerische Eidgenossenschaft)
• Original Assignee: Ecole polytechnique fãdãrale de lausanne epfl (Schweizerische Eidgenossenschaft)
• Inventors: Mercanzini, Andre, Renaud, Philippe
• Primary Examiner(s): Hulbert, Amanda P
• Assistant Examiner(s): Edwards, Philip C
• Application Number:
  US14/731,296
• Publication Number:
  US 20150335896A1
• Time in Patent Office: 1,307 Days
• Field of Search: 607 45
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36125 Details of circuitry or electric components
• CPC Class Codes: A61N 1/36171 Frequency
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration

Abstract

A preferred frequency is identified, being usable to stimulate a neurological target within a mammalian body using at least one microelectrode positioned at or near the target. To establish efficient and effective stimulation, an impedance analyzer is provided for measuring electrical impedance values indicative of a microelectrode-tissue interface across a range of different frequencies. A preferred one of the measured electrical impedance values is identified as being closest to a pure resistance. The neurological target can then be stimulated at or near the frequency associated with the preferred impedance value (peak resistance frequency), thereby promoting desirable traits, such as optimum charge transfer, minimum signal distortion, increased stimulation efficiency, and prevention of microelectrode corrosion. The peak resistance frequency can be used to determine an preferred pulse shape. A target can be identified by microelectrode measurements of neuronal activity and/or impedance magnitude at peak resistance frequency.

Claims

1. An implantable signal router, comprising:

a plurality of inputs each configured to receive signals from an implantable stimulator;

a plurality of outputs each configured to electrically communicate with a respective microelectrode; and

a routing circuit comprising a plurality of switches, the routing circuit coupled with each of the plurality of inputs and each of the plurality of outputs, the routing circuit configured to;

selectively interconnect, with at least one switch of the plurality of switches, a first of the plurality of inputs with a first two or more outputs of the plurality of outputs;

route a first signal from the first of the plurality of inputs to the first two or more outputs of the plurality of outputs;

selectively interconnect, with a second at least one switch of the plurality of switches, a second of the plurality of inputs with a second two of more outputs of the plurality of outputs; and

route a second signal from the second of the plurality of inputs to the second two or more outputs of the plurality of outputs.

2. The implantable signal router of claim 1, wherein the plurality of switches are configured in an electrically conductive branch circuit.

3. The implantable signal router of claim 1, wherein the plurality of switches are at least one of micro-machined reed relays and transistors.

4. The implantable signal router of claim 1, wherein a number of the plurality of inputs is less than a number of the plurality of outputs.

5. The implantable signal router of claim 1, further comprising a signal conditioner circuit configured to condition the received signal from the implantable stimulator.

6. The implantable signal router of claim 1, comprising:

a signal conditioner circuit configured to filter the received signal from the implantable stimulator or to gain adjust the received signal.

7. The implantable signal router of claim 1, wherein the implantable signal router is a component of the implantable stimulator.

8. The implantable signal router of claim 1, comprising:

an impedance analyzer configured to measure impedance values received at the plurality of outputs, the impedance values measuring an interface between each of the respective microelectrodes and a tissue.

9. The implantable signal router of claim 8, wherein the routing circuit is configured to selectively interconnect at least one of the plurality of outputs to the impedance analyzer.

10. The implantable signal router of claim 1, comprising:

a telemetry and control module configured to wirelessly communicate with an extra-corporeal unit.

11. A method, comprising:

selectively interconnecting, with at least one switch, a first of a plurality of inputs of an implantable signal router with a first two or more outputs of a plurality of outputs of the implantable signal router;

receiving, by the one of the plurality of inputs, a signal generated by an implantable simulator;

routing the signal from the first of the plurality of inputs to the first two or more outputs of the plurality of outputs;

outputting the signal from the first two or more outputs of the plurality of outputs;

selectively interconnecting, with a second at least one switch, a second of the plurality of inputs of the implantable signal router with a second two of more outputs of the plurality of outputs of the implantable signal router;

receiving, by the one of the plurality of inputs, a second signal generated by the implantable simulator;

routing the second signal from the second of the plurality of inputs to the second two or more outputs of the plurality of outputs; and

outputting the second signal from the second two or more outputs of the plurality of outputs.

12. The method of claim 11, wherein the at least one switch is configured in an electrically conductive branch circuit.

13. The method of claim 11, wherein the at least one switch is at least one of a micro-machined reed relay and a transistor.

14. The method of claim 11, wherein a number of the plurality of inputs is less than a number of the plurality of outputs.

15. The method of claim 11, comprising:

conditioning, with a signal conditioner circuit, the received signal from the implantable stimulator.

16. The method of claim 15, wherein conditioning the received signal comprises at least one of filtering the received signal or gain adjusting the received signal.

17. The method of claim 11, wherein the implantable signal router is a component of the implantable stimulator.

18. The method of claim 11, comprising:

measuring impedance values from at least one of the plurality of outputs, the impedance values measuring an interface between each of the respective microelectrodes and a tissue.

19. The method of claim 18, comprising:

selectively interconnecting at least one of the plurality of outputs to the impedance analyzer.