C1-INH compositions and methods for the prevention and treatment of disorders associated with C1 esterase inhibitor deficiency

  • US 10,201,595 B2
  • Filed: 12/11/2017
  • Issued: 02/12/2019
  • Est. Priority Date: 03/15/2013
  • Status: Active Grant
First Claim
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1. A method for prophylactic treatment of hereditary angioedema (HAE) comprising subcutaneously administering to a subject in need thereof a pharmaceutical composition comprising C1 esterase inhibitor, sodium citrate, and having a pH ranging from 6.5-8.0, wherein the C1 esterase inhibitor has a concentration of about 400-600 U/mL, and wherein the C1 esterase inhibitor comprises the amino acid sequence of residues 23 to 500 of SEQ ID NO:

  • 1, and wherein the administration of the composition increases the level of the C1 esterase inhibitor in the blood of the subject to at least about 0.4 U/mL.

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