Anti-TNF compounds
First Claim
Patent Images
1. A compound comprising the structure depicted in FIG. 7, SEQ ID NO. 16, or salts thereof, of 18-19 nucleotides in length wherein the compound includes at least one phosphorothioate modification.
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Abstract
TNFα antisense oligonucleotides are provided herein. Methods of treating TNFα diseases or disorders using the TNFα antisense oligonucleotides and related products are provided.
96 Citations
42 Claims
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1. A compound comprising the structure depicted in
FIG. 7 , SEQ ID NO. 16, or salts thereof, of 18-19 nucleotides in length wherein the compound includes at least one phosphorothioate modification.
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13. An oligonucleotide comprising mUmGmGmGmAmGT*A*G*A*T*G*mAmGmGmUmAmC (SEQ ID NO. 16), wherein the oligonucleotide is 18 nucleotides in length, wherein m is a 2′
- O methyl, and wherein * is a phosphorothioate modification.
- View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. An oligonucleotide comprising 5′
- TGGGAGTAGATGAGGTAC 3′
(SEQ ID NO.
4), wherein the oligonucleotide is 18-19 nucleotides in length, wherein 4-6 nucleotides at the 5′
end and 4-6 nucleotides at the 3′
end of the oligonucleotide include a 2′
O methyl, and wherein 4-10 nucleotides have a phosphorothioate modification. - View Dependent Claims (25, 26, 33, 34)
- TGGGAGTAGATGAGGTAC 3′
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27. A stable self-assembling nanostructure, comprising
an antisense oligonucleotide of 18-19 nucleotides in length comprising TGGGAGTAGATGAGGTAC (SEQ ID NO. 4), wherein the antisense oligonucleotide is associated with a core.
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31. A stable self-assembling nanostructure, comprising an antisense oligonucleotide of 18-19 nucleotides in length comprising TGGGAGTAGATGAGGTAC (SEQ ID NO. 4), wherein a hydrophobic group at the 3′
- or 5′
terminus self-associates to form the core of the nanostructure in water or other suitable solvents. - View Dependent Claims (42)
- or 5′
Specification