Atrial arrhythmia episode detection in a cardiac medical device

• US 10,213,125 B2
• Filed: 01/23/2015
• Issued: 02/26/2019
• Est. Priority Date: 01/23/2015
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Cao, Jian, DeGroot, Paul J
• Primary Examiner(s): Dietrich, Joseph M
• Application Number:
  US14/604,468
• Publication Number:
  US 20160213275A1
• Time in Patent Office: 1,495 Days
• CPC Class Codes: A61B 5/35 by template matching
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence

Abstract

A method and medical device for detecting a cardiac event that includes sensing a cardiac signal, determining RR-intervals in response to the sensed cardiac signal, detecting a cardiac event in response to the RR-intervals, iteratively sensing a predetermined number of P-waves in response to detecting the cardiac event, and confirming the cardiac event in response to the iteratively sensed P-waves.

Claims

1. A method of detecting an atrial fibrillation (AF) event in a medical device, comprising:

sensing a cardiac signal;

identifying a plurality of R-waves in the cardiac signal;

determining a plurality of RR-intervals based on the plurality of identified R-waves in the sensed cardiac signal;

detecting the AF event based on at least the plurality of determined RR-intervals;

iteratively sensing a predetermined number of P-waves in response to detecting the AF event;

determining one or more P-wave parameters associated with each of the iteratively sensed predetermined number of P-waves; and

confirming the AF event based on the P-wave parameters of the iteratively sensed predetermined number of P-waves.

2. The method of claim 1, further comprising :

determining relative changes of the P-waves based on the determined P-wave parameters;

determining whether each of the P-waves match within a match threshold based on the determined relative changes; and

updating a counter in response to each of the P-waves matching within the match threshold, wherein confirming the AF event comprises confirming the AF event in response to the counter exceeding a counter threshold during a predetermined time period.

3. The method of claim 2, wherein determining relative changes of the P-waves comprises:

determining one or more of;

a width change for each of the P-waves;

an amplitude change for each of the P-waves;

or

a magnitude change for each of the P-waves; and

determining the relative changes of the P-waves based on the one or more of the width change the amplitude change or the magnitude change.

4. The method of claim 1, further comprising:

determining a P-wave window associated with each of identified R-waves; and

adjusting the P-waves within each of the determined P-wave windows;

wherein determining the one or more P-wave parameters comprises determining the one or more parameters associated with each of the adjusted P-waves.

5. The method of claim 4, further comprising:

determining, for each of the P-waves, a maximum amplitude;

determining, for each of the P-waves, a first minimum baseline point and a second minimum baseline point as a portion of the maximum amplitude;

determining, for each of the P-waves, an area based on a baseline extending between the first minimum baseline point and the second minimum baseline point;

normalizing each of the P-waves based on the area and the baseline; and

confirming the AF event using the normalized P-waves.

6. The method of claim 5, wherein normalizing the P-waves comprises:

determining a normalized amplitude of each of the P-waves; and

determining a center of the area of each of the normalized P-waves based on a width of the baseline and the normalized amplitude.

7. The method of claim 4, wherein determining relative changes of the P-waves comprises:

determining one or more of;

a width change for each of the P-waves;

an amplitude change for each of the P-waves;

or

a magnitude change for each of the P-waves; and

determining the relative changes of the P-waves based on the one or more of the width change the amplitude change and the magnitude change.

8. The method of claim 1, wherein iteratively sensing a predetermined number of P-waves in response to detecting the AF event comprises:

determining second RR-intervals in response to the sensed cardiac signal subsequent to detecting the AF event;

determining second P-wave parameters associated with P-waves determined in response to the second RR-interval;

determining relative changes of the second P-waves in response to the determined second P-wave parameters;

determining whether each of the second P-waves match within a match threshold in response to the determined relative changes; and

updating a counter in response to each of the P-waves matching within the match threshold, wherein the AF event is confirmed in response to the counter exceeding a counter threshold during a predetermined time period.

9. The method of claim 1, further comprising controlling, by the medical device, the delivery of a therapy based on the confirmation of the AF event.

10. A medical device for detecting an AF event, comprising:

a plurality of electrodes sensing a cardiac signal; and

a processor configured to identify a plurality of R-waves in the cardiac signal, determine a plurality of RR-intervals in based on the plurality of identified R-waves the sensed cardiac signal, detect the AF based on at least the plurality of determined RR-intervals, iteratively sense a predetermined number of P-waves in response to detecting the AF event, determine one or more P-wave parameters associated with each of the iteratively sensed predetermined number of P-waves and confirm the AF event based on the P-wave parameters of the iteratively sensed predetermined number of P-waves.

11. The medical device of claim 10, wherein the processor is further configured to determine relative changes of the P-waves based on the determined P-wave parameters, determine whether each of the P-waves match within a match threshold based on the determined relative changes, and update a counter in response to each of the P-waves matching within the match threshold, wherein the AF event is confirmed in response to the counter exceeding a counter threshold during a predetermined time period.

12. The medical device of claim 11, wherein the processor is further configured to determine one or more of a width change for each of the P-waves, an amplitude change for each of the P-waves, or a magnitude change for each of the P-waves and determine the relative changes of the P-waves based on the one or more of the width change, the amplitude change, or the magnitude change.

13. The medical device of claim 10, wherein the processor is further configured to determine a P-wave window associated with each of identified R-waves, adjust the P-waves within each of the determined P-wave windows, and determine the one or more P-wave parameters associated with each of the adjusted P-waves.

14. The medical device of claim 13, wherein the processor is further configured to determine, for each of the P-waves, a maximum amplitude, determine, for each of the P-waves, a first minimum baseline point and a second minimum baseline point as a portion of the maximum amplitude for each of the P-waves, an area based on a baseline extending between the first minimum baseline point and the second minimum baseline point, normalize each of the P-waves based on the area and the baseline, and confirm the AF event based on the normalized P-wave.

15. The medical device of claim 14, wherein the processor is further configured to determine a normalized amplitude of each of the P-waves, and determine a center of area of the area of each of the normalized P-waves based on a width of the baseline and the normalized amplitude.

16. The medical device of claim 13, wherein the processor is further configured to determine one or more of a width change for each of the P-waves, an amplitude change for each of the P-waves, or a magnitude change for each of the P-waves and determine the relative changes of the P-waves based on the one or more of the width change, the amplitude change, or the magnitude change.

17. The medical device of claim 10, wherein the processor is further configured to determine second RR-intervals in response to the sensed cardiac signal subsequent to detecting the AF event, determine second P-wave parameters associated with P-waves determined in response to the second RR-interval, determine relative changes of the second P-waves in response to the determined second P-wave parameters, determine whether each of the second P-waves match within a match threshold in response to the determined relative changes, and update a counter in response to each of the P-waves matching within the match threshold, wherein the AF event is confirmed in response to the counter exceeding a counter threshold during a predetermined time period.

18. The medical device of claim 10, wherein the processor is further configured to control the delivery of a therapy based on the confirmation of the AF event.

19. A non-transitory, computer-readable storage medium storing instructions for causing a processor included in a medical device to perform a method for determining an atrial fibrillation (AF) event, the method comprising:

sensing a cardiac signal;

identifying a plurality of R-waves in the cardiac signal;

determining a plurality of RR-intervals based on the plurality of identified R-waves in the sensed cardiac signal;

detecting the AF event based on at least the plurality of determined RR-intervals;

iteratively sensing a predetermined number of P-waves in response to detecting the AF event;

determining one or more P-wave parameters associated with each of the iteratively sensed predetermined number of P-waves; and

confirming the AF event based on the P-wave parameters of the iteratively sensed predetermined number of P-waves.

20. A cardiac medical device for detecting a cardiac event and delivering therapy for treating atrial fibrillation, comprising:

an electrode to sense a cardiac signal associated only with a ventricle of a heart and deliver a therapy to the heart;

a processor configured to determine RR-intervals in response to the sensed cardiac signal, detect a cardiac event in response to the RR-intervals, iteratively sense a predetermined number of P-waves in response to detecting the cardiac event, and confirm the cardiac event in response to the iteratively sensed P-waves; and

an output circuit to deliver therapy to the heart via the electrode in response to the confirming the cardiac event.

21. The medical device of claim 20, wherein the processor is further configured to determine whether atrial fibrillation is occurring in response to the sensed cardiac signal, and deliver ventricular pacing therapy via the output circuit during the detecting a cardiac event.

22. The medical device of claim 21, wherein the processor is further configured to determine R-waves associated with the RR-intervals, determine P-waves in response to the determined R-waves, determine parameters associated with each P-wave, determine relative changes of the P-waves in response to the determined parameters, and determine whether each of the P-waves match within a match threshold in response to the determined relative changes.

23. The medical device of claim 22, wherein the processor is further configured to determine P-wave windows in response to the determined R-waves, adjust P-waves within the P-wave windows, and determine the P-wave parameters in response to the adjusted P-waves.

24. The medical device of claim 23, wherein the processor is further configured to determine a maximum amplitude of each of the P-waves, determine, for each of the P-waves, a first minimum baseline point and a second minimum baseline point as a portion of the maximum amplitude, determine an area of each of the P-waves in response to a baseline extending between the first minimum baseline point and the second minimum baseline point, normalize the P-waves in response to the area and the baseline, and confirm the cardiac event in response to the normalized P-wave.

25. The medical device of claim 24, wherein the processor is further configured to determine a normalized amplitude of each of the P-waves, and determine a center of area of the normalized P-wave in response to a width of the baseline and the normalized amplitude.