Devices, systems and methods for locating and interacting with medicament delivery systems

• US 10,229,578 B2
• Filed: 09/25/2017
• Issued: 03/12/2019
• Est. Priority Date: 12/27/2012
• Status: Active Grant

• Current Assignee: Kaleo, Inc.
• Original Assignee: Kaleo, Inc.
• Inventors: Edwards, Eric S., Edwards, Evan T., Licata, Mark J., Meyers, Paul F.
• Primary Examiner(s): Hunnings, Travis R
• Application Number:
  US15/714,197
• Publication Number:
  US 20180033286A1
• Time in Patent Office: 533 Days
• CPC Class Codes: A61M 11/007 Syringe-type or piston-type sprayers or atomisers
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 15/0001 Details of inhalators; Constructional features thereof
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2205/14 Detection of the presence or absence of a tube, a connector or a container in an apparatus
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 2205/3553 remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3561 local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/43 making noise when used correctly
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/582 by tactile feedback
• CPC Class Codes: A61M 2205/583 : by visual feedback
• CPC Class Codes: A61M 2205/587 : Lighting arrangements
• CPC Class Codes: A61M 2205/8206 : battery-operated
• CPC Class Codes: A61M 2205/8212 : with means or measures taken for minimising energy consumption
• CPC Class Codes: A61M 2230/04 : Heartbeat characteristics, e.g. ECG, blood pressure modulation
• CPC Class Codes: A61M 2230/20 : Blood composition characteristics
• CPC Class Codes: A61M 2230/201 : Glucose concentration
• CPC Class Codes: A61M 2230/42 : Rate
• CPC Class Codes: A61M 5/20 : Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/2053 : Media being expelled from injector by pressurised fluid or vacuum for infusion A61M5/145, A61M5/155
• CPC Class Codes: A61M 5/31 : Details
• CPC Class Codes: A61M 5/3157 : Means providing feedback signals when administration is completed A61M5/20 takes precedence
• CPC Class Codes: A61M 5/3202 : Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/5086 : for indicating if defective, used, tampered with or unsterile
• CPC Class Codes: G08B 21/185 : Electrical failure alarms
• CPC Class Codes: G09B 9/00 : Simulators for teaching or training purposes for the use of weapons F41; computing aspects G06; protocols for games, networked simulations or virtual reality H04L67/131
• CPC Class Codes: G16H 20/17 : delivered via infusion or injection
• CPC Class Codes: H04B 1/3827 : Portable transceivers
• CPC Class Codes: H04W 4/80 : Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

In some embodiments, a method includes establishing a communications link between a computing device and an adapter. The adapter is configured to receive at least a portion of a medicament delivery device. A wireless signal is received to maintain the communications link. A relative position between the computing device and the adapter is determined. An alarm is produced when the wireless signal is not received within a time period. The alarm is based on the relative position between the computing device and the adapter.

Claims

1. A method, comprising:

establishing a communications link, via a short-range wireless protocol, between a computing device and a medicament delivery device, the medicament delivery device including an electronic circuit system, the electronic circuit system including a radio;

receiving a first wireless signal from the radio to maintain the communications link, the first wireless signal being periodic;

producing a first alarm when the first wireless signal is not received within a time period, the first alarm indicating that the computing device is out of a communication range of the medicament delivery device;

receiving a user input from a user in response to a location prompt;

transmitting to the radio a second wireless signal, the second wireless signal including instructions that, when received by the radio, cause the electronic circuit system to produce a second alarm, the second alarm including at least one of an audible output or a visual output; and

producing, via the computing device, a direction output to direct the user to a location of the medicament delivery device.

2. The method of claim 1, wherein the medicament delivery device is any one of an auto-injector, a nasal delivery device or an inhaler.

3. The method of claim 1, further comprising:

determining, based at least in part on the first wireless signal, the location of the medicament delivery device; and

producing, via the computing device, a location alert indicating the location.

4. The method of claim 1, further comprising:

receiving a third wireless signal from the radio, the third wireless signal associated with a temperature of the medicament delivery device; and

producing a third alarm in response to the third wireless signal, the third alarm indicating that the temperature is outside of a temperature range.

5. The method of claim 1, wherein the medicament delivery device is an auto-injector configured to deliver at least one of a dose of epinephrine, a dose of naloxone, or a dose of glucagon.

6. The method of claim 1, wherein the medicament delivery device includes a case configured to contain at least a portion of an inner housing and an actuator of the medicament delivery device, the inner housing and the actuator configured to be removed from the case prior to actuation of the medicament delivery device, the electronic circuit system coupled to the case.

7. The method of claim 6, further comprising:

receiving a third wireless signal from the radio, the third wireless signal associated with removal of the inner housing and the actuator from the case;

producing, via at least one of the computing device or the electronic circuit system, a third alarm indicating that the medicament delivery device is in use.

8. The method of claim 7, wherein the producing the third alarm includes producing an emergency prompt via a screen of the computing device, the emergency prompt associated with any one of an emergency phone number or an emergency contact.

9. The method of claim 8, wherein the user input is a first user input, the method further comprising:

receiving, in response to the emergency prompt, a second user input; and

transmitting from the computing device and in response to the second user input a notification to be received by an emergency personnel.

10. The method of claim 1, wherein:

the electronic circuit system includes a global positioning sensor (GPS) component; and

the direction output is based on operation of the GPS component.

11. The method of claim 1, wherein the producing the direction output is based on a global positioning sensor satellite positioning output.

12. The method of claim 1, wherein the user input is a first user input and the computing device includes a touchscreen, the method further comprising:

producing, via the touchscreen, an instruction prompt associated with a use instruction of the medicament delivery device;

receiving, in response to the instruction prompt, a second user input; and

transmitting, in response to the second user input and via the touchscreen, the use instruction.

13. A method, comprising:

establishing a communications link, via a short-range wireless protocol, between a computing device and a medicament delivery kit, the medicament delivery kit including a medicament delivery device, a case, and an electronic circuit system, the case configured to receive at least a portion of the medicament delivery device, the electronic circuit system coupled to the case and including a radio;

receiving a first wireless signal from the radio to maintain the communications link, the first wireless signal being periodic;

producing a first alarm when the first wireless signal is not received within a time period, the first alarm indicating that the computing device is out of a communication range of the case;

receiving a first user input from a user in response to a location prompt;

transmitting to the radio a second wireless signal, the second wireless signal including instructions that, when received by the radio, cause the electronic circuit system to produce a second alarm, the second alarm including at least one of an audible output or a visual output;

producing, via the computing device, a direction output to direct the user to a location of the case;

producing, via the computing device, an instruction prompt associated with a use instruction of the medicament delivery device;

receiving, in response to the instruction prompt, a second user input; and

transmitting, in response to the second user input and via the computing device, the use instruction.

14. The method of claim 13, wherein:

the computing device includes a touchscreen; and

the transmitting includes transmitting the use instruction via the touchscreen.

15. The method of claim 13, further comprising:

determining the location of the case; and

producing, via the computing device, a location alert indicating the location.

16. The method of claim 15, further comprising:

producing, via the computing device, a direction output to direct the user to a location of the medicament delivery device.

17. The method of claim 16, wherein the producing the direction output is based on a global positioning sensor satellite positioning output.

18. The method of claim 13, further comprising:

receiving a third wireless signal from the radio, the third wireless signal associated with removal of the medicament delivery device from the case;

producing, via at least one of the computing device or the electronic circuit system, a third alarm indicating that the medicament delivery device is in use.

19. The method of claim 18, wherein the producing the third alarm includes producing an emergency prompt via a screen of the computing device, the emergency prompt associated with any one of an emergency phone number or an emergency contact.

20. The method of claim 13, wherein the medicament delivery device is an auto-injector configured to deliver at least one of a dose of epinephrine, a dose of naloxone, or a dose of glucagon.