Injection device

• US 10,232,129 B2
• Filed: 12/02/2009
• Issued: 03/19/2019
• Est. Priority Date: 12/02/2008
• Status: Active Grant

• Current Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Original Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Inventors: Tezel, Ahmet, McNerney, Kevin, Mudd, Christopher S., Storie, Blake R., Mandaroux, Bastien
• Primary Examiner(s): Eisenberg, Rebecca E
• Assistant Examiner(s): Lee, Weng
• Application Number:
  US12/629,480
• Publication Number:
  US 20100152679A1
• Time in Patent Office: 3,394 Days
• Field of Search: 604240-241
• CPC Class Codes: A61M 2210/04 Skin
• CPC Class Codes: A61M 5/3293 characterised by features of the needle hub
• CPC Class Codes: A61M 5/347 rotatable, e.g. bayonet or screw A61M5/344 takes precedence

Abstract

An injection device includes a syringe having a body with a piston disposed therein with an open end along with a viscous fluid disposed in the body for injection by the piston. A needle assembly is provided which includes a cannula having a luer connection engageable with the syringe distal end with the luer connector including a hub. Mating engagement is provided by way of internal threads at the syringe distal end and external threads of a hub with a pitch sufficient to prevent detachment of the hub from the syringe distal end during ejection of the viscous fluid. In addition, a stepped cavity, disposed in the hub, further prevents detachment of the hub from the syringe distal end during ejection of the viscous fluid.

Claims

1. An injection device for delivering a dermal filler, the device comprising:

a syringe having (i) a body with a piston disposed therein and (ii) an open distal end portion including a tapered syringe cone;

a needle assembly comprising a cannula and a luer connector engageable with the syringe open distal end portion, said luer connector comprising a hub having an inner bore, the inner bore comprising a proximal retention section, a stepped section, and a cannula retention section, the proximal retention section being mateable with the syringe open distal end portion, the stepped section being smaller in diameter than the proximal retention section and being disposed intermediate the proximal retention section and the cannula retention section, the inner bore having a stepped section surface wherealong the inner bore decreases in diameter to a proximal end of a cannula retention surface of the cannula retention section, the inner bore not increasing in diameter from the proximal retention section to a distal end of the cannula retention section, the cannula retention section having a constant diameter, the cannula retention surface being mated against an outer surface of the cannula to secure the cannula within the cannula retention section; and

internal threads disposed in the syringe open distal end portion and external threads disposed on said hub enabling mating engagement between the hub and the syringe open distal end portion;

said hub having an inside surface of the proximal retention section comprising a wall correspondingly tapered to said tapered syringe cone and that includes a step extending normal to the wall, the step being spaced apart from a distal-most surface of the tapered syringe cone in a distal direction when the hub and the syringe cone are maximally seated thereby reducing dead space within the proximal retention section for preventing detachment of the hub from the tapered syringe cone during injection of a dermal filler contained in the syringe body.

2. The device according to claim 1, wherein the internal threads have a pitch of between about 2 mm and about 5 mm.

3. The device according to claim 2, wherein the internal threads have a pitch of about 3 mm.

4. The device according to claim 3, wherein the external threads comprise double lead screw threads.

5. The device according to claim 1, wherein the external threads comprise single circumference double lead screw threads.

6. The device according to claim 1, further comprising a hyaluronic acid-based dermal filler contained in the syringe body and wherein the dermal filler has a viscosity of at least about 130,000 cps.

7. The device of claim 1, wherein the cannula has a gauge of greater than about 25 G.

8. The device of claim 1, wherein the cannula has a gauge between 21 G and 32 G.

9. The device of claim 1, wherein the hub comprises polycarbonate and the syringe internal threads have a pitch of about 3 mm, and wherein when the hub is threadingly coupled to the syringe at a torque of 0.07 Nm, a detachment force of the hub from the syringe exceeds 200 Newtons.

10. The device of claim 1, wherein the cannula retention surface extends normal to the stepped section surface.

11. The device of claim 1, wherein the cannula retention surface extends continuously with the stepped section surface.

12. The device of claim 1, wherein the outer surface of the cannula is mated against the cannula retention surface from the proximal end of the cannula retention surface to the distal end of the hub.

13. The device of claim 1, wherein the stepped section has a constant diameter.

14. A needle assembly for an injection device for facilitating delivery of a dermal filler, the assembly comprising:

a needle hub comprising an inner bore and a longitudinal axis, the inner bore having a proximal retention section, an intermediate section, and a cannula retention section, the proximal retention section having a tapered inner surface and a proximal step whereat the inner bore decreases in diameter to the intermediate section, the proximal step being formed by an intersection of a wall surface of the proximal retention section and an inner surface of the intermediate section, the wall surface of the proximal retention section extending perpendicular relative to the longitudinal axis, the intermediate section having a cannula step whereat the inner bore decreases in diameter to a proximal end of the cannula retention section, the proximal step being interposed between the tapered inner surface and the cannula step, the inner bore not increasing in diameter from the proximal retention section to a distal end of the cannula retention section, the cannula retention section having a constant diameter, the cannula step being formed by an intersection of a wall surface of the intermediate section and a cannula engagement surface of the cannula retention section; and

a cannula having a proximal portion seated against the cannula retention section;

wherein the proximal retention section and the intermediate section, when coupled with a distal end portion of a syringe, collectively reduce dead space within the inner bore for preventing detachment of the hub from the syringe during an injection procedure.

15. The needle assembly of claim 14, further comprising a syringe having a distal end portion.

16. The needle assembly of claim 14, wherein the hub further comprises a luer connector engageable with a distal end portion of a syringe.

17. The needle assembly of claim 14, further comprising external threads disposed on the hub enabling mating engagement between the hub and internal threads of a distal end portion of a syringe.

18. The needle assembly of claim 17, wherein the external threads comprise double lead screw threads.

19. The needle assembly of claim 17, wherein the external threads comprise single circumference double lead screw threads.

20. The needle assembly of claim 14, wherein the hub comprises polycarbonate, and further comprising a syringe having internal threads that have a pitch of about 3 mm, and wherein when the hub is threadingly coupled to the syringe at a torque of 0.07 Nm, a detachment force of the hub from the syringe exceeds 200 Newtons.

21. The needle assembly of claim 14, wherein the cannula engagement surface extends normal to the intermediate section wall.

22. The needle assembly of claim 14, wherein the cannula retention surface extends continuously with the intermediate section wall.

23. The needle assembly of claim 14, wherein the proximal portion of the cannula is mated against the cannula retention surface from the proximal end of the cannula retention section to the distal end of the hub.

24. The needle assembly of claim 14, wherein the intermediate section has a constant diameter.

25. The needle assembly of claim 14, wherein the proximal retention section has a tapered diameter.

26. A needle assembly for an injection device for facilitating delivery of a dermal filler, the assembly consisting essentially of:

a needle hub comprising an inner bore and a longitudinal axis, the inner bore having a proximal retention section, an intermediate section, and a cannula retention section, the proximal retention section having a tapered inner surface and a proximal step whereat the inner bore decreases in diameter to the intermediate section, the proximal step being formed by an intersection of a wall surface of the proximal retention section and an inner surface of the intermediate section, the wall surface of the proximal retention section extending perpendicular relative to the longitudinal axis, the intermediate section having a cannula step whereat the inner bore decreases in diameter to a proximal end of the cannula retention section, the proximal step being interposed between the tapered inner surface and the cannula step, the inner bore not increasing in diameter from the proximal retention section to a distal end of the cannula retention section, the cannula retention section having a constant diameter, the cannula step being formed by an intersection of a wall surface of the intermediate section and a cannula engagement surface of the cannula retention section; and

a cannula having a proximal portion seated against the cannula retention section;

wherein the proximal retention section and the intermediate section, when coupled with a distal end portion of a syringe, collectively reduce dead space within the inner bore for preventing detachment of the hub from the syringe during an injection procedure.