Electroporation with cooling to treat tissue
First Claim
1. A method of treating tissue with electrical energy, the method comprising:
- performing electroporation of target tissue using one or more electroporation devices comprising one or more electrodes and one or more hollow chambers with a fluid disposed therein; and
flowing the fluid disposed in one or more of the hollow chambers to provide cooling during the electroporation to cause non-thermal cell death of the target tissue.
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Accused Products
Abstract
The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
797 Citations
19 Claims
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1. A method of treating tissue with electrical energy, the method comprising:
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performing electroporation of target tissue using one or more electroporation devices comprising one or more electrodes and one or more hollow chambers with a fluid disposed therein; and flowing the fluid disposed in one or more of the hollow chambers to provide cooling during the electroporation to cause non-thermal cell death of the target tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of treating tissue with electrical energy, the method comprising:
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delivering electrical energy to target tissue to cause non-thermal irreversible electroporation (IRE) of cells using one or more electroporation devices comprising one or more electrodes and one or more hollow chambers with a fluid disposed therein; and flowing the fluid disposed in one or more of the hollow chambers to provide for cooling at an electrode-tissue interface. - View Dependent Claims (9, 10, 11, 12)
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13. A method of treating tissue with electrical energy, the method comprising:
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delivering electrical energy to target tissue using one or more electroporation devices comprising; at least two electrodes disposed as annular conductive surfaces along an axis of a single probe; and one or more hollow chambers with a fluid disposed therein; wherein the delivering of the electrical energy to the target tissue comprises alternating polarity of the at least two electrodes; flowing the fluid disposed in one or more of the hollow chambers to provide for cooling during the delivering to result in non-thermal cell death within the target tissue. - View Dependent Claims (14, 15, 16, 17, 18, 19)
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Specification