Immunogenic composition

  • US 10,245,317 B2
  • Filed: 09/14/2016
  • Issued: 04/02/2019
  • Est. Priority Date: 06/27/2005
  • Status: Active Grant
First Claim
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1. An immunogenic composition, comprising:

  • (a) a Neisseria meningitidis (N. meningitides) serogroup A capsular saccharide conjugated to an adipic acid dihydrazide (ADH) linker, wherein the linker is conjugated to tetanus toxoid carrier protein;

    (b) a N. meningitidis serogroup C capsular saccharide conjugated to an adipic acid dihydrazide (ADH) linker, wherein the linker is conjugated to tetanus toxoid carrier protein;

    (c) a N. meningitidis serogroup W capsular saccharide directly conjugated to tetanus toxoid carrier protein in the absence of a linker; and

    (d) a N. meningitidis serogroup Y capsular saccharide directly conjugated to tetanus toxoid carrier protein in the absence of a linker;

    wherein the ratio of Men A saccharide to carrier protein is between 1;

    2 to 1;

    5 (w/w); and

    wherein the ratio of MenC saccharide to carrier protein is between 1;

    2 to 1;

    5 (w/w).

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