Safety apparatus for extracorporeal blood treatment

• US 10,245,364 B2
• Filed: 04/15/2013
• Issued: 04/02/2019
• Est. Priority Date: 04/16/2012
• Status: Active Grant

• Current Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius Medical Care AG)
• Original Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius Medical Care AG)
• Inventors: Brandl, Martin, Falkenhagen, Dieter, Hartmann, Jens
• Primary Examiner(s): Drodge, Joseph W
• Application Number:
  US14/394,949
• Publication Number:
  US 20150122712A1
• Time in Patent Office: 2,178 Days
• Field of Search: 210646, 210647, 210 962, 604 401, 604 501, 604 601, 604 29, 604 65, 604 67
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1603 Regulation parameters
• CPC Class Codes: A61M 1/1609 after use, i.e. downstream of dialyser
• CPC Class Codes: A61M 1/361 before treatment
• CPC Class Codes: A61M 1/3612 after treatment
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3672 Means preventing coagulation
• CPC Class Codes: A61M 1/3675 Deactivation
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/3324 PH measuring means
• CPC Class Codes: A61M 2230/202 partial carbon oxide pressure, e.g. partial dioxide pressure (P-CO2)
• CPC Class Codes: A61M 2230/208 pH-value
• CPC Class Codes: B01D 61/30 Accessories; Auxiliary operation
• CPC Class Codes: B01D 61/32 Controlling or regulating
• CPC Class Codes: F04C 2270/0421 Controlled or regulated

Abstract

Blood purification device having an extracorporeal blood circuit with a blood inflow and outflow to and from a dialysis unit, wherein the dialysis unit comprises a dialysis solution inflow and a dialysate outflow, characterized by a control loop for control of the acid-base equilibrium of the blood, wherein bicarbonate is supplied to the blood using an aqueous bicarbonate-containing solution, wherein a measuring means for measuring a blood buffer parameter is associated with the control loop, wherein the blood buffer parameter is selected from one of bicarbonate concentration and CO₂ partial pressure, and wherein a signal corresponding to the measured value of the blood buffer parameter can be supplied to a closed-loop control apparatus, which regulates the value of the blood buffer parameter by the supply of bicarbonate, and at least one pH-measuring means, wherein a signal corresponding to the pH value can be supplied to an alarm apparatus.

Claims

1. A blood purification device comprising:

an extracorporeal blood circuit with a blood inflow to a dialysis unit for blood removed from a patient and a blood outflow from the dialysis unit for blood being guided back into the patient, wherein the dialysis unit comprises an inflow for a dialysis solution and a dialysate outflow,

a citrate anticoagulation apparatus, wherein citrate is supplied to the extracorporeal blood circuit at a citrate supply point upstream of the dialysis unit and a substitute medium dosing apparatus, wherein substitution medium is supplied at a substitution medium supply point downstream of the dialysis unit,

a control loop for controlling the acid-base balance of the blood, wherein bicarbonate is supplied to the blood by means of an aqueous bicarbonate-containing solution, wherein at least one measuring means for measuring a blood buffer parameter is associated with the control loop and upstream of the citrate supply point in the extracorporeal blood circuit, wherein the blood buffer parameter is selected from the group consisting of bicarbonate concentration and CO₂ partial pressure, and wherein a signal corresponding to the measured actual value of the blood buffer parameter can be supplied to a control apparatus, which regulates the actual value of the blood buffer parameter via the supply of bicarbonate to a predeterminable intended value or intended value range,

at least one pH-measuring means, which is arranged upstream of the citrate supply point in the extracorporeal blood circuit, wherein a signal corresponding to the pH value can be supplied to an alarm apparatus, which triggers an alarm signal if a predeterminable pH value or a pH-value range is exceeded or undershot,

wherein the arrangement of the at least one measuring means for measuring a blood buffer parameter located upstream of the citrate supply point in the extracorporeal blood circuit and the at least one pH-measuring arranged upstream of the citrate supply point are configured to detect and prevent or treat disturbances of the acid-base balance during an extracorporeal blood purification selected from the group of compensated acidosis, non-compensated acidosis, compensated alkalosis and compensated or non-compensated alkalosis,

at least one additional measuring means for measuring a blood buffer parameter that is associated with the control loop and arranged downstream of the dialysis unit and upstream of the substitution medium supply point in the extracorporeal blood circuit, and

at least one additional pH-measuring means that is arranged downstream of the substitution medium supply point in the extracorporeal blood circuit, wherein a signal corresponding to the pH value can be supplied to the alarm apparatus, which triggers an alarm signal if a predeterminable pH value or pH-value range is exceeded or undershot.

2. The blood purification device according to claim 1, wherein the aqueous bicarbonate-containing solution is a dialysis solution.

3. The blood purification device according to claim 1, wherein the aqueous bicarbonate-containing solution is an infusion solution.

4. The blood purification device according to claim 1, wherein at least one additional measuring means for measuring a blood buffer parameter is comprised within the control loop and is arranged upstream of the dialysis unit in the extracorporeal blood circuit.

5. The blood purification device according to claim 1, wherein at least one additional measuring means for measuring a blood buffer parameter is comprised within the control loop and is arranged upstream of the citrate supply point in the extracorporeal blood circuit.

6. The blood purification device according to claim 1, wherein at least one additional measuring means for measuring a blood buffer parameter is associated with the control loop and is arranged in the dialysate outflow.