Stable liquid formulation of etanercept

  • US 10,258,689 B2
  • Filed: 06/01/2012
  • Issued: 04/16/2019
  • Est. Priority Date: 06/03/2011
  • Status: Active Grant
First Claim
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1. A liquid formulation of etanercept, consisting of 1 to 100 mg/mL of etanercept, 0.1 to 250 mM of methionine or pharmaceutically acceptable salts thereof as a stabilizer, 0.1 to 100 mM of phosphate buffer, and 1 to 1000 mM of sodium chloride;

  • wherein the liquid formulation has an increased storage stability of etanercept compared to the formulation comprising arginine as a stabilizer, by reducing etanercept by products that are produced due to denaturation during storage.

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