High-purity quinoline derivative and method for manufacturing same

• US 10,259,791 B2
• Filed: 08/26/2015
• Issued: 04/16/2019
• Est. Priority Date: 08/28/2014
• Status: Active Grant

• Current Assignee: Eisai R & D Management Company Limited (Eisai Medical Research Incorporated)
• Original Assignee: Eisai R & D Management Company Limited (Eisai Medical Research Incorporated)
• Inventors: Nakamura, Taiju, Abe, Taichi, Miyashita, Yusuke, Kuroda, Hirofumi, Ayata, Yusuke, Akao, Atsushi
• Primary Examiner(s): Seaman, D Margaret M
• Application Number:
  US15/503,108
• Publication Number:
  US 20170233344A1
• Time in Patent Office: 1,329 Days
• CPC Class Codes: A61K 31/47 Quinolines; Isoquinolines
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07D 215/48 Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

Provided is a compound represented by formula (IV) or a salt thereof, wherein the content of the compound represented by formula (I) is 350 ppm by mass or less.

Claims

1. A methanesulfonate salt of a compound represented by formula (IV), wherein the content of a compound represented by formula (A-1) is 60 ppm by mass or less

2. The methanesulfonate salt of a compound represented by formula (IV) according to claim 1, wherein the content of a compound represented by formula (I) is 183 ppm by mass or less, and the content of a compound represented by formula (A-1) is 60 ppm by mass or less

10. The methanesulfonate salt of a compound represented by formula (IV) according to claim 2, wherein the content of the methanesulfonate salt of a compound represented by formula (IV) is 98.0% by mass or more

12. The methanesulfonate salt of a compound represented by formula (IV) according to claim 2, wherein the content of the compound represented by formula (I) and the content of the compound represented by formula (A-1) are measured by HPLC.

3. A method for producing a compound represented by formula (IV)

4. The method according to claim 3, comprising:

a step A of, after allowing a compound represented by formula (A-1)

5. The method according to claim 3, further comprising a step D of converting the compound represented by formula (IV) obtained in the step C into a salt of the compound represented by formula (IV).

6. The method according to claim 5, wherein the salt obtained in the step D is a methanesulfonate.

7. The method according to claim 3, wherein the step B is a step of allowing the compound represented by formula (I)

8. The method according to claim 3, wherein the compound represented by formula (II-A) is phenyl chloroformate.

9. The methanesulfonate salt of a compound represented by formula (IV) according to claim 3, wherein the content of the methanesulfonate salt of a compound represented by formula (IV) is 98.0% by mass or more

11. The methanesulfonate salt of a compound represented by formula (IV) according to claim 3, wherein the content of the compound represented by formula (A-1) is determined by HPLC.