Systems and methods for electrical stimulation-related patient population volume analysis and use
First Claim
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1. A computer-implemented method, comprising:
- obtaining user input of a clinical effect, wherein the clinical effect is either a therapeutic effect or a side effect;
obtaining a plurality of estimated volumes of activation (VOA) associated with electrical stimulations of a patient population, wherein a first group of the VOAs is associated with the clinical effect and a second group of the VOAs is not associated with the clinical effect;
based on the VOAs, determining a target stimulation region when the clinical effect is the therapeutic effect or determining a side effect region when the clinical effect is the side effect, wherein either determining comprises determining, on a voxel-by-voxel basis, that a voxel is in the target stimulation region or side effect region when the voxel is included in statistically significantly more of the VOAs of the first group of VOAs than in the VOAs of the second group of VOAs; and
outputting the determined target stimulation region or side effect region.
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Abstract
A computer implemented system and method facilitates a cycle of generation, sharing, and refinement of volumes related to stimulation of anatomical tissue, such as brain or spinal cord stimulation. Such volumes can include target stimulation volumes, side effect volumes, and volumes of estimated activation. A computer system and method also facilitates analysis of groups of volumes, including analysis of differences and/or commonalities between different groups of volumes.
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20 Claims
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1. A computer-implemented method, comprising:
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obtaining user input of a clinical effect, wherein the clinical effect is either a therapeutic effect or a side effect; obtaining a plurality of estimated volumes of activation (VOA) associated with electrical stimulations of a patient population, wherein a first group of the VOAs is associated with the clinical effect and a second group of the VOAs is not associated with the clinical effect; based on the VOAs, determining a target stimulation region when the clinical effect is the therapeutic effect or determining a side effect region when the clinical effect is the side effect, wherein either determining comprises determining, on a voxel-by-voxel basis, that a voxel is in the target stimulation region or side effect region when the voxel is included in statistically significantly more of the VOAs of the first group of VOAs than in the VOAs of the second group of VOAs; and outputting the determined target stimulation region or side effect region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification