Device for drug delivery

• US 10,272,199 B2
• Filed: 09/18/2015
• Issued: 04/30/2019
• Est. Priority Date: 07/02/2007
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Inventors: Yodfat, Ofer, Shapira, Gali
• Primary Examiner(s): Gilbert, Andrew M
• Application Number:
  US14/857,991
• Publication Number:
  US 20160001002A1
• Time in Patent Office: 1,320 Days
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 5/1408 in parallel, e.g. manifolds, sequencing valves access sites A61M39/02; tube connectors A61M39/10
• CPC Class Codes: A61M 5/14228 with linear peristaltic action, i.e. comprising at least three pressurising members or a helical member
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

Delivery of more than one therapeutic fluid as a means to control symptoms of a health conditions is disclosed. More than one therapeutic fluid may be dispensed from more than one reservoir and delivered to a user'"'"'s body via one or more cannula that penetrate the skin. The therapeutic fluids may be delivered by action of one or more pumping mechanisms that may be controlled by a processor in a portable, ambulatory device. The therapeutic fluids may optionally be insulin and one or more of an amylin analog, pramlintide acetate and an exenatide, and the health condition may optionally be diabetes. This device can be used in combination with a glucometer.

Claims

1. A portable therapeutic fluid delivery device having a form factor that permits ambulatory use by a user, the device comprising:

a first reservoir for containing a first therapeutic fluid;

a second reservoir for containing a second therapeutic fluid;

at least one cannula in fluid communication with the first and/or second reservoir, the at least one cannula being disposed to penetrate the user'"'"'s skin to deliver the first and/or the second therapeutic fluid subcutaneously at a dosing rate;

at least one pumping mechanism that delivers the first therapeutic fluid from the first reservoir at a first dosing rate and delivers the second therapeutic fluid from the second reservoir at a second dosing rate to the at least one cannula and into the user;

a processor that controls the at least one pumping mechanism;

a disposable part; and

a reusable part configured to mate with the disposable part to form a dispensing patch unit, wherein the disposable part comprises a housing that contains the at least one cannula, the first reservoir, the second reservoir and a fluid delivery path between the cannula and at least one of the first and second reservoirs, wherein the cannula extends directly from the housing, and the reusable part comprises the processor and the at least one pumping mechanism.

2. The portable therapeutic fluid delivery device as in claim 1, wherein the at least one cannula comprises a first cannula in fluid communication with the first reservoir and a second cannula in fluid communication with the second reservoir.

3. The portable therapeutic fluid delivery device as in claim 1, wherein the first dosing rate is different from the second dosing rate.

4. The portable therapeutic fluid delivery device as in claim 1, wherein the at least one pumping mechanism comprises a first pumping mechanism and a second pumping mechanism, the first pumping mechanism delivering the first fluid from the first reservoir and the second pumping mechanism delivering the second fluid from the second reservoir.

5. The portable therapeutic fluid delivery device as in claim 1, wherein the first therapeutic fluid is insulin, and the first dosing rate comprises a basal dosing component and/or a bolus component.

6. The portable therapeutic fluid delivery device as in claim 1, wherein the second therapeutic fluid is an amylin analog.

7. The portable therapeutic fluid delivery device as in claim 6, wherein the amylin analog comprises pramlintide acetate.

8. The portable therapeutic fluid delivery device as in claim 1, wherein the second therapeutic fluid is a glucagon.

9. The portable therapeutic fluid delivery device as in claim 1, wherein the second therapeutic fluid is an exenatide.

10. The portable therapeutic fluid delivery device as in claim 6, wherein the first and/or second dosing rate is based on expected calorie and/or carbohydrate intake by the user.

11. The portable therapeutic fluid delivery device as in claim 1, wherein the at least one pumping mechanism comprises a peristaltic pumping mechanism.

12. The portable therapeutic fluid delivery device as in claim 1, wherein the first reservoir and the second reservoir are coupled to a single housing.

13. The portable therapeutic fluid delivery device as in claim 1, further comprising one or more buttons via which the user can adjust the first and/or the second dosing rate.