Implantable estrus detection devices, systems, and methods

• US 10,278,675 B2
• Filed: 07/31/2014
• Issued: 05/07/2019
• Est. Priority Date: 07/31/2014
• Status: Active Grant

• Current Assignee: Xerox Corporation (Xerox Holdings Corp.)
• Original Assignee: Palo Alto Research Center, Inc. (Xerox Holdings Corp.)
• Inventors: Johnson, David Mathew, Uhland, Scott A., Abhishek, Ramkumar, Krivacic, Robert Thomas, Sheridan, Martin
• Primary Examiner(s): Abouelela, May A
• Application Number:
  US14/448,074
• Publication Number:
  US 20160030010A1
• Time in Patent Office: 1,741 Days
• Field of Search: 600300, 600301, 600551, 607 28
• CPC Class Codes: A01K 29/005 Monitoring or measuring activity, e.g. detecting heat or mating
• CPC Class Codes: A61B 10/0012 Ovulation-period determination for animals A61D17/002
• CPC Class Codes: A61B 2010/0016 based on measurement of electric currents, e.g. conductivity tests
• CPC Class Codes: A61B 2010/0019 based on measurement of temperature
• CPC Class Codes: A61B 2503/40 Animals
• CPC Class Codes: A61B 5/02055 Simultaneously evaluating both cardiovascular condition and temperature
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/035 Intra-uterine probes therefor
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/1032 Determining colour for diagnostic purposes measuring colour in general G01J3/46
• CPC Class Codes: A61B 5/1118 Determining activity level
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61D 17/002 for detecting period of heat of animals, i.e. for detecting oestrus for humans A61B10/0012
• CPC Class Codes: A61D 19/027 Devices for injecting semen into animals, e.g. syringes, guns, probes
• CPC Class Codes: A61D 19/04 for embryo transplantation

Abstract

Devices, systems, and methods for detecting estrus in subjects are provided. Devices include a housing configured for intravaginal/intrauterine deployment and retention and a sensor disposed in or on the housing, and are configured to use condition information sensed by the sensor to determine an estrus condition of the subject. Methods include deploying a device in the subject, sensing the condition information, and determining an estrus condition using the condition information. Systems include a device configured to communicate with a base station and/or with other implanted devices, which are located within a reception radius thereof, regarding the determined estrus condition.

Claims

1. A method of detecting an estrus condition of a subject, comprising:

programming an estrus detection device configured for intravaginal or intrauterine retention with biometric information about the subject;

deploying the device in the subject;

calculating a predetermined threshold of estrus conditions for insemination by the device using the biometric information;

sensing, via at least one sensor of the device, condition information of the subject; and

determining an estrus condition of the subject using the condition information.

2. The method of claim 1, further comprising:

programming the device with identification information about the subject.

3. The method of claim 1, wherein the at least one sensor is selected from temperature sensors, conductivity sensors, color sensors, pulse sensors, activity sensors, mounting sensors, and pressure sensors.

4. The method of claim 1, wherein:

the sensing comprises sensing, via at least two sensors, condition information of the subject, and

the at least two sensors are selected from temperature sensors, conductivity sensors, color sensors, pulse sensors, activity sensors, mounting sensors, and pressure sensors.

5. The method of claim 1, further comprising:

dispensing a fluid when the estrus condition of the subject meets the predetermined threshold,

wherein the fluid is selected from drugs, semen, ova, and combinations thereof.

6. The method of claim 5, further comprising:

calculating the predetermined threshold based on at least one of real time crowd data, historic data, and modeling algorithms.

7. The method of claim 5, further comprising:

receiving real time crowd data from one or more other implanted estrus detection devices, a base station, or both, which is located within a reception radius of the device; and

wherein calculating the predetermined threshold includes calculating the predetermined threshold based on the real time crowd data and comprises adjusting an expected threshold for an estrus condition based on the real time crowd data for that estrus condition to determine the predetermined threshold for an estrus condition.

8. The method of claim 1, further comprising transmitting the determined estrus condition of the subject to another implanted estrus detection device, a base station, or both.

9. A system for detecting an estrus condition of a subject, comprising:

at least one implantable estrus detection device programmed with biometric information about the subject and configured for intravaginal or intrauterine deployment and retention in a subject and configured to calculate an expected estrus condition threshold value, the device comprising at least one sensor configured to detect condition information of the subject, and determine an estrus condition of the subject using the condition information of the subject,

wherein the at least one implantable estrus detection device is configured to communicate with a base station, other implanted estrus detection devices, or both, which are located within a reception radius thereof, regarding the determined estrus condition, and

wherein the at least one implantable estrus detection device is configured to collect condition information from other implantable estrus detection devices within a reception radius thereof, and to transmit the collected condition information to the base station when it comes within a reception radius thereof.

10. The system of claim 9, wherein:

the system comprises at least two of the implantable estrus detection devices.

11. An implantable estrus detection device, comprising:

a housing configured for intravaginal or intrauterine deployment and retention in a subject;

at least one sensor disposed in or on the housing; and

a fluid delivery mechanism configured to dispense a fluid when an estrus condition is detected in the subject and determined to meet a predetermined threshold,

wherein the device is configured to use condition information sensed by the at least one sensor to determine an estrus condition of the subject, and

wherein the device is configured to calculate the predetermined threshold based, at least in part, on biometric subject data.

12. The device of claim 11, wherein the at least one sensor is selected from temperature sensors, conductivity sensors, color sensors, pulse sensors, activity sensors, mounting sensors, and pressure sensors.

13. The device of claim 11, wherein the device comprises at least two sensors and is configured to use condition information sensed by the at least two sensors to determine an estrus condition of the subject, the sensors being selected from temperature sensors, conductivity sensors, color sensors, pulse sensors, activity sensors, mounting sensors, and pressure sensors.

14. The device of claim 11, further comprising at least one port via which the at least one sensor is in communication with surrounding vaginal or uterine tissue or fluid.

15. The device of claim 11, wherein the fluid is selected from drugs, semen, ova, and combinations thereof.

16. The device of claim 15, wherein the device is configured to calculate the predetermined threshold based on at least one of real time crowd data, historic data, and modeling algorithms.

17. The device of claim 11, further comprising an antenna configured to transmit information to and/or receive information from other implantable estrus detection devices, a base station, or both.

18. The device of claim 17, wherein the antenna comprises an external device retrieval member.