Electrical ablation devices and methods

• US 10,278,761 B2
• Filed: 01/14/2016
• Issued: 05/07/2019
• Est. Priority Date: 02/28/2011
• Status: Active Grant

• Current Assignee: Cilag Gmbh International (Johnson & Johnson)
• Original Assignee: Ethicon, LLC (Johnson & Johnson)
• Inventors: Long, Gary L., Plescia, David N., Bakos, Gregory J.
• Primary Examiner(s): Peffley, Michael
• Assistant Examiner(s): Zink, Amanda
• Application Number:
  US14/995,728
• Publication Number:
  US 20160128759A1
• Time in Patent Office: 1,209 Days
• CPC Class Codes: A61B 18/12 by passing a current through the tissue to be heated, e.g. high-frequency current
• CPC Class Codes: A61B 18/1477 Needle-like probes
• CPC Class Codes: A61B 2017/0088 ceramic
• CPC Class Codes: A61B 2018/00333 Breast
• CPC Class Codes: A61B 2018/00446 Brain
• CPC Class Codes: A61B 2018/00488 Esophagus
• CPC Class Codes: A61B 2018/00494 Stomach, intestines or bowel
• CPC Class Codes: A61B 2018/005 Rectum
• CPC Class Codes: A61B 2018/00535 Biliary tract
• CPC Class Codes: A61B 2018/00541 Lung or bronchi
• CPC Class Codes: A61B 2018/00547 Prostate
• CPC Class Codes: A61B 2018/00559 Female reproductive organs
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00613 Irreversible electroporation reversible electroporation A61N1/327
• CPC Class Codes: A61B 2018/00982 combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes
• CPC Class Codes: A61B 2034/2063 Acoustic tracking systems, e.g. using ultrasound
• CPC Class Codes: A61B 2090/065 for measuring contact or contact pressure
• CPC Class Codes: A61B 2090/08021 of the patient or his organs
• CPC Class Codes: A61B 34/76 Manipulators having means for providing feel, e.g. force or tactile feedback
• CPC Class Codes: A61N 1/327 for enhancing the absorption properties of tissue, e.g. by electroporation

Abstract

An ablation device may generally comprise a first electrode, a plurality of second electrodes, and a grounding pad. Each of the plurality of second electrodes may comprise a first conductive section, a second conductive section, and a non-conductive section between the first conductive section and the second conductive section. The first electrode and each of the plurality of second electrodes may be coupled to an energy source delivering a series of electrical pulses to tissue to induce cell necrosis by irreversible electroporation.

Claims

1. An ablation apparatus, comprising:

a first electrode having a first diameter;

a plurality of second electrodes, each of the plurality of second electrodes having a second diameter, and wherein each of the plurality of second electrodes comprises;

a proximal end;

a distal end;

a first conductive portion intermediate the proximal end and the distal end;

a non-conductive portion intermediate the first conductive portion and the distal end; and

a second conductive portion at the distal end;

a grounding pad comprising a non-conductive outer region and a conductive inner region, wherein the grounding pad further defines a hole, and wherein the first electrode is positioned within the hole; and

an energy source coupled to the first electrode and the plurality of second electrodes, wherein the energy source is configured to deliver a series of electrical pulses to tissue to induce cell necrosis by irreversible electroporation; and

wherein the first diameter is greater than the second diameter.

2. An ablation apparatus, comprising:

a first electrode having a first diameter;

a plurality of second electrodes, each of the plurality of second electrodes having a second diameter, and wherein each of the plurality of second electrodes comprises;

a proximal end;

a distal end;

a first conductive portion intermediate the proximal end and the distal end;

a non-conductive portion intermediate the first conductive portion and the distal end; and

a second conductive portion at the distal end;

a grounding pad comprising a non-conductive outer region and a conductive inner region, wherein the first electrode does not contact the conductive inner region of the grounding pad; and

an energy source coupled to the first electrode and the plurality of second electrodes, wherein the energy source is configured to deliver a series of electrical pulses to tissue to induce cell necrosis by irreversible electroporation; and

wherein the first diameter is greater than the second diameter.

3. The ablation apparatus of claim 2, wherein the first conductive portion of each of the plurality of second electrodes is positioned in contact with the conductive inner region of the grounding pad.

4. The ablation apparatus of claim 3, wherein the first electrode is advanced into the tissue a first distance, wherein each of the plurality of second electrodes is advanced into the tissue a second distance, and wherein the first distance is greater than the second distance.

5. The ablation apparatus of claim 2, wherein the series of electrical pulses are characterized by amplitudes in a range of about ±

100 VDC to about ±

10,000 VDC, pulse widths in a range of about 1 μ

s to about 100 ms, and frequencies in a range of about 1 Hz to about 10,000 Hz.

6. The ablation apparatus of claim 2, wherein the ablation apparatus is electrically monopolar.

7. An ablation apparatus, comprising:

a first electrode;

a plurality of second electrodes, wherein each second electrode comprises;

a proximal end;

a distal end;

a first conductive portion intermediate the proximal end and the distal end;

a non-conductive portion intermediate the first conductive portion and the distal end; and

a second conductive portion at the distal end;

a grounding pad, wherein the grounding pad defines a hole, and wherein the first electrode is configured for insertion through the hole; and

an energy source electrically coupled to the first electrode and the plurality of second electrodes, wherein the energy source is configured to deliver a series of electrical pulses to tissue to induce cell necrosis by irreversible electroporation.

8. The ablation apparatus of claim 7, wherein the first electrode comprises a first diameter, wherein each second electrode comprises a second diameter, and wherein the first diameter is greater than or equal to the second diameter.

9. The ablation apparatus of claim 7, wherein the first electrode is configured for advancement into the tissue to a first distance, and wherein each second electrode is configured for advancement into the tissue to a second distance.

10. The ablation apparatus of claim 9, wherein the first distance is greater than or equal to the second distance, and wherein the first distance is suitable to create a necrotic zone.

11. The ablation apparatus of claim 9, wherein the first electrode is configured for advancement into the tissue to the first distance under ultrasound guidance.

12. An ablation apparatus, comprising:

a first electrode;

a plurality of second electrodes, wherein each second electrode comprises;

a proximal end;

a distal end;

a first conductive portion intermediate the proximal end and the distal end;

a non-conductive portion intermediate the first conductive portion and the distal end; and

a second conductive portion at the distal end;

a grounding pad, wherein the grounding pad comprises a non-conductive outer region, a conductive inner region, and defines a hole; and

an energy source electrically coupled to the first electrode and the plurality of second electrodes, wherein the energy source is configured to deliver a series of electrical pulses to tissue to induce cell necrosis by irreversible electroporation.

13. The ablation apparatus of claim 12, wherein each second electrode is positioned around the hole of the grounding pad.

14. The ablation apparatus of claim 12, wherein each second electrode is positioned around the hole of the grounding pad and above or around one or more bones.

15. The ablation apparatus of claim 12, wherein the first electrode is configured for insertion through the hole and into the tissue to a first distance, and wherein each second electrode is configured for insertion through the grounding pad and into the tissue to a second distance.

16. The ablation apparatus of claim 15, wherein the first conductive portion of each second electrode is positioned in contact with the conductive inner region of the grounding pad, and wherein the non-conductive portion of each second electrode is positioned in contact with the non-conductive outer region of the grounding pad.

17. An ablation device for coupling to an energy source delivering a series of electrical pulses to tissue to induce cell necrosis by irreversible electroporation, wherein the ablation device comprises:

a first electrode coupleable to the energy source;

a plurality of second electrodes, wherein each second electrode is coupleable to the energy source, and wherein each second electrode comprises;

a first conductive section;

a second conductive section; and

a non-conductive section between the first conductive section and the second conductive section; and

a grounding pad, wherein the grounding pad defines a hole, and wherein the first electrode is insertable through the hole.

18. The ablation device of claim 17, wherein the first electrode comprises a first diameter and each second electrode comprises a second diameter.

19. The ablation device of claim 17, wherein the grounding pad comprises a non-conductive outer region and a conductive inner region, wherein the first conductive section of each second electrode is positioned in contact with the conductive inner region, wherein the non-conductive section of each second electrode is positioned in contact with the non-conductive outer region, and wherein the second conductive section of each second electrode is configured for advancement into tissue.

20. An ablation device for coupling to an energy source delivering a series of electrical pulses to tissue to induce cell necrosis by irreversible electroporation, wherein the ablation device comprises:

a first electrode coupleable to the energy source;

a plurality of second electrodes, wherein each second electrode is coupleable to the energy source, and wherein each second electrode comprises;

a first conductive section;

a second conductive section; and

a non-conductive section between the first conductive section and the second conductive section; and

a grounding pad, wherein the grounding pad defines a hole, and wherein the first electrode is configured for insertion through the hole and into tissue to a first distance, and wherein each second electrode is configured for insertion through the grounding pad and into the tissue to a second distance.