Atrial tracking in an intracardiac ventricular pacemaker

• US 10,286,214 B2
• Filed: 11/03/2016
• Issued: 05/14/2019
• Est. Priority Date: 11/03/2016
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Demmer, Wade M, Cho, Yong K, Erickson, Mark K, Hess, Michael F, Sheldon, Todd J, Splett, Vincent E
• Primary Examiner(s): Wu, Eugene T
• Application Number:
  US15/342,699
• Publication Number:
  US 20180117337A1
• Time in Patent Office: 922 Days
• CPC Class Codes: A61N 1/0573 chacterised by means penetrating the heart tissue, e.g. helix needle or hook
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36578 controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

An intracardiac ventricular pacemaker having a motion sensor is configured to produce a motion signal including an atrial systolic event and at least one ventricular diastolic event. The pacemaker is configured to set an atrial refractory period, detect a change in a ventricular diastolic event metric and adjust the atrial refractory period in response to detecting the change. The pacemaker sets set an atrioventricular pacing interval in response to detecting the atrial systolic event from the motion signal after expiration of the atrial refractory period.

Claims

1. An intracardiac ventricular pacemaker, comprising:

a pulse generator configured to generate and deliver pacing pulses to a ventricle of a patient'"'"'s heart via electrodes coupled to the pacemaker;

a motion sensor configured to produce a motion signal comprising an atrial systolic event and at least one ventricular diastolic event; and

a control circuit coupled to the motion sensor and the pulse generator and configured to;

set an atrial refractory period;

determine a ventricular diastolic event metric from the motion signal;

compare the ventricular diastolic event metric to change criteria to detect a change in the ventricular diastolic event metric compared to at least one previously determined ventricular diastolic event metric;

adjust the atrial refractory period in response to detecting the change;

detect the atrial systolic event from the motion signal;

set an atrioventricular pacing interval in response to detecting the atrial systolic event after an expiration of the atrial refractory period; and

control the pulse generator to deliver a pacing pulse to a ventricle of the patient'"'"'s heart in response to the atrioventricular pacing interval expiring.

2. The pacemaker of claim 1, wherein:

the motion sensor signal comprises a first ventricular diastolic event occurring with ventricular relaxation of a patient'"'"'s heart and a second ventricular diastolic event occurring with passive ventricular filling;

the control circuit is configured to determine the ventricular diastolic event metric from at least one of the first ventricular diastolic event and the second ventricular diastolic event.

3. The pacemaker of claim 1, wherein the control circuit is configured to detect the change in the ventricular diastolic event metric by:

updating an average ventricular diastolic event metric using the ventricular diastolic event metric and at least one previously determined ventricular diastolic event metric; and

determining if the updated average ventricular diastolic event metric meets the change criteria.

4. The pacemaker of claim 2, wherein the control circuit is configured to set the atrial refractory period based on an expected time of the second ventricular diastolic event.

5. The pacemaker of claim 2, wherein the control circuit is configured to determine the ventricular diastolic event metric as a first ventricular diastolic event time interval from a preceding ventricular systolic event to the first ventricular diastolic event.

6. The pacemaker of claim 1, wherein the control circuit is further configured to:

identify a ventricular electrical event;

start a ventricular lower rate pacing interval in response to identifying the ventricular electrical event; and

adjust the ventricular lower rate pacing interval in response to detecting the change in the ventricular diastolic event metric.

7. The pacemaker of claim 1, wherein the control circuit is configured to:

determine if the detected atrial systolic event is an early atrial systolic event in a ventricular cycle by comparing a time of detection of the atrial systolic event to early detection criteria;

determine if the ventricular diastolic event metric has decreased compared to a previously determined ventricular diastolic event metric in response to determining that the detected atrial systolic event is an early atrial systolic event;

confirm the early atrial systolic event in response to the ventricular diastolic event metric being decreased; and

set the atrioventricular pacing interval in response to confirming the early atrial systolic event.

8. The pacemaker of claim 7, wherein the control circuit is further configured to:

responsive to determining the ventricular diastolic metric is not decreased, withhold setting the atrioventricular pacing interval in response to detecting the early atrial systolic event.

9. The pacemaker of claim 8, wherein the control circuit is further configured to:

detect a late atrial systolic event in the ventricular cycle in response to the motion signal crossing an atrial systolic event detection threshold amplitude after withholding the setting of the atrioventricular pacing interval; and

set the atrioventricular pacing interval in response to detecting the late atrial systolic event.

10. The pacemaker of claim 7, wherein the control circuit is further configured to:

determine that the detected atrial systolic event is an early atrial systolic event in response to the motion signal crossing an atrial systolic event detection threshold amplitude during the atrial refractory period.

11. The pacemaker of claim 7, wherein:

the motion sensor signal comprises a first ventricular diastolic event occurring with ventricular relaxation of a patient'"'"'s heart and a second ventricular diastolic event occurring with passive ventricular filling;

the control circuit is further configured to;

establish an expected time window of the second ventricular diastolic event; and

determine that the detected atrial systolic event is an early atrial systolic event in response to the motion signal crossing an atrial systolic event detection threshold amplitude during the expected time window of the second ventricular diastolic event.

12. The pacemaker of claim 11, wherein the control circuit is configured to:

determine an averaged motion signal;

detect the second ventricular diastolic event from the averaged motion signal;

establish the expected time window based on the second ventricular diastolic event detected from the averaged motion signal; and

set the atrial refractory period to expire based on a time of the second ventricular diastolic event in the averaged motion signal.

13. The pacemaker of claim 2, wherein the control circuit is configured to determine the ventricular diastolic event metric by determining a time interval from the second ventricular diastolic event to the atrial systolic event.

14. The pacemaker of claim 1, further comprising a housing enclosing the pulse generator, the motion sensor, and the control circuit, wherein the electrodes are housing-based electrodes.

15. A method performed by an intracardiac ventricular pacemaker having a motion sensor, comprising:

producing by the motion sensor a motion signal comprising an atrial systolic event and at least one ventricular diastolic event;

setting by a control circuit of the pacemaker an atrial refractory period;

determining by the control circuit a ventricular diastolic event metric from the motion signal;

comparing the ventricular diastolic event metric to change criteria to detect a change in the ventricular diastolic event metric compared to at least one previously determined ventricular diastolic event metric;

adjusting the atrial refractory period in response to detecting the change;

detecting the atrial systolic event from the motion signal;

setting an atrioventricular pacing interval in response to detecting the atrial systolic event after an expiration of the atrial refractory period; and

delivering a pacing pulse to a ventricle of the patient'"'"'s heart via electrodes coupled to the pacemaker in response to the atrioventricular pacing interval expiring.

16. The method of claim 15, wherein the motion sensor signal comprises a first ventricular diastolic event occurring with ventricular relaxation of a patient'"'"'s heart and a second ventricular diastolic event occurring with passive ventricular filling;

the method further comprising determining the ventricular diastolic event metric from at least one of the first ventricular diastolic event and the second ventricular diastolic event.

17. The method of claim 15, wherein detecting the change in the ventricular diastolic event metric comprises:

updating an average first ventricular diastolic event metric using the ventricular diastolic event metric and at least one previously determined ventricular diastolic event metric;

determining if the updated average ventricular diastolic event metric meets the change criteria.

18. The method of claim 16, further comprising setting the atrial refractory period based on an expected time of the second ventricular diastolic event.

19. The method of claim 16, further comprising determining the ventricular diastolic event metric as a first ventricular diastolic event time interval from a preceding ventricular systolic event to the first ventricular diastolic event.

20. The method of claim 15, further comprising:

identifying a ventricular electrical event;

starting a ventricular lower rate pacing interval in response to identifying the ventricular electrical event; and

adjusting the ventricular lower rate pacing interval in response to detecting the change in the ventricular diastolic event metric.

21. The method of claim 15, further comprising:

determining if the detected atrial systolic event is an early atrial systolic event in a ventricular cycle by comparing a time of detection to early detection criteria;

determining if the ventricular diastolic event metric has decreased compared to a previously determined ventricular diastolic event metric in response to determining that the detected atrial systolic event is an early atrial systolic event;

confirming the early atrial systolic event in response to the ventricular diastolic event metric being decreased; and

setting the atrioventricular pacing interval in response to confirming the early atrial systolic event.

22. The method of claim 21, further comprising:

responsive to the ventricular diastolic event metric not being decreased, withholding setting the atrioventricular pacing interval in response to detecting the early atrial systolic event.

23. The method of claim 22, further comprising:

detecting a late atrial systolic event in the ventricular cycle in response to the motion signal crossing an atrial systolic event detection threshold amplitude after withholding the setting of the atrioventricular pacing interval; and

setting the atrioventricular pacing interval in response to detecting the late atrial systolic event.

24. The method of claim 21, further comprising:

determining that the detected atrial systolic event is an early atrial systolic event in response to the motion signal crossing an atrial systolic event detection threshold amplitude during the atrial refractory period.

25. The method of claim 21, wherein:

the motion sensor signal comprises a first ventricular diastolic event occurring with ventricular relaxation of a patient'"'"'s heart and a second ventricular diastolic event occurring with passive ventricular filling;

the method further comprising;

establishing an expected time window of the second ventricular diastolic event; and

determining that the detected atrial systolic event is an early atrial systolic event in response to the motion signal crossing an atrial systolic event detection threshold amplitude during the expected time window of the second ventricular diastolic event.

26. The method of claim 25, further comprising:

determining an averaged motion signal;

detecting the second ventricular diastolic event from the averaged motion signal;

establishing the expected time window based on the second ventricular diastolic event detected from the averaged motion signal; and

setting the atrial refractory period to expire based on a time of the second ventricular diastolic event in the averaged motion signal.

27. The method of claim 16, wherein determining the ventricular diastolic event metric comprises determining a time interval from the second ventricular diastolic event to the atrial systolic event.

28. The method of claim 15, further comprising delivering the pacing pulse via housing-based electrodes carried by a housing enclosing the pulse generator, the motion sensor, and the control circuit.

29. A non-transitory computer-readable medium storing a set of instructions which when executed by a control circuit of an intracardiac ventricular pacemaker having a motion sensor, cause the pacemaker to:

produce by the motion sensor a motion signal comprising an atrial systolic event and at least one ventricular diastolic event;

set an atrial refractory period;

determine a ventricular diastolic event metric;

compare the ventricular diastolic event metric to change criteria to detect a change in the ventricular diastolic event metric compared to at least one previously determined ventricular diastolic event metric;

adjust the atrial refractory period in response to detecting the change;

detect the atrial systolic event from the motion signal;

set an atrioventricular pacing interval in response to detecting the atrial systolic event after an expiration of the atrial refractory period; and

deliver a pacing pulse to a ventricle of the patient'"'"'s heart via electrodes coupled to the pacemaker in response to the atrioventricular pacing interval expiring.