Thermal modulation of an inhalable medicament

• US 10,300,228 B2
• Filed: 08/25/2015
• Issued: 05/28/2019
• Est. Priority Date: 08/26/2014
• Status: Active Grant

• Current Assignee: Michael Edward Breede
• Original Assignee: InnovoSciences, LLC
• Inventors: Minskoff, Noah Mark
• Primary Examiner(s): Lee, Joshua
• Application Number:
  US14/835,595
• Publication Number:
  US 20160228658A1
• Time in Patent Office: 1,372 Days
• CPC Class Codes: A61M 11/042 electrical
• CPC Class Codes: A61M 15/0005 with means for agitating the medicament
• CPC Class Codes: A61M 15/0033 Details of the piercing or cutting means
• CPC Class Codes: A61M 15/0036 hollow piercing means
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 15/02 with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
• CPC Class Codes: A61M 16/04 Tracheal tubes catheters in general A61M25/00
• CPC Class Codes: A61M 16/1075 by influencing the temperature A61M16/1045 takes precedence
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 2205/36 related to heating or cooling
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/505 Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 2205/8225 using incorporated gas cartridges for the driving gas
• CPC Class Codes: A61M 2230/50 Temperature

Abstract

A thermally modulating inhalable medicament delivery device may deliver an inhalable medicament as an aerosol, vapor, or partial aerosol and partial vapor mixture. The inhalable medicament may be delivered to a target in a subject. Described herein are devices, systems, and methods for delivering an inhalable medicament to a subject.

Claims

1. A method for delivering an inhalable medicament, comprising:

coupling a cartridge to a housing with a reservoir tap having a hollow interior, the cartridge comprising;

a penetrable seal positioned adjacent to the reservoir tap when the cartridge is coupled to the housing; and

an inhalable medicament within the cartridge that is compressed to a pressure above ambient pressure; and

penetrating said penetrable seal with the reservoir tap, aerosolizing the inhalable medicament and ejecting said inhalable medicament into the housing.

2. The method of claim 1, wherein penetrating the penetrable seal comprises penetrating a self-sealing penetrable seal.

3. The method of claim 1, further comprising:

heating the inhalable medicament.

4. The method of claim 3, wherein heating the inhalable medicament comprises heating the inhalable medicament within the housing.

5. The method of claim 1, wherein penetrating the penetrable seal comprises sliding the reservoir tap within the housing.

6. The method of claim 1, further comprising:

creating communication between the cartridge and the hollow interior of the reservoir tap with a port of the reservoir tap when penetrating the penetrable seal with the reservoir tap.

7. The method of claim 1, wherein coupling the cartridge to the housing comprises coupling a cartridge including the inhalable medicament substantially in liquid form to the housing.

8. A method for delivering an inhalable medicament with an orientation-independent system, comprising:

penetrating a seal of a cartridge to enable communication of an inhalable medicament at an above-ambient pressure from a medicament reservoir of the cartridge, positioned adjacent to the seal, to a housing of a device capable of delivering the inhalable medicament; and

releasing the inhalable medicament from the medicament reservoir upon establishing communication between the medicament reservoir and the housing.

9. The method of claim 8, wherein penetrating the seal comprises penetrating a self-sealing seal.

10. The method of claim 8, further comprising:

coupling the cartridge to the housing of the device capable of delivering the inhalable medicament, wherein penetrating the seal comprises penetrating the seal with a reservoir tap of the device.

11. The method of claim 10, wherein penetrating the seal comprises sliding the reservoir tap into the seal.

12. The method of claim 11, wherein releasing the inhalable medicament occurs upon penetrating the seal.

13. The method of claim 12, further comprising:

heating the medicament within the housing of the device capable of delivering the inhalable medicament.