Methods and systems for neural stimulation via visual, auditory and peripheral nerve stimulations

• US 10,307,611 B2
• Filed: 11/17/2017
• Issued: 06/04/2019
• Est. Priority Date: 11/17/2016
• Status: Active Grant

• Current Assignee: Cognito Therapeutics, Inc.
• Original Assignee: Cognito Therapeutics, Inc.
• Inventors: Malchano, Zachary John Hambrecht, Williams, Martin Warren
• Primary Examiner(s): Malamud, Deborah L
• Application Number:
  US15/816,238
• Publication Number:
  US 20180133507A1
• Time in Patent Office: 564 Days
• CPC Class Codes: A61B 3/113 for determining or recording eye movement
• CPC Class Codes: A61B 5/0036 including treatment, e.g., using an implantable medical device, ablating, ventilating
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/16 Devices for psychotechnics using teaching or educational appliances G09B1/00 - G09B7/00; Testing reaction times ; Devices for evaluating the psychological state
• CPC Class Codes: A61B 5/163 by tracking eye movement, gaze, or pupil change
• CPC Class Codes: A61B 5/168 Evaluating attention deficit, hyperactivity
• CPC Class Codes: A61B 5/375 using biofeedback
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/378 Visual stimuli
• CPC Class Codes: A61B 5/38 Acoustic or auditory stimuli
• CPC Class Codes: A61B 5/398 Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
• CPC Class Codes: A61B 5/4088 Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication
• CPC Class Codes: A61B 5/6803 Head-worn items, e.g. helmets, masks, headphones or goggles
• CPC Class Codes: A61M 2021/0027 by the hearing sense
• CPC Class Codes: A61M 2021/0044 by the sight sense
• CPC Class Codes: A61M 2021/0072 with application of electrical currents
• CPC Class Codes: A61M 21/00 Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
• CPC Class Codes: A61M 2205/3375 : Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61N 1/0456 : Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/0551 : Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36025 : for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36036 : of the outer, middle or inner ear
• CPC Class Codes: A61N 1/36082 : Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36092 : Mental training
• CPC Class Codes: A61N 1/36132 : using patient feedback
• CPC Class Codes: A61N 2005/0626 : Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 2005/0627 : Dose monitoring systems and methods
• CPC Class Codes: A61N 2005/0629 : Sequential activation of light sources
• CPC Class Codes: A61N 2005/0648 : the light being directed to the eyes
• CPC Class Codes: A61N 2005/0652 : Arrays of diodes
• CPC Class Codes: A61N 2005/0659 : infrared
• CPC Class Codes: A61N 2005/0661 : ultraviolet
• CPC Class Codes: A61N 2005/0662 : Visible light
• CPC Class Codes: A61N 2005/0663 : Coloured light
• CPC Class Codes: A61N 2005/0667 : Filters
• CPC Class Codes: A61N 5/0618 : Psychological treatment
• CPC Class Codes: A61N 5/0622 : Optical stimulation for exciting neural tissue
• CPC Class Codes: G02C 11/10 : Electronic devices other than hearing aids
• CPC Class Codes: G02C 2200/10 : Frame or frame portions made from wire
• CPC Class Codes: G16H 10/20 : for electronic clinical trials or questionnaires
• CPC Class Codes: G16H 10/60 : for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 20/10 : relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 20/70 : relating to mental therapies, e.g. psychological therapy or autogenous training
• CPC Class Codes: G16H 40/63 : for local operation
• CPC Class Codes: G16H 40/67 : for remote operation
• CPC Class Codes: G16H 70/20 : relating to practices or guidelines
• CPC Class Codes: H05B 47/105 : in response to determined parameters

Abstract

Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include a light source and a speaker. A visual neural stimulation system provides, via the light source, visual stimulation having a first value of a first parameter. An auditory neural stimulation system provides, via the speaker, audio stimulation having a second value of the second parameter. A stimuli orchestration component selects, for a first time interval, one of the visual stimulation or the audio stimulation to vary based on a policy, selects, for the first time interval, the other of the visual stimulation or the audio stimulation to keep constant based on the policy, and provides causes the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation.

Claims

1. A system for treating cognitive dysfunction in a subject in need thereof, comprising:

a light source;

a speaker;

a visual signaling component executed by a visual neural stimulation system and configured to provide, via the light source, visual stimulation having a first value of a first parameter;

an audio signaling component executed by an auditory neural stimulation system configured to provide, via the speaker, audio stimulation having a second value of the second parameter; and

a stimuli orchestration component executed by a neural stimulation orchestration system and configured to;

receive an indication of an ambient condition and an indication of a physiological condition of the subject;

select, for a first time interval, an offset between the visual stimulation and the audio stimulation to vary based on a policy and the indication of the ambient condition and the indication of the physiological condition of the subject, and

provide instructions to at least one of the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected offset between the visual stimulation and the audio stimulation to vary to cause the at least one of the visual neural stimulation system or the auditory neural stimulation system to vary the offset between the visual stimulation and the audio stimulation.

2. The system of claim 1, wherein the neural stimulation orchestration system is further configured to:

select, for a second time interval subsequent to the first time interval, one of the visual stimulation or the audio stimulation to vary based on the policy;

select, for the second time interval, the other of the visual stimulation or the audio stimulation to keep constant based on the policy; and

provide instructions to the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected one of the visual stimulation or the audio stimulation to vary during the second time interval to cause the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation during the second time interval.

3. The system of claim 1, comprising:

a feedback monitor configured to detect the physiological condition of the subject during the first time interval,

wherein the neural stimulation orchestration system is further configured to select, using the policy and based on the detected physiological condition, one of the visual stimulation or the audio stimulation to vary during the first time interval.

4. The system of claim 1, comprising:

a microphone configured to detect an ambient sound level; and

a photodiode configured to detect an ambient light level,

wherein the neural stimulation orchestration system is further configured to select, based on the ambient sound level and the ambient light level, one of the visual stimulation or the audio stimulation to vary during the first time interval.

5. The system of claim 1, comprising:

an electrode to provide peripheral nerve stimulation to the subject, wherein

wherein the neural stimulation orchestration system is further configured to select, based on the policy, one of the visual stimulation, the audio stimulation, or the peripheral nerve stimulation to vary during a second time interval.

6. The system of claim 1, wherein the visual stimulation is selected for varying during the first time interval, the system comprising:

an electrode to provide peripheral nerve stimulation to the subject during the first time interval; and

a feedback monitor configured to detect the physiological condition of the subject during the first time interval,

wherein the neural stimulation orchestration system is further configured to;

select, responsive to detecting the physiological condition, one of the audio stimulation or the peripheral nerve stimulation to vary during a second time interval subsequent to the first time interval;

select, for the second time interval, the visual stimulation to keep constant;

provide instructions to the visual neural stimulation system to keep constant during the second time interval;

provide instructions to the auditory neural stimulation system to vary during the second time interval; and

provide instructions to the electrode to keep constant during the second time interval.

7. The system of claim 1, wherein the cognitive dysfunction comprises Alzheimer'"'"'s disease.

8. The system of claim 1, comprising:

a feedback monitor configured to detect the physiological condition of the subject during the first time interval,

wherein the neural stimulation orchestration system is further configured to;

select, responsive to detecting the physiological condition, the of the visual stimulation or the audio stimulation to vary during a second time interval subsequent to the first time interval;

select, for the second time interval, the other of the visual stimulation or the audio stimulation to keep constant; and

provide instructions to the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected one of the visual stimulation or the audio stimulation to vary during the second time interval to cause the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation during the second time interval.

9. A system for treating cognitive dysfunction in a subject in need thereof, comprising:

a visual neural stimulation system configured to provide, via a light output source, visual stimulation having a first value of a first parameter;

an auditory neural stimulation system configured to provide, via an audio output source, audio stimulation having a second value of the second parameter; and

a neural stimulation orchestration system configured to;

receive an indication of an ambient condition and an indication of a physiological condition of the subject;

select, for a first time interval, an offset between the visual stimulation and the audio stimulation to vary based on a policy and the indication of the ambient condition and the indication of the physiological condition of the subject, and

provide instructions to at least one of the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected offset between the visual stimulation and the audio stimulation to vary to cause the at least one of the visual neural stimulation system or the auditory neural stimulation system to vary the offset between the visual stimulation and the audio stimulation.

10. The system of claim 9, wherein the neural stimulation orchestration system is further configured to:

select, for a second time interval subsequent to the first time interval, one of the visual stimulation or the audio stimulation to vary based on the policy;

select, for the second time interval, the other of the visual stimulation or the audio stimulation to keep constant based on the policy; and

provide instructions to the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected one of the visual stimulation or the audio stimulation to vary during the second time interval to cause the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation during the second time interval.

11. The system of claim 9, comprising:

a feedback monitor configured to detect the physiological condition of the subject during the first time interval,

wherein the neural stimulation orchestration system is further configured to select, using the policy and based on the detected physiological condition, one of the visual stimulation or the audio stimulation to vary during the first time interval.

12. The system of claim 9, comprising:

a feedback monitor configured to detect the physiological condition of the subject during the first time interval,

wherein the neural stimulation orchestration system is further configured to;

select, responsive to detecting the physiological condition, one of the visual stimulation or the audio stimulation to vary during a second time interval subsequent to the first time interval;

select, for the second time interval, the other of the visual stimulation or the audio stimulation to keep constant; and

provide instructions to the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected one of the visual stimulation or the audio stimulation to vary during the second time interval to cause the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation during the second time interval.

13. The system of claim 9, comprising:

a microphone configured to detect an ambient sound level; and

a photodiode configured to detect an ambient light level,

wherein the neural stimulation orchestration system is further configured to select, based on the ambient sound level and the ambient light level, one of the visual stimulation or the audio stimulation to vary during the first time interval.

14. The system of claim 9, comprising:

an electrode to provide peripheral nerve stimulation to the subject,

wherein the neural stimulation orchestration system is further configured to select, based on the policy, one of the visual stimulation, the audio stimulation, or the peripheral nerve stimulation to vary during a second time interval.

15. The system of claim 9, wherein the visual stimulation is selected for varying during the first time interval, the system comprising:

an electrode to provide peripheral nerve stimulation to the subject during the first time interval; and

a feedback monitor configured to detect the physiological condition of the subject during the first time interval,

wherein the neural stimulation orchestration system is further configured to;

select, responsive to detecting the physiological condition, one of the audio stimulation or the peripheral nerve stimulation to vary during a second time interval subsequent to the first time interval;

select, for the second time interval, the visual stimulation to keep constant;

provide instructions to the visual neural stimulation system to keep constant during the second time interval;

provide instructions to the auditory neural stimulation system to vary during the second time interval; and

provide instructions to the electrode to keep constant during the second time interval.

16. The system of claim 9, wherein the cognitive dysfunction comprises Alzheimer'"'"'s disease.

17. A system for treating cognitive dysfunction in a subject in need thereof, comprising:

a visual neural stimulation system;

an auditory neural stimulation system;

a neural stimulation orchestration system;

a light output source;

an audio output source; and

one or more processors configured to execute one or more programs to treat a subject in need of a treatment of a brain disease, the one or more programs including instructions for conducting a therapy session, the therapy session comprising;

providing, via the light output source, visual stimulation having a first value of a first parameter;

providing, via the audio output source, audio stimulation having a second value of the second parameter;

receiving an indication of an ambient condition and an indication of a physiological condition of the subject;

selecting, for a first time interval, an offset between the visual stimulation and the audio stimulation to vary based on a policy and the indication of the ambient condition and the indication of the physiological condition of the subject, and

providing instructions to at least one of the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected offset between the visual stimulation and the audio stimulation to vary to cause the at least one of the visual neural stimulation system or the auditory neural stimulation system to vary the offset between the visual stimulation and the audio stimulation.

18. The system of claim 17, wherein the therapy session comprises:

selecting, for a second time interval subsequent to the first time interval, the other of the visual stimulation or the audio stimulation to vary based on the policy;

selecting, for the second time interval, the other of the visual stimulation or the audio stimulation to keep constant based on the policy; and

providing instructions to the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected one of the visual stimulation or the audio stimulation to vary during the second time interval to cause the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation during the second time interval.

19. The system of claim 17, wherein the therapy session comprises:

detecting the physiological condition of the subject during the first time interval,

selecting, using the policy and based on the detected physiological condition, one of the visual stimulation or the audio stimulation to vary during the first time interval.

20. The system of claim 17, wherein the therapy session comprises:

detecting the physiological condition of the subject during the first time interval;

selecting, responsive to detecting the physiological condition, the other of the visual stimulation or the audio stimulation to vary during a second time interval subsequent to the first time interval;

selecting, for the second time interval, the other of the visual stimulation or the audio stimulation to keep constant; and

providing instructions to the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected one of the visual stimulation or the audio stimulation to vary during the second time interval to cause the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation during the second time interval.

21. The system of claim 17, wherein the therapy session comprises:

detecting an ambient sound level;

detecting an ambient light level; and

selecting, based on the ambient sound level and the ambient light level, one of the visual stimulation or the audio stimulation to vary during the first time interval.

22. The system of claim 17, wherein the therapy session comprises:

providing, via an electrode, peripheral nerve stimulation to the subject; and

selecting, based on the policy, one of the visual stimulation, the audio stimulation, or the peripheral nerve stimulation to vary during a second time interval.

23. The system of claim 17, wherein the visual stimulation is selected for varying during the first time interval, the therapy session further comprising:

providing, via an electrode, peripheral nerve stimulation to the subject during the first time interval;

detecting the physiological condition of the subject during the first time interval;

selecting, responsive to detecting the physiological condition, one of the audio stimulation or the peripheral nerve stimulation to vary during a second time interval subsequent to the first time interval;

selecting, for the second time interval, the visual stimulation to keep constant;

providing instructions to the visual neural stimulation system to keep constant during the second time interval;

providing instructions to the auditory neural stimulation system to vary during the second time interval; and

providing instructions to the electrode to keep constant during the second time interval.

24. The system of claim 17, wherein the cognitive dysfunction comprises Alzheimer'"'"'s disease.

25. A method for treating cognitive dysfunction in a subject in need thereof, comprising administering a stimulus to the subject using a system comprising:

a light source;

a speaker;

a visual signaling component executed by a visual neural stimulation system and configured to provide, via the light source, visual stimulation having a first value of a first parameter;

an audio signaling component executed by an auditory neural stimulation system configured to provide, via the speaker, audio stimulation having a second value of the second parameter; and

a stimuli orchestration component executed by a neural stimulation orchestration system and configured to;

receive an indication of an ambient condition and an indication a physiological condition of the subject;

select, for a first time interval, an offset between the visual stimulation and the audio stimulation to vary based on a policy and the indication of the ambient condition and the indication of the physiological condition of the subject, and

provide instructions to at least one of the visual neural stimulation system or the auditory neural stimulation system corresponding to the selected offset between the visual stimulation and the audio stimulation to vary to cause the at least one of the visual neural stimulation system or the auditory neural stimulation system to vary the offset between the visual stimulation and the audio stimulation.

26. The method of claim 25, wherein the cognitive dysfunction comprises Alzheimer'"'"'s disease.