Device and method for providing a synergistic combination of phototherapy and a non-light energy modality to the brain
First Claim
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1. A method for treating a patient'"'"'s brain, comprising:
- administering, to a target tissue of the patient'"'"'s brain, an amount of light energy; and
administering, to the target tissue of the patient'"'"'s brain, an amount of non-light energy, wherein the amount of non-light energy is a subtherapeutic amount of energy,wherein the administrations of the amount of light energy and the amount of non-light energy occur within 24 hours of each other,wherein the administrations of the amount of light energy and the amount of non-light energy produce a combined treatment effect to the patient that is greater than a sum of;
(i) a treatment effect produced by administering the amount of light energy alone plus (ii) a treatment effect produced by administering the amount of non-light energy alone, andwherein the time-averaged irradiance of the amount of light energy at the target tissue of the patient'"'"'s brain is less than 100 mW/cm2.
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Abstract
Systems and methods that could reduce the potential for side effects while delivering a reduced amount of light energy and non-light energy to a patient while providing a desired therapeutic effect that might otherwise only be achievable with a higher dose of either the light energy or non-light energy administered alone are disclosed. In certain embodiments, disclosed is a system and method for treating a patient, by administering a combination of light therapy from a light energy source in addition to one, two, or more other non-light energy modalities to a target region of a patient for a synergistic therapeutic effect.
33 Citations
16 Claims
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1. A method for treating a patient'"'"'s brain, comprising:
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administering, to a target tissue of the patient'"'"'s brain, an amount of light energy; and administering, to the target tissue of the patient'"'"'s brain, an amount of non-light energy, wherein the amount of non-light energy is a subtherapeutic amount of energy, wherein the administrations of the amount of light energy and the amount of non-light energy occur within 24 hours of each other, wherein the administrations of the amount of light energy and the amount of non-light energy produce a combined treatment effect to the patient that is greater than a sum of;
(i) a treatment effect produced by administering the amount of light energy alone plus (ii) a treatment effect produced by administering the amount of non-light energy alone, andwherein the time-averaged irradiance of the amount of light energy at the target tissue of the patient'"'"'s brain is less than 100 mW/cm2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for treating a patient'"'"'s brain, comprising:
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administering, to a target tissue of the patient'"'"'s brain, an amount of light energy; and administering, to the target tissue of the patient'"'"'s brain, an amount of non-light energy, wherein the amount of non-light energy is a subtherapeutic amount of energy, wherein the administration of the amount of light energy and the amount of non-light energy occur within 24 hours of each other, and wherein the administrations of the amount of light energy and the amount of non-light energy produce a combined treatment effect to the patient that is greater than a sum of;
(i) a treatment effect produced by administering the amount of light energy alone plus (ii) a treatment effect produced by administering the amount of non-light energy alone. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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Specification