Method and device for displaying predicted volume of influence
First Claim
1. A system for determining an estimated volume of tissue activated by at least one electrode implanted in an anatomical region of a patient, the system comprising:
- a display device; and
a processor coupled to the display device and configured to perform steps comprising;
calculating, using an anatomical model that characterizes a location of the at least one electrode in the anatomical region and an electrical model that characterizes an electric field generated in the anatomical region, a spatial distribution of electrical values to be generated by the at least one electrode using a first set of settings over a plurality of positions in the patient'"'"'s tissue;
determining at least one threshold value for tissue activation;
determining, by applying the at least one threshold value to the spatial distribution of the electrical values, an estimated volume of tissue activated by the at least one electrode using the first set of settings; and
outputting, on the display device, a graphical representation of the determined estimated volume.
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Abstract
This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, volumetric imaging data representing an anatomical volume of a brain of a patient can be obtained and transformed to brain atlas data. A patient-specific brain atlas can be created using the inverse of the transformation to map the brain atlas data onto the volumetric imaging data and a volume of influence can be calculated using the patient-specific brain atlas. In certain examples, the volume of influence can include a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location.
444 Citations
20 Claims
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1. A system for determining an estimated volume of tissue activated by at least one electrode implanted in an anatomical region of a patient, the system comprising:
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a display device; and a processor coupled to the display device and configured to perform steps comprising; calculating, using an anatomical model that characterizes a location of the at least one electrode in the anatomical region and an electrical model that characterizes an electric field generated in the anatomical region, a spatial distribution of electrical values to be generated by the at least one electrode using a first set of settings over a plurality of positions in the patient'"'"'s tissue; determining at least one threshold value for tissue activation; determining, by applying the at least one threshold value to the spatial distribution of the electrical values, an estimated volume of tissue activated by the at least one electrode using the first set of settings; and outputting, on the display device, a graphical representation of the determined estimated volume. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A system for determining an estimated volume of tissue activated by at least one electrode implanted inside a patient, the system comprising:
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a display device; and a processor coupled to the display device and configured to perform steps comprising; determining a distribution of electrical values to be generated by the at least one electrode using a first set of settings over a plurality of positions in the patient'"'"'s tissue by creating a finite element model of the at least one electrode and tissue around the at least one electrode; determining at least one threshold value for tissue activation; determining, by applying the at least one threshold value to the electrical values, an estimated volume of tissue activated by the at least one electrode using the first set of settings; and outputting, on the display device, a graphical representation of the determined estimated volume. - View Dependent Claims (13, 14)
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15. A system for determining an estimated volume of tissue activated by at least one electrode implanted inside a patient, the system comprising:
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a display device; and a processor coupled to the display device and configured to perform steps comprising; determining a distribution of electrical values to be generated by the at least one electrode using a first set of settings over a plurality of positions in the patient'"'"'s tissue; determining at least one threshold value for tissue activation; determining, by applying the at least one threshold value to the electrical values, an estimated volume of tissue activated by the at least one electrode using the first set of settings; outputting, on the display device, a graphical representation of the determined estimated volume; and determining a score for the estimated volume of tissue based on at least one criteria selected from a) one or more regions of tissue in which activation is desired or b) one or more regions of tissue in which activation should be avoided. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification