Medicament delivery devices with wireless connectivity and event detection

• US 10,332,623 B2
• Filed: 01/16/2018
• Issued: 06/25/2019
• Est. Priority Date: 01/17/2017
• Status: Active Grant

• Current Assignee: Kaleo, Inc.
• Original Assignee: Kaleo, Inc.
• Inventors: Edwards, Eric S., Edwards, Evan T., Meyers, Paul F., Briggs, Samuel Jefferson, Perkins, George McGee, Van Wyk, Eugene Johannes, Burke, Mitchell Frederick, Scammell, Eric William
• Primary Examiner(s): Lau, Hoi C
• Application Number:
  US15/872,162
• Publication Number:
  US 20180204636A1
• Time in Patent Office: 525 Days
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/3553 remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/2053 Media being expelled from injector by pressurised fluid or vacuum for infusion A61M5/145, A61M5/155
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/67 for remote operation
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

A computer-implemented method includes establishing a communications link, via a short-range wireless protocol, between a mobile computing device and a medicament delivery device. A user input selecting a motion profile of the medicament delivery device is then received in response to an input prompt. A wireless signal is received from the medicament delivery device, the wireless signal associated with an actual motion profile of the medicament delivery device. A notification is produced to indicate a motion difference between the actual motion profile and the target motion profile. In some embodiments, the method optionally includes modifying the target motion profile based on the motion profile over a time period of at least one week, the notification indicating a motion difference between the motion profile and the modified target motion profile.

Claims

1. A computer-implemented method, comprising:

establishing a communications link, via a short-range wireless protocol, between a mobile computing device and a medicament delivery device;

receiving, in response to an input prompt, a user input selecting a target motion profile of the medicament delivery device, the target motion profile including one of an on-person motion profile or a fixed location motion profile;

receiving, from the medicament delivery device, a wireless signal associated with an actual motion profile of the medicament delivery device, the actual motion profile including any of a position, a velocity, an acceleration, or an orientation of the medicament delivery device during a time period;

analyzing the actual motion profile to determine if a magnitude of the actual motion profile is outside of a threshold associated with the target motion profile, the magnitude of the actual motion profile including an amount of a change in the position of the medicament delivery device during the time period; and

producing a notification when the magnitude of the actual motion profile is outside of the threshold, the notification indicating that the magnitude is outside of the threshold associated with the target motion profile.

2. The computer-implemented method of claim 1, wherein the time period is at least one week, and the actual motion profile is a second actual motion profile, the method further comprising:

modifying the target motion profile based on a first actual motion profile over the time period, the notification indicating a motion difference between the second actual motion profile and the modified target motion profile.

3. The computer-implemented method of claim 1, wherein the time period is at least 24 hours.

4. The computer-implemented method of claim 1, wherein the wireless signal is a first wireless signal and the notification is a first notification, the method further comprising:

receiving, from the medicament delivery device, a second wireless signal to maintain the communications link, the second wireless signal being periodic;

determining, based on the second wireless signal, a relative position between the mobile computing device and the medicament delivery device; and

producing a second notification when the relative position exceeds a relative position threshold.

5. The computer-implemented method of claim 4, wherein:

the time period is a first time period; and

the producing the second notification includes producing the second notification when the second wireless signal is not received within a second time period.

6. The computer-implemented method of claim 1, wherein the medicament delivery device is any one of an auto-injector, a pen injector, a medication pump, a prefilled syringe, a nasal delivery device or an inhaler.

7. The computer-implemented method of claim 1, wherein the medicament delivery device is a first medicament delivery device, the input prompt is a first input prompt, the user input is a first user input, the wireless signal is a first wireless signal, the target motion profile of the first medicament delivery device is the on-person motion profile, and the notification is a first notification indicating that a change in the position of the first medicament delivery device during the time period is below the threshold associated with the on-person motion profile, the method further comprising:

establishing a second communications link, via the short-range wireless protocol, between the mobile computing device and a second medicament delivery device;

receiving, in response to a second input prompt, a second user input selecting the fixed location motion profile for the second medicament delivery device;

receiving, from the second medicament delivery device, a second wireless signal associated with an actual motion profile of the second medicament delivery device; and

suppressing a second notification indicating that a change in a position of the second medicament delivery device during the time period is below the threshold associated with the on-person motion profile.

8. The computer-implemented method of claim 1, wherein the wireless signal is a first wireless signal and the notification is a first notification, the method further comprising:

receiving, from the medicament delivery device, a second wireless signal associated with a temperature profile of the medicament delivery device; and

producing a second notification when the temperature profile is outside of a predetermined temperature range.

9. The computer-implemented method of claim 1, wherein the wireless signal is a first wireless signal, the method further comprising:

receiving, from the medicament delivery device, a second wireless signal associated with a temperature profile of the medicament delivery device, the notification is based on both a motion difference between the actual motion profile and the target motion profile and a temperature difference between the temperature profile and a predetermined temperature range.

10. The computer-implemented method of claim 1, wherein the producing the notification is performed by a first application that is executed by a processor of the mobile computing device, the wireless signal is a first wireless signal and the notification is a first notification, the method further comprising:

receiving, from the medicament delivery device, a second wireless signal associated with a temperature profile of the medicament delivery device;

receiving, from a second application executed by the processor of the mobile computing device, a temperature information;

determining, within the first application and based on the temperature information received from the second application, a temperature range; and

producing a second notification when the temperature profile is outside of the temperature range.

11. A computer-implemented method, comprising:

establishing a first communications link, via a short-range wireless protocol, between a mobile computing device and a first medicament delivery device;

establishing a second communications link, via the short-range wireless protocol, between the mobile computing device and a second medicament delivery device;

receiving, in response to a first input prompt, a first user input selecting an on-person target motion profile of the first medicament delivery device;

receiving, in response to a second input prompt, a second user input selecting a fixed location target motion profile for the second medicament delivery device;

receiving, from the first medicament delivery device, a first wireless signal associated with a first actual motion profile of the first medicament delivery device, the first actual motion profile including any of a position, a velocity, an acceleration, or an orientation of the first medicament delivery device during a first time period;

receiving, from the second medicament delivery device, a second wireless signal associated with a second actual motion profile of the second medicament delivery device, the second actual motion profile including any of a position, a velocity, an acceleration, or an orientation of the second medicament delivery device during a second time period;

producing a first notification indicating that a change in the position of the first medicament delivery device during the first time period is below a threshold associated with the on-person target motion profile; and

suppressing a second notification indicating that a change in the position of the second medicament delivery device during the second time period is below the threshold associated with the on-person target motion profile.

12. The computer-implemented method of claim 11, further comprising:

receiving, from the first medicament delivery device, a third wireless signal to maintain the first communications link, the third wireless signal being periodic;

determining, based on the third wireless signal, a relative position between the mobile computing device and the first medicament delivery device; and

producing a third notification when the relative position exceeds a relative position threshold.

13. The computer-implemented method of claim 12, wherein the producing the third notification includes producing the third notification when the third wireless signal is not received within a third time period.

14. The computer-implemented method of claim 11, wherein the first medicament delivery device is any one of an auto-injector, a pen injector, a medication pump, a prefilled syringe, a nasal delivery device or an inhaler.

15. The computer-implemented method of claim 11, further comprising:

receiving, from the first medicament delivery device, a third wireless signal associated with a temperature profile of the first medicament delivery device; and

producing a third notification when the temperature profile is outside of a predetermined temperature range.

16. A computer-implemented method, comprising:

establishing a communications link, via a short-range wireless protocol, between a mobile computing device and a medicament delivery device;

receiving, in response to an input prompt, a user input selecting a target motion profile of the medicament delivery device;

receiving, from the medicament delivery device, a first wireless signal associated with an actual motion profile of the medicament delivery device;

receiving, from the medicament delivery device, a second wireless signal associated with a temperature profile of the medicament delivery device;

analyzing the actual motion profile to determine if a magnitude of the actual motion profile is outside of a threshold associated with the target motion profile; and

producing a notification when the magnitude of the actual motion profile is outside of the threshold, the notification based on both a motion difference between the actual motion profile and the target motion profile and a temperature difference between the temperature profile and a predetermined temperature range.

17. A computer-implemented method, comprising:

establishing a communications link, via a short-range wireless protocol, between a mobile computing device and a medicament delivery device;

receiving, in response to an input prompt, a user input selecting a target motion profile of the medicament delivery device;

receiving, from the medicament delivery device, a first wireless signal associated with an actual motion profile of the medicament delivery device;

analyzing the actual motion profile to determine if a magnitude of the actual motion profile is outside of a threshold associated with the target motion profile; and

producing by a first application that is executed by a processor of the mobile computing device a first notification when the magnitude of the actual motion profile is outside of the threshold;

receiving, from the medicament delivery device, a second wireless signal associated with a temperature profile of the medicament delivery device;

receiving, from a second application executed by the processor of the mobile computing device, a temperature information;

determining, within the first application and based on the temperature information received from the second application, a temperature range; and

producing a second notification when the temperature profile is outside of the temperature range.

18. The computer-implemented method of claim 17, wherein the actual motion profile includes any of a position, a velocity, an acceleration, or an orientation of the medicament delivery device during a time period.

19. The computer-implemented method of claim 17, wherein the medicament delivery device is any one of an auto-injector, a pen injector, a medication pump, a prefilled syringe, a nasal delivery device or an inhaler.

20. The computer-implemented method of claim 17, wherein:

the second application is a weather application; and

the temperature information includes a local temperature.