Compositions and methods with efficacy against spores and other organisms

• US 10,334,846 B2
• Filed: 10/18/2017
• Issued: 07/02/2019
• Est. Priority Date: 02/07/2014
• Status: Active Grant

• Current Assignee: GOJO Industries Incorporated
• Original Assignee: GOJO Industries Incorporated
• Inventors: Bingham, James Edmund, Macinga, David R.
• Primary Examiner(s): Vajda, Kristin A
• Application Number:
  US15/786,679
• Publication Number:
  US 20180042226A1
• Time in Patent Office: 622 Days
• Field of Search: 514565
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 37/02 Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
• CPC Class Codes: A01N 37/04 polybasic
• CPC Class Codes: A01N 43/16 with oxygen as the ring hetero atom
• CPC Class Codes: A01N 47/28 Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< isoureas, isothioureas A01N47/42
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A01N 59/00 Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• CPC Class Codes: C11D 3/2003 Alcohols; Phenols
• CPC Class Codes: C11D 3/48 Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
• CPC Class Codes: C11D 7/261 Alcohols; Phenols

Abstract

Compositions and methods for the disinfection of surfaces are provided. The compositions include at least about 40 weight percent of a C_1-6 alcohol, and a primary enhancer selected from protein denaturants. The disinfectant composition is characterized by a pH of less than about 3. Broad spectrum efficacy is achieved, and synergistic activity is exhibited against C. difficile spores.

Claims

1. A composition for the disinfection of surfaces, the composition comprising:

at least 40 wt. % of a C_1-6 alcohol, based upon the total weight of the composition; and

at least one primary enhancer,

wherein the composition has a pH of less than 3.

2. The composition of claim 1, wherein the at least one primary enhancer is selected from the group consisting of amine-containing enhancers, α

-aminoacids, salts of alkali metals, salts of alkaline earth metals, and anionic surfactants.

3. The composition of claim 1, wherein the at least one primary enhancer is selected from the group consisting of ammonium chloride, ammonium iron citrate, calcium chloride, iron perchlorate, lithium perchlorate, lithium acetate, magnesium chloride, sodium chlorate, sodium chloride, sodium chlorite, 2-amino-2-hydroxy methyl-propane-1,3-diol hydrochloride, and combinations thereof.

4. The composition of claim 3, wherein the at least one primary enhancer is ammonium chloride.

5. The composition of claim 1, wherein the composition exhibits an enhanced efficacy against C. difficile spores, when compared to the efficacy of the alcohol or primary enhancer alone.

6. The composition of claim 1, further comprising at least one secondary enhancer.

7. The composition of claim 6, wherein the at least one secondary enhancer is selected from the group consisting of non-ionic surfactants, organic acids, antimicrobial agents, oxidizing agents, sugars, sugar alcohols, monosaccharides, glycerol and combinations thereof.

8. The composition of claim 6, wherein the at least one secondary enhancer is selected from the group consisting of decyl glucoside, polyalkoxylated dimethicones, glycerol, and combinations thereof.

9. The composition of claim 7, wherein the organic acid is selected from the group consisting of citric acid, lauric acid, tannic acid, and combinations thereof.

10. The composition of claim 7, wherein the antimicrobial agent is selected from the group consisting of triclosan, PCMX, chloroxylenol, hexetidine, chlorhexidine salts 2-bromo-2-nitropropane-1, 3-diol, benzalkonium chloride, cetylpyridinium chloride, alkylbenzyldimethylammonium chlorides, iodine, phenol, bisphenol, diphenyl ether, phenol derivatives, povidone-iodine, parabens, hydantoins and derivatives thereof, phenoxyethanol, cis isomer of 1-(3-chloroallyl)-3,5,6-triaza-1-azoniaadamantane chloride, diazolidinyl urea, benzethonium chloride, methylbenzethonium chloride, glyceryl laurate, transition metal compounds, hydrogen peroxide, chlorine dioxide, anilides, bisguanidines, tropolone, C_6-10-alkane diols, and combinations thereof.

16. The composition of claim 1, wherein the composition comprises from 0.1 to 20 wt. % of the at least one primary enhancer, based upon the total weight of the composition.

17. The composition of claim 1, wherein the composition has a pH of less than 2.75.

18. The composition of claim 1, wherein the composition has a pH of less than 2.

11. A composition for the inactivation of C. difficile spores on surfaces, the composition comprising:

at least 40 wt. % of a C_1-6 alcohol, based upon the total weight of the composition; and

at least one primary enhancer selected from the group consisting of amine-containing enhancers, α

-aminoacids, salts of alkali metals, salts of alkaline earth metals, and anionic surfactants,

wherein the composition has a pH of less than 3.

12. The composition of claim 11, wherein the at least one primary enhancer is selected from the group consisting of ammonium chloride, ammonium iron citrate, calcium chloride, iron perchlorate, lithium perchlorate, lithium acetate, magnesium chloride, sodium chlorate, sodium chloride, sodium chlorite, 2-amino-2-hydroxy methyl-propane-1,3-diol hydrochloride, and combinations thereof.

13. The composition of claim 12, wherein the at least one primary enhancer is ammonium chloride.

14. The composition of claim 11, further comprising at least one secondary enhancer selected from the group consisting of non-ionic surfactants, organic acids, antimicrobial agents, oxidizing agents, sugars, sugar alcohols, monosaccharides, glycerol and combinations thereof.

19. The composition of claim 11, wherein the composition has a pH of less than 2.75.

20. The composition of claim 11, wherein the composition has a pH of less than 2.

15. A composition for the disinfection of surfaces, the composition comprising:

at least 70 wt. % of a C_1-6 alcohol, based upon the total weight of the composition; and

at least one primary enhancer selected from the group consisting of amine-containing enhancers, α

-aminoacids, salts of alkali metals, salts of alkaline earth metals, and anionic surfactants,

wherein the composition has pH of less than 3.