Body-worn system for measuring continuous non-invasive blood pressure (cNIBP)

• US 10,335,044 B2
• Filed: 06/05/2017
• Issued: 07/02/2019
• Est. Priority Date: 06/12/2007
• Status: Active Grant

• Current Assignee: Sotera Wireless Incorporated
• Original Assignee: Sotera Wireless Incorporated
• Inventors: Banet, Matthew, Dhillon, Marshal, McCombie, Devin
• Primary Examiner(s): Weare, Meredith
• Application Number:
  US15/614,349
• Publication Number:
  US 20180055389A1
• Time in Patent Office: 757 Days
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/02133 by using induced vibration of the blood vessel
• CPC Class Codes: A61B 5/0225 the pressure being controlled by electric signals, e.g. derived from Korotkoff sounds
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/1118 Determining activity level
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/6824 Arm or wrist
• CPC Class Codes: A61B 5/721 using a separate sensor to detect motion or using motion information derived from signals other than the physiological signal to be measured
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence

Abstract

The present invention provides a technique for continuous measurement of blood pressure based on pulse transit time and which does not require any external calibration. This technique, referred to herein as the ‘Composite Method’, is carried out with a body-worn monitor that measures blood pressure and other vital signs, and wirelessly transmits them to a remote monitor. A network of body-worn sensors, typically placed on the patient'"'"'s right arm and chest, connect to the body-worn monitor and measure time-dependent ECG, PPG, accelerometer, and pressure waveforms. The disposable sensors can include a cuff that features an inflatable bladder coupled to a pressure sensor, three or more electrical sensors (e.g. electrodes), three or more accelerometers, a temperature sensor, and an optical sensor (e.g., a light source and photodiode) attached to the patient'"'"'s thumb.

Claims

1. A system for measuring a vital sign value from a patient, comprising:

(a) a first sensor configured to generate a first time-dependent signal indicative of one or more contractile properties of the patient'"'"'s heart;

(b) a second sensor configured to generate a second time-dependent signal indicative of one or more contractile properties of the patient'"'"'s heart, the second sensor comprising a radiation source configured to irradiate a portion of the patient, and a detector configured to detect radiation emitted from the radiation source after it passes through the portion of the patient, the detector comprising at least two pixel elements, each configured to generate a unique pixel element signal;

(c) a motion sensor configured to generate a motion signal indicative of movement of a region of the patient that the motion sensor is attached to; and

,

(d) a processing component configured to be worn on the patient'"'"'s body, the processing component programmed to;

(i) collectively analyze the pixel element signals generated by each of the at least two pixel elements and the motion signal;

(ii) based on the collective analysis of the motion signal and the pixel element signals, select a pixel element signal from one of the at least two pixel elements characterized as having the lowest degree of motion corruption; and

(iii) analyze the pixel element signal selected in (ii) to determine the vital sign value.

2. The system of claim 1, wherein the detector comprises at least a 3×

3 array of pixels.

3. The system of claim 2, wherein each pixel in the array of pixels comprises a photodetector.

4. The system of claim 1, wherein the motion sensor is an accelerometer.

5. The system of claim 4, wherein the accelerometer is configured to generate a digital motion signal corresponding to each of the x, y, and z-axes.

6. The system of claim 1, wherein the processing component is programmed to analyze the motion signal and the pixel element signals to determine the pixel element signal that has the lowest correlation to the motion signal, wherein the pixel element having the lowest degree of motion corruption is identified by the pixel element signal having the lowest correlation to the motion signal as determined by a cross-correlation calculated between the motion signal and the pixel element signals.

7. The system of claim 1, wherein the processing component is programmed to analyze the motion signal to determine a measurement period when patient movement is relatively low, and then measure a signal from each pixel element.

8. The system of claim 1, wherein the first sensor comprises an ECG circuit and at least two electrodes.

9. The system of claim 8, wherein the first time-dependent signal comprises an ECG signal.

10. The system of claim 9, wherein the processing component is programmed to determine a QRS complex comprised by the ECG signal.

11. The system of claim 10, wherein the processing component is programmed to determine a time difference between the QRS complex and the onset point.

12. The system of claim 11, wherein the processing component is programmed to calculate a blood pressure value from the time difference.

13. The system of claim 8, wherein the first sensor is configured to be worn on the patient'"'"'s chest.

14. The system of claim 1, wherein the signal selected from at least one of the pixel elements comprises a PPG signal.

15. The system of claim 14, wherein the processing component is programmed to determine an onset point in a portion comprised by the PPG signal.

16. The system of claim 1, further comprising a transceiver configured to be worn on the patient'"'"'s arm that comprises the processing component.

17. The system of claim 16, wherein the transceiver comprises the motion sensor.