Method for increasing the specific production rate of eukaryotic cells

  • US 10,336,983 B2
  • Filed: 02/09/2017
  • Issued: 07/02/2019
  • Est. Priority Date: 08/11/2014
  • Status: Active Grant
First Claim
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1. A method for increasing specific productivity (qP) of a recombinant Chinese Hamster Ovary (CHO) cell that produces an exogenous polypeptide, the method comprising culturing the CHO cell in a culture medium comprising meta-tyrosine at a concentration of from 0.2 mM to 0.7 mM, whereby the specific productivity (qP) is increased by at least 5% compared to an identical culturing process without supplementation of meta-tyrosine in the culture medium.

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