Systems and methods for increasing convective clearance of undesired particles in a microfluidic device
First Claim
1. A microfluidic device comprising:
- a first layer defining an infusate channel having an inlet and an outlet, the infusate channel having a first pressure profile;
a second layer defining a blood channel complementary to and in fluidic communication with the infusate channel, the blood channel having a second pressure profile;
an interchannel flow barrier separating the infusate channel and the blood channel allowing a portion of fluid flowing into the inlet of the infusate channel to flow through the interchannel flow barrier and into the blood channel;
a third layer defining a filtrate channel complementary to and in fluidic communication with the blood channel, the filtrate channel having a third pressure profile;
one or more pressure sensors configured to measure fluid pressure characteristics in at least one of the filtrate channel and the blood channel; and
a pressure control feature comprising a filtrate fluid circuit including a processor that implements flow control logic responsive to at least one measurement received from the one or more pressure sensors, the processor coupled with a recirculation pump positioned between an inlet of the filtrate channel and an outlet of the filtrate channel, wherein the flow control logic implemented by the processor causes the recirculation pump to control a filtrate flow rate through the filtrate channel and to control a difference between the second pressure profile and the third pressure profile along a length of the filtrate and blood channels such that the pressure difference between the blood channel and the filtrate channel varies by less than 50% of the pressure difference between the blood channel and filtrate channel at an upstream end of the blood channel and the filtrate channel.
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Accused Products
Abstract
A microfluidic device for increasing convective clearance of particles from a fluid is provided. In some implementations, described herein the microfluidic device includes multiple layers that each define infusate, blood, and filtrate channels. Each of the channels have a pressure profile. The device can also include one or more pressure control features. The pressure control feature controls a difference between the pressure profiles along a length of the device. For example, the pressure control feature can control the difference between the pressure profile of the filtrate channel and the pressure profile of the blood channel. In some implementations, the pressure control feature controls the pressure difference between two channels such that the difference varies along the length of the channels by less than 50% of the pressure difference between the channels at the channels'"'"' inlets.
33 Citations
25 Claims
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1. A microfluidic device comprising:
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a first layer defining an infusate channel having an inlet and an outlet, the infusate channel having a first pressure profile; a second layer defining a blood channel complementary to and in fluidic communication with the infusate channel, the blood channel having a second pressure profile; an interchannel flow barrier separating the infusate channel and the blood channel allowing a portion of fluid flowing into the inlet of the infusate channel to flow through the interchannel flow barrier and into the blood channel; a third layer defining a filtrate channel complementary to and in fluidic communication with the blood channel, the filtrate channel having a third pressure profile; one or more pressure sensors configured to measure fluid pressure characteristics in at least one of the filtrate channel and the blood channel; and a pressure control feature comprising a filtrate fluid circuit including a processor that implements flow control logic responsive to at least one measurement received from the one or more pressure sensors, the processor coupled with a recirculation pump positioned between an inlet of the filtrate channel and an outlet of the filtrate channel, wherein the flow control logic implemented by the processor causes the recirculation pump to control a filtrate flow rate through the filtrate channel and to control a difference between the second pressure profile and the third pressure profile along a length of the filtrate and blood channels such that the pressure difference between the blood channel and the filtrate channel varies by less than 50% of the pressure difference between the blood channel and filtrate channel at an upstream end of the blood channel and the filtrate channel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A microfluidic device comprising:
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a first layer defining an infusate channel having an inlet and an outlet, the infusate channel having a first pressure profile; a second layer defining a blood channel complementary to and in fluidic communication with the infusate channel, the blood channel having a second pressure profile; an interchannel flow barrier separating the infusate channel and the blood channel allowing a portion of fluid flowing into the inlet of the infusate channel to flow through the interchannel flow barrier and into the blood channel; a third layer defining a filtrate channel complementary to and in fluidic communication with the blood channel, the filtrate channel having a third pressure profile; one or more pressure sensors configured to measure fluid pressure characteristics in at least one of the filtrate channel and the blood channel; and a pressure control feature comprising a filtrate fluid circuit including a processor that implements flow control logic responsive to at least one measurement received from the one or more pressure sensors, the processor coupled with a recirculation pump positioned between an inlet of the filtrate channel and an outlet of the filtrate channel, wherein the flow control logic implemented by the processor causes the recirculation pump to control a filtrate flow rate through the filtrate channel and to control a pressure difference between at least two of the first pressure profile, the second pressure profile, and the third pressure profile along a length of the device such that the pressure difference varies by less than 50% of the pressure difference between the at least two of the first pressure profile, the second pressure profile, and the third pressure profile at an upstream end of the infusate, blood, and filtrate channels.
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Specification