Method and system for microbiome-derived diagnostics and therapeutics for neurological health issues
First Claim
1. A method for diagnosing and treating an autism spectrum disorder in a subject, the method comprising:
- at a sample handling network, processing nucleic acid content of a sample from the subject, thereby generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset associated with the sample;
identifying an association between the sample and at least one of a taxonomic feature from the microbiome composition dataset and a functional feature from the microbiome functional diversity dataset, upon processing the sample from the subject;
based upon the association, diagnosing the subject with the autism spectrum disorder; and
providing a therapy to the subject associated with the autism spectrum disorder for facilitating improvement of a health state of the subject.
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Accused Products
Abstract
A method for at least one of characterizing, diagnosing and treating a neurological health issue in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the neurological health issue based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the neurological health issue; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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Citations
20 Claims
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1. A method for diagnosing and treating an autism spectrum disorder in a subject, the method comprising:
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at a sample handling network, processing nucleic acid content of a sample from the subject, thereby generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset associated with the sample; identifying an association between the sample and at least one of a taxonomic feature from the microbiome composition dataset and a functional feature from the microbiome functional diversity dataset, upon processing the sample from the subject; based upon the association, diagnosing the subject with the autism spectrum disorder; and providing a therapy to the subject associated with the autism spectrum disorder for facilitating improvement of a health state of the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for characterizing an autism spectrum disorder in at least a subject, the method comprising:
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at a sample handling network, receiving an aggregate set of samples from a population of subjects; generating a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects upon processing nucleic acid content of each of the aggregate set of samples; receiving a supplementary dataset, associated with at least a subset of the population of subjects, wherein the supplementary dataset is informative of characteristics associated with the autism spectrum disorder; transforming the supplementary dataset and features extracted from the microbiome composition dataset and the microbiome functional diversity dataset into a characterization model of the autism spectrum disorder; based upon the characterization model, generating a therapy model configured to improve a state of the autism spectrum disorder; and providing a therapy to the subject associated with the autism spectrum disorder, based on the therapy model. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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Specification