Anti-inflammatory cannula

• US 10,363,342 B2
• Filed: 01/30/2017
• Issued: 07/30/2019
• Est. Priority Date: 02/04/2016
• Status: Active Grant

• Current Assignee: Insulet Corporation
• Original Assignee: Insulet Corporation
• Inventors: Dillon, Bryan, Choate, Bryan
• Primary Examiner(s): Price, Nathan R
• Assistant Examiner(s): Ahmed, Tasnim Mehjabin
• Application Number:
  US15/419,369
• Publication Number:
  US 20170224877A1
• Time in Patent Office: 911 Days
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/202 with halogen atoms, e.g. triclosan, povidone-iodine
• CPC Class Codes: A61L 2300/208 Quaternary ammonium compounds
• CPC Class Codes: A61L 2300/222 Steroids, e.g. corticosteroids
• CPC Class Codes: A61L 2300/232 Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
• CPC Class Codes: A61L 2300/236 Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2300/43 Hormones, e.g. dexamethasone
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 27/28 Materials for coating prostheses
• CPC Class Codes: A61L 27/306 Other specific inorganic materials not covered by A61L27/303 - A61L27/32
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/106 Inorganic materials other than carbon
• CPC Class Codes: A61L 29/14 : Materials characterised by their function or physical properties , e.g. lubricating compositions
• CPC Class Codes: A61L 29/16 : Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 33/0005 : Use of materials characterised by their function or physical properties
• CPC Class Codes: A61L 33/0011 : Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
• CPC Class Codes: A61L 33/06 : Use of macromolecular materials grafting of a monomer onto the substrate A61L33/0088
• CPC Class Codes: A61L 33/068 : obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L33/062 takes precedence
• CPC Class Codes: A61M 2005/1586 : Holding accessories for holding infusion needles on the body holding devices for catheters A61M25/02
• CPC Class Codes: A61M 5/14248 : of the skin patch type
• CPC Class Codes: A61M 5/158 : Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
• CPC Class Codes: C08L 27/12 : containing fluorine atoms
• CPC Class Codes: C08L 27/18 : Homopolymers or copolymers or tetrafluoroethene
• CPC Class Codes: C08L 33/08 : Homopolymers or copolymers of acrylic acid esters
• CPC Class Codes: C08L 39/06 : Homopolymers or copolymers of N-vinyl-pyrrolidones
• CPC Class Codes: C08L 5/08 : Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
• CPC Class Codes: C08L 5/10 : Heparin; Derivatives thereof
• CPC Class Codes: C08L 67/04 : Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: C08L 71/02 : Polyalkylene oxides
• CPC Class Codes: C08L 75/04 : Polyurethanes
• CPC Class Codes: C08L 83/04 : Polysiloxanes

Abstract

Various embodiments of the present invention include a cannula coated or compounded with a material to extend the wear time for a patient by reducing inflammation and therefore increasing the time that the cannula may remain inserted, thereby increasing the effectiveness of the drug delivered using the cannula. The material may include a hydrophilic material, an anti-microbial material, an anti-inflammatory material, anti-thrombogenic material, or a combination of any of these materials.

Claims

1. A wearable fluid delivery device, comprising:

a chamber containing a fluid to be delivered into a body of a patient; and

a cannula in fluid connection with the chamber, the cannula comprising an exterior surface, an inner surface, a lumen and a distal end extending into the patient, wherein the cannula comprises a first material and a second material mixed with the first material, the second material disposed in discrete regions of the cannula, the second material comprising at least one of a hydrophilic material, an anti-microbial material, an anti-inflammatory material, and an anti-thombogenic material, wherein a first coating at least partially covers the exterior surface of the cannula, the first coating comprising an anti-inflammatory agent, wherein a second coating at least partially covers the interior surface of the cannula, the second coating comprising at least one of the hydrophilic material, the anti-microbial material, the anti-inflammatory material, and the anti-thombogenic material,

wherein the second coating covers less than an entire length of the inner surface of the cannula,

wherein the first coating covers less than an entire length of the exterior surface of the cannula,

wherein the second coating coats less than an entire perimeter of the inner surface of the cannula,

wherein the first coating coats less than an entire perimeter of the exterior surface of the cannula,

wherein a third coating at least partially covers the exterior surface of the cannula, the third coating comprising at least one of the hydrophilic material, the anti-microbial material, the anti-inflammatory material, and the anti-thombogenic material, wherein the first and second coatings comprise different materials,

wherein the third coating is disposed in a concentration gradient throughout the first coating.

2. The wearable fluid delivery device of claim 1, wherein the first material of the cannula comprises a polymeric material.

3. The wearable fluid delivery device of claim 1, the first coating having a thickness of up to 500 microns.

4. The wearable fluid delivery device of claim 1, the first coating having a thickness of up to 50 microns.

5. The wearable fluid delivery device of claim 1, wherein the first coating comprises a material selected from the group consisting of heparin, silver and its alloys, rifampicin, sparfloxacin, triclosan, benalkonium chloride, tridodecylmethylammonium chloride, cefazolin, chitosan, dexamethasone sodium phosphate, polyvinylpyrolidone (PVP), polyurethanes, fluoropolymers, silicone, polyacrylic acid (PAA), polyethylene oxide (PEO), polysaccharides, polyether block amides, and fluorine-acryl-styrene-urethane-silicone (FASUS).

6. The wearable fluid delivery device of claim 5, wherein the first material of the cannula comprises polyurethane.

7. The wearable fluid delivery device of claim 5, wherein the first coating comprises a polyether block amide.

8. The wearable fluid delivery device of claim 1, wherein said second coating comprises an anti-thrombogenic material.

9. The wearable fluid delivery device of claim 8, wherein said second coating comprises a fluorinated ethylene propylene.

10. The wearable fluid delivery device of claim 1, wherein the cannula comprises a single unitary body.

11. The wearable fluid delivery device of claim 1, wherein a fourth coating at least partially covers the inner surface of the cannula, the fourth coating comprising at least one of a hydrophilic material, an anti-microbial material, an anti-inflammatory material, and an anti-thombogenic material, the second and fourth coatings comprising different materials.

12. The wearable fluid delivery device of claim 11, wherein the second and fourth coatings are mixed homogeneously.

13. The wearable fluid delivery device of claim 11, wherein the fourth coating is disposed in discrete regions of the second coating.

14. The wearable fluid delivery device of claim 11, wherein the second and fourth coatings overlap.

15. The wearable fluid delivery device of claim 11, wherein the second and fourth coatings are non-overlapping.

16. The wearable fluid delivery device of claim 11, wherein the fourth coating is disposed in a concentration gradient throughout the second coating.

17. The wearable fluid delivery device of claim 1, wherein the cannula comprises a third material mixed with the first material, the third material disposed in discrete regions of the cannula, the third material comprising at least one of the hydrophilic material, the anti-microbial material, the anti-inflammatory material, and the anti-thombogenic material, wherein the first, second, and third materials of the cannula each comprise different materials.