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Peptide for inducing regeneration of tissue and use thereof

  • US 10,364,276 B2
  • Filed: 04/03/2012
  • Issued: 07/30/2019
  • Est. Priority Date: 04/26/2011
  • Status: Active Grant
First Claim
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1. A method of stimulating migration of a cell, mobilizing a cell from bone marrow to peripheral blood, and/or regenerating a tissue, in the body of a subject, wherein said method comprises administering to the subject an effective amount of a substance of any one of (a) to (c) below;

  • (a) a peptide consisting of a portion of an HMGB1 protein of SEQ ID NO;

    1 and having cell migration-stimulating activity;

    (b) a cell secreting said peptide of (a); and

    (c) a vector into which a DNA encoding said peptide of (a) is inserted, wherein said peptide has an activity of stimulating migration of a cell and said peptide consists of all or part of the amino acid sequence of positions 1 to 195 of SEQ ID NO;

    1.

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